Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output. / Dietz, Andrea Grostøl; Weikop, Pia; Hauglund, Natalie; Andersen, Mie; Petersen, Nicolas Caesar; Rose, Laura; Hirase, Hajime; Nedergaard, Maiken.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, No. 40, e2305071120, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dietz, AG, Weikop, P, Hauglund, N, Andersen, M, Petersen, NC, Rose, L, Hirase, H & Nedergaard, M 2023, 'Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 40, e2305071120. https://doi.org/10.1073/pnas.2305071120

APA

Dietz, A. G., Weikop, P., Hauglund, N., Andersen, M., Petersen, N. C., Rose, L., Hirase, H., & Nedergaard, M. (2023). Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output. Proceedings of the National Academy of Sciences of the United States of America, 120(40), [e2305071120]. https://doi.org/10.1073/pnas.2305071120

Vancouver

Dietz AG, Weikop P, Hauglund N, Andersen M, Petersen NC, Rose L et al. Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output. Proceedings of the National Academy of Sciences of the United States of America. 2023;120(40). e2305071120. https://doi.org/10.1073/pnas.2305071120

Author

Dietz, Andrea Grostøl ; Weikop, Pia ; Hauglund, Natalie ; Andersen, Mie ; Petersen, Nicolas Caesar ; Rose, Laura ; Hirase, Hajime ; Nedergaard, Maiken. / Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output. In: Proceedings of the National Academy of Sciences of the United States of America. 2023 ; Vol. 120, No. 40.

Bibtex

@article{975169da8029460982580c196b5c6ed8,
title = "Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output",
abstract = "Extracellular potassium concentration ([K+]e) is known to increase as a function of arousal. [K+]e is also a potent modulator of transmitter release. Yet, it is not known whether [K+]e is involved in the neuromodulator release associated with behavioral transitions. We here show that manipulating [K+]e controls the local release of monoaminergic neuromodulators, including norepinephrine (NE), serotonin, and dopamine. Imposing a [K+]e increase is adequate to boost local NE levels, and conversely, lowering [K+]e can attenuate local NE. Electroencephalography analysis and behavioral assays revealed that manipulation of cortical [K+]e was sufficient to alter the sleep-wake cycle and behavior of mice. These observations point to the concept that NE levels in the cortex are not solely determined by subcortical release, but that local [K+]e dynamics have a strong impact on cortical NE. Thus, cortical [K+]e is an underappreciated regulator of behavioral transitions. ",
keywords = "cortical state change, ions, neuromodulators",
author = "Dietz, {Andrea Grost{\o}l} and Pia Weikop and Natalie Hauglund and Mie Andersen and Petersen, {Nicolas Caesar} and Laura Rose and Hajime Hirase and Maiken Nedergaard",
note = "Publisher Copyright: {\textcopyright} 2023 the Author(s).",
year = "2023",
doi = "10.1073/pnas.2305071120",
language = "English",
volume = "120",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "40",

}

RIS

TY - JOUR

T1 - Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output

AU - Dietz, Andrea Grostøl

AU - Weikop, Pia

AU - Hauglund, Natalie

AU - Andersen, Mie

AU - Petersen, Nicolas Caesar

AU - Rose, Laura

AU - Hirase, Hajime

AU - Nedergaard, Maiken

N1 - Publisher Copyright: © 2023 the Author(s).

PY - 2023

Y1 - 2023

N2 - Extracellular potassium concentration ([K+]e) is known to increase as a function of arousal. [K+]e is also a potent modulator of transmitter release. Yet, it is not known whether [K+]e is involved in the neuromodulator release associated with behavioral transitions. We here show that manipulating [K+]e controls the local release of monoaminergic neuromodulators, including norepinephrine (NE), serotonin, and dopamine. Imposing a [K+]e increase is adequate to boost local NE levels, and conversely, lowering [K+]e can attenuate local NE. Electroencephalography analysis and behavioral assays revealed that manipulation of cortical [K+]e was sufficient to alter the sleep-wake cycle and behavior of mice. These observations point to the concept that NE levels in the cortex are not solely determined by subcortical release, but that local [K+]e dynamics have a strong impact on cortical NE. Thus, cortical [K+]e is an underappreciated regulator of behavioral transitions.

AB - Extracellular potassium concentration ([K+]e) is known to increase as a function of arousal. [K+]e is also a potent modulator of transmitter release. Yet, it is not known whether [K+]e is involved in the neuromodulator release associated with behavioral transitions. We here show that manipulating [K+]e controls the local release of monoaminergic neuromodulators, including norepinephrine (NE), serotonin, and dopamine. Imposing a [K+]e increase is adequate to boost local NE levels, and conversely, lowering [K+]e can attenuate local NE. Electroencephalography analysis and behavioral assays revealed that manipulation of cortical [K+]e was sufficient to alter the sleep-wake cycle and behavior of mice. These observations point to the concept that NE levels in the cortex are not solely determined by subcortical release, but that local [K+]e dynamics have a strong impact on cortical NE. Thus, cortical [K+]e is an underappreciated regulator of behavioral transitions.

KW - cortical state change

KW - ions

KW - neuromodulators

U2 - 10.1073/pnas.2305071120

DO - 10.1073/pnas.2305071120

M3 - Journal article

C2 - 37774097

AN - SCOPUS:85173766275

VL - 120

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 40

M1 - e2305071120

ER -

ID: 371284941