Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
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Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. / Louveau, Antoine; Plog, Benjamin A.; Antila, Salli; Alitalo, Kari; Nedergaard, Maiken; Kipnis, Jonathan.
In: The Journal of Clinical Investigation, Vol. 127, No. 9, 01.09.2017, p. 3210-3219.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
AU - Louveau, Antoine
AU - Plog, Benjamin A.
AU - Antila, Salli
AU - Alitalo, Kari
AU - Nedergaard, Maiken
AU - Kipnis, Jonathan
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have generated a lot of excitement, along with some degree of skepticism. Here, we summarize the state of the field and point out the gaps of knowledge that should be filled through further research. We discuss the glymphatic system as a system that allows CNS perfusion by the cerebrospinal fluid (CSF) and interstitial fluid (ISF). We also describe the recently characterized meningeal lymphatic vessels and their role in drainage of the brain ISF, CSF, CNS-derived molecules, and immune cells from the CNS and meninges to the peripheral (CNS-draining) lymph nodes. We speculate on the relationship between the two systems and their malfunction that may underlie some neurological diseases. Although much remains to be investigated, these new discoveries have changed our understanding of mechanisms underlying CNS immune privilege and CNS drainage. Future studies should explore the communications between the glymphatic system and meningeal lymphatics in CNS disorders and develop new therapeutic modalities targeting these systems.
AB - Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have generated a lot of excitement, along with some degree of skepticism. Here, we summarize the state of the field and point out the gaps of knowledge that should be filled through further research. We discuss the glymphatic system as a system that allows CNS perfusion by the cerebrospinal fluid (CSF) and interstitial fluid (ISF). We also describe the recently characterized meningeal lymphatic vessels and their role in drainage of the brain ISF, CSF, CNS-derived molecules, and immune cells from the CNS and meninges to the peripheral (CNS-draining) lymph nodes. We speculate on the relationship between the two systems and their malfunction that may underlie some neurological diseases. Although much remains to be investigated, these new discoveries have changed our understanding of mechanisms underlying CNS immune privilege and CNS drainage. Future studies should explore the communications between the glymphatic system and meningeal lymphatics in CNS disorders and develop new therapeutic modalities targeting these systems.
KW - Alzheimer Disease
KW - Amyloid beta-Peptides
KW - Animals
KW - Brain
KW - Central Nervous System
KW - Central Nervous System Diseases
KW - Dura Mater
KW - Extracellular Fluid
KW - Humans
KW - Immune System
KW - Lymph Nodes
KW - Lymphatic System
KW - Lymphatic Vessels
KW - Meninges
KW - Neuroglia
KW - Journal Article
KW - Review
U2 - 10.1172/JCI90603
DO - 10.1172/JCI90603
M3 - Review
C2 - 28862640
VL - 127
SP - 3210
EP - 3219
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 9
ER -
ID: 185945250