A mesothelium divides the subarachnoid space into functional compartments

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A mesothelium divides the subarachnoid space into functional compartments. / Møllgård, Kjeld; Beinlich, Felix R. M.; Kusk, Peter; Miyakoshi, Leo M.; Delle, Christine; Plá, Virginia; Hauglund, Natalie L.; Esmail, Tina; Rasmussen, Martin K.; Gomolka, Ryszard S.; Mori, Yuki; Nedergaard, Maiken.

In: Science, Vol. 379, No. 6627, 2023, p. 84-885.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Møllgård, K, Beinlich, FRM, Kusk, P, Miyakoshi, LM, Delle, C, Plá, V, Hauglund, NL, Esmail, T, Rasmussen, MK, Gomolka, RS, Mori, Y & Nedergaard, M 2023, 'A mesothelium divides the subarachnoid space into functional compartments', Science, vol. 379, no. 6627, pp. 84-885. https://doi.org/10.1126/science.adc8810

APA

Møllgård, K., Beinlich, F. R. M., Kusk, P., Miyakoshi, L. M., Delle, C., Plá, V., Hauglund, N. L., Esmail, T., Rasmussen, M. K., Gomolka, R. S., Mori, Y., & Nedergaard, M. (2023). A mesothelium divides the subarachnoid space into functional compartments. Science, 379(6627), 84-885. https://doi.org/10.1126/science.adc8810

Vancouver

Møllgård K, Beinlich FRM, Kusk P, Miyakoshi LM, Delle C, Plá V et al. A mesothelium divides the subarachnoid space into functional compartments. Science. 2023;379(6627):84-885. https://doi.org/10.1126/science.adc8810

Author

Møllgård, Kjeld ; Beinlich, Felix R. M. ; Kusk, Peter ; Miyakoshi, Leo M. ; Delle, Christine ; Plá, Virginia ; Hauglund, Natalie L. ; Esmail, Tina ; Rasmussen, Martin K. ; Gomolka, Ryszard S. ; Mori, Yuki ; Nedergaard, Maiken. / A mesothelium divides the subarachnoid space into functional compartments. In: Science. 2023 ; Vol. 379, No. 6627. pp. 84-885.

Bibtex

@article{959295d5dca34a80932f7af9c69b95a3,
title = "A mesothelium divides the subarachnoid space into functional compartments",
abstract = "The central nervous system is lined by meninges, classically known as dura, arachnoid, and pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the subarachnoid space in the mouse and human brain, designated the subarachnoid lymphatic-like membrane (SLYM). SLYM is morpho- and immunophenotypically similar to the mesothelial membrane lining of peripheral organs and body cavities, and it encases blood vessels and harbors immune cells. Functionally, the close apposition of SLYM with the endothelial lining of the meningeal venous sinus permits direct exchange of small solutes between cerebrospinal fluid and venous blood, thus representing the mouse equivalent of the arachnoid granulations. The functional characterization of SLYM provides fundamental insights into brain immune barriers and fluid transport",
author = "Kjeld M{\o}llg{\aa}rd and Beinlich, {Felix R. M.} and Peter Kusk and Miyakoshi, {Leo M.} and Christine Delle and Virginia Pl{\'a} and Hauglund, {Natalie L.} and Tina Esmail and Rasmussen, {Martin K.} and Gomolka, {Ryszard S.} and Yuki Mori and Maiken Nedergaard",
year = "2023",
doi = "10.1126/science.adc8810",
language = "English",
volume = "379",
pages = "84--885",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6627",

}

RIS

TY - JOUR

T1 - A mesothelium divides the subarachnoid space into functional compartments

AU - Møllgård, Kjeld

AU - Beinlich, Felix R. M.

AU - Kusk, Peter

AU - Miyakoshi, Leo M.

AU - Delle, Christine

AU - Plá, Virginia

AU - Hauglund, Natalie L.

AU - Esmail, Tina

AU - Rasmussen, Martin K.

AU - Gomolka, Ryszard S.

AU - Mori, Yuki

AU - Nedergaard, Maiken

PY - 2023

Y1 - 2023

N2 - The central nervous system is lined by meninges, classically known as dura, arachnoid, and pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the subarachnoid space in the mouse and human brain, designated the subarachnoid lymphatic-like membrane (SLYM). SLYM is morpho- and immunophenotypically similar to the mesothelial membrane lining of peripheral organs and body cavities, and it encases blood vessels and harbors immune cells. Functionally, the close apposition of SLYM with the endothelial lining of the meningeal venous sinus permits direct exchange of small solutes between cerebrospinal fluid and venous blood, thus representing the mouse equivalent of the arachnoid granulations. The functional characterization of SLYM provides fundamental insights into brain immune barriers and fluid transport

AB - The central nervous system is lined by meninges, classically known as dura, arachnoid, and pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the subarachnoid space in the mouse and human brain, designated the subarachnoid lymphatic-like membrane (SLYM). SLYM is morpho- and immunophenotypically similar to the mesothelial membrane lining of peripheral organs and body cavities, and it encases blood vessels and harbors immune cells. Functionally, the close apposition of SLYM with the endothelial lining of the meningeal venous sinus permits direct exchange of small solutes between cerebrospinal fluid and venous blood, thus representing the mouse equivalent of the arachnoid granulations. The functional characterization of SLYM provides fundamental insights into brain immune barriers and fluid transport

U2 - 10.1126/science.adc8810

DO - 10.1126/science.adc8810

M3 - Journal article

C2 - 36603070

VL - 379

SP - 84

EP - 885

JO - Science

JF - Science

SN - 0036-8075

IS - 6627

ER -

ID: 331583800