Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow
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Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow. / Bork, Peter A.R.; Ladrón-De-Guevara, Antonio; Christensen, Anneline H.; Jensen, Kaare H.; Nedergaard, Maiken; Bohr, Tomas.
In: Journal of the Royal Society Interface, Vol. 20, No. 204, 20230050, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow
AU - Bork, Peter A.R.
AU - Ladrón-De-Guevara, Antonio
AU - Christensen, Anneline H.
AU - Jensen, Kaare H.
AU - Nedergaard, Maiken
AU - Bohr, Tomas
N1 - Publisher Copyright: © 2023 The Author(s).
PY - 2023
Y1 - 2023
N2 - The glymphatic system of cerebrospinal fluid transport through the perivascular spaces of the brain has been implicated in metabolic waste clearance, neurodegenerative diseases and in acute neurological disorders such as stroke and cardiac arrest. In other biological low-pressure fluid pathways such as in veins and the peripheral lymphatic system, valves play an important role in ensuring the flow direction. Though fluid pressure is low in the glymphatic system and directed bulk flow has been measured in pial and penetrating perivascular spaces, no valves have yet been identified. Valves, which asymmetrically favour forward flow to backward flow, would imply that the considerable oscillations in blood and ventricle volumes seen in magnetic resonance imaging could cause directed bulk flow. Here, we propose that astrocyte endfeet may act as such valves using a simple elastic mechanism. We combine a recent fluid mechanical model of viscous flow between elastic plates with recent measurements of in vivo elasticity of the brain to predict order of magnitude flow-characteristics of the valve. The modelled endfeet are effective at allowing forward while preventing backward flow.
AB - The glymphatic system of cerebrospinal fluid transport through the perivascular spaces of the brain has been implicated in metabolic waste clearance, neurodegenerative diseases and in acute neurological disorders such as stroke and cardiac arrest. In other biological low-pressure fluid pathways such as in veins and the peripheral lymphatic system, valves play an important role in ensuring the flow direction. Though fluid pressure is low in the glymphatic system and directed bulk flow has been measured in pial and penetrating perivascular spaces, no valves have yet been identified. Valves, which asymmetrically favour forward flow to backward flow, would imply that the considerable oscillations in blood and ventricle volumes seen in magnetic resonance imaging could cause directed bulk flow. Here, we propose that astrocyte endfeet may act as such valves using a simple elastic mechanism. We combine a recent fluid mechanical model of viscous flow between elastic plates with recent measurements of in vivo elasticity of the brain to predict order of magnitude flow-characteristics of the valve. The modelled endfeet are effective at allowing forward while preventing backward flow.
KW - cerebrospinal fluid
KW - glymphatic system
KW - interstitial fluid
KW - pressure oscillation
KW - pressure valve
U2 - 10.1098/rsif.2023.0050
DO - 10.1098/rsif.2023.0050
M3 - Journal article
C2 - 37434503
AN - SCOPUS:85164436164
VL - 20
JO - Journal of the Royal Society Interface
JF - Journal of the Royal Society Interface
SN - 2042-8898
IS - 204
M1 - 20230050
ER -
ID: 370481405