Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema. / Du, Ting; Mestre, Humberto; Kress, Benjamin T; Liu, Guojun; Sweeney, Amanda M; Samson, Andrew J; Rasmussen, Martin Kaag; Mortensen, Kristian Nygaard; Bork, Peter A R; Peng, Weiguo; Olveda, Genaro E; Bashford, Logan; Toro, Edna R; Tithof, Jeffrey; Kelley, Douglas H; Thomas, John H; Hjorth, Poul G; Martens, Erik A; Mehta, Rupal I; Hirase, Hajime; Mori, Yuki; Nedergaard, Maiken.

In: Brain, Vol. 145, No. 2, 2022, p. 787–797.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Du, T, Mestre, H, Kress, BT, Liu, G, Sweeney, AM, Samson, AJ, Rasmussen, MK, Mortensen, KN, Bork, PAR, Peng, W, Olveda, GE, Bashford, L, Toro, ER, Tithof, J, Kelley, DH, Thomas, JH, Hjorth, PG, Martens, EA, Mehta, RI, Hirase, H, Mori, Y & Nedergaard, M 2022, 'Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema', Brain, vol. 145, no. 2, pp. 787–797. https://doi.org/10.1093/brain/awab293

APA

Du, T., Mestre, H., Kress, B. T., Liu, G., Sweeney, A. M., Samson, A. J., Rasmussen, M. K., Mortensen, K. N., Bork, P. A. R., Peng, W., Olveda, G. E., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., ... Nedergaard, M. (2022). Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema. Brain, 145(2), 787–797. https://doi.org/10.1093/brain/awab293

Vancouver

Du T, Mestre H, Kress BT, Liu G, Sweeney AM, Samson AJ et al. Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema. Brain. 2022;145(2):787–797. https://doi.org/10.1093/brain/awab293

Author

Du, Ting ; Mestre, Humberto ; Kress, Benjamin T ; Liu, Guojun ; Sweeney, Amanda M ; Samson, Andrew J ; Rasmussen, Martin Kaag ; Mortensen, Kristian Nygaard ; Bork, Peter A R ; Peng, Weiguo ; Olveda, Genaro E ; Bashford, Logan ; Toro, Edna R ; Tithof, Jeffrey ; Kelley, Douglas H ; Thomas, John H ; Hjorth, Poul G ; Martens, Erik A ; Mehta, Rupal I ; Hirase, Hajime ; Mori, Yuki ; Nedergaard, Maiken. / Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema. In: Brain. 2022 ; Vol. 145, No. 2. pp. 787–797.

Bibtex

@article{cd73ffa547ee4b93a4f2e8d40a21cb2c,
title = "Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema",
abstract = "Cerebral edema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that edema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of cerebrospinal fluid (CSF). Edema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of edema. Edema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex vivo tissue swelling was predicted by an osmotic model suggesting that anoxic brain tissue possesses a high intrinsic osmotic potential. This osmotic process was temperature-dependent, proposing an additional mechanism for the beneficial effect of therapeutic hypothermia. These observations show that CSF is a primary source of edema fluid in anoxic brain. This novel insight offers a mechanistic basis for the future development of alternative strategies to prevent cerebral edema formation after cardiac arrest.",
author = "Ting Du and Humberto Mestre and Kress, {Benjamin T} and Guojun Liu and Sweeney, {Amanda M} and Samson, {Andrew J} and Rasmussen, {Martin Kaag} and Mortensen, {Kristian Nygaard} and Bork, {Peter A R} and Weiguo Peng and Olveda, {Genaro E} and Logan Bashford and Toro, {Edna R} and Jeffrey Tithof and Kelley, {Douglas H} and Thomas, {John H} and Hjorth, {Poul G} and Martens, {Erik A} and Mehta, {Rupal I} and Hajime Hirase and Yuki Mori and Maiken Nedergaard",
note = "{\textcopyright} The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2022",
doi = "10.1093/brain/awab293",
language = "English",
volume = "145",
pages = "787–797",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

AU - Du, Ting

AU - Mestre, Humberto

AU - Kress, Benjamin T

AU - Liu, Guojun

AU - Sweeney, Amanda M

AU - Samson, Andrew J

AU - Rasmussen, Martin Kaag

AU - Mortensen, Kristian Nygaard

AU - Bork, Peter A R

AU - Peng, Weiguo

AU - Olveda, Genaro E

AU - Bashford, Logan

AU - Toro, Edna R

AU - Tithof, Jeffrey

AU - Kelley, Douglas H

AU - Thomas, John H

AU - Hjorth, Poul G

AU - Martens, Erik A

AU - Mehta, Rupal I

AU - Hirase, Hajime

AU - Mori, Yuki

AU - Nedergaard, Maiken

N1 - © The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2022

Y1 - 2022

N2 - Cerebral edema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that edema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of cerebrospinal fluid (CSF). Edema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of edema. Edema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex vivo tissue swelling was predicted by an osmotic model suggesting that anoxic brain tissue possesses a high intrinsic osmotic potential. This osmotic process was temperature-dependent, proposing an additional mechanism for the beneficial effect of therapeutic hypothermia. These observations show that CSF is a primary source of edema fluid in anoxic brain. This novel insight offers a mechanistic basis for the future development of alternative strategies to prevent cerebral edema formation after cardiac arrest.

AB - Cerebral edema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that edema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of cerebrospinal fluid (CSF). Edema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of edema. Edema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex vivo tissue swelling was predicted by an osmotic model suggesting that anoxic brain tissue possesses a high intrinsic osmotic potential. This osmotic process was temperature-dependent, proposing an additional mechanism for the beneficial effect of therapeutic hypothermia. These observations show that CSF is a primary source of edema fluid in anoxic brain. This novel insight offers a mechanistic basis for the future development of alternative strategies to prevent cerebral edema formation after cardiac arrest.

U2 - 10.1093/brain/awab293

DO - 10.1093/brain/awab293

M3 - Journal article

C2 - 34581781

VL - 145

SP - 787

EP - 797

JO - Brain

JF - Brain

SN - 0006-8950

IS - 2

ER -

ID: 286847968