All publications for Hajime Hirase, Ph.D.

(Updated April 30 2019)


Mishima M, Nagai T, Yahagi K, Akther S, Oe Y, Monai H, Kohsaka S, Hirase H (2019) Transcranial direct current stimulation (tDCS) induces adrenergic receptor-dependent microglial morphological changes in mice. eNeuro. DOI: 10.1523/ENEURO.0204-19.2019
Wu CH, Hung CY, Hirase H, Tain YL, Lee WC, Chan JYH, Fu, MH, Chen LW, Liu WC, Liang CK, Ho YH, Kung YC, L S, Wu KLH (2019) Pioglitazone reversed the fructose-programmed astrocytic glycolysis and oxidative phosphorylation, Am J Physiol Endocrinol Metab 316: E622-E634. DOI: 10.1152/ajpendo.00408.20180


Mestre H, Hablitz LM, Xavier ALB, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Rivera RMC, Simon MJ, Pike MM, Plá V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ, Nedergaard M (2018) Aquaporin-4-dependent glymphatic solute transport in the rodent brain. eLife 7:e40070. DOI: 10.7554/eLife.40070
Ue Y, Monai H, Higuchi K, Nishiwaki D, Tajima T, Okazaki K, Hama H, Hirase H, Miyawaki A (2018) A spherical aberration-free microscopy system for live brain imaging. Biochem Biophys Res Commun 126:15-21.


Tanaka M, Wang X, Mikoshiba K, Hirase H, Shinohara Y (2017) Hippocampal LFP changes by rearing condition and their dependence on inositol trisphosphate receptor type 2 in mice. J Physiol 595:6557-6568.
Harada K, Ito M, Wang X, Tanaka M, Wongso D, Konno A, Hirai H, Hirase H, Tsuboi T, Kitaguchi T (2017) Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging. Sci Rep 7:7351.
Nakai N, Nagano M, Saitow F, Watanbe Y, Kawamura Y, Kawamoto A, Tamada K, Mizuma H, Onoe H, Watanabe Y, Monai H, Hirase H, Nakatani J, Inagaki H, Kawada T, Miyazaki T, Watanabe M, Sato Y, Okabe S, Kitamura K, Kano M, Hashimoto K, Suzuki H, Takumi T (2017) Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice, Sci Adv. 3(6): e1603001.


Oe Y, Baba O, Ashida H, Nakamura KC, Hirase H (2016) Glycogen distribution in the microwave-fixed mouse brain reveals heterogeneous of astrocytic patterns. Glia 64:1532-1545.
Monai H, Ohkura M, Tanaka M, Oe Y, Konno A, Hirai H, Mikoshiba K, Itohara S, Nakai, J, Iwai Y, Hirase H (2016) Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain. Nature Commun 7:11100.


Nagai T, Takata N, Shinohara Y, Hirase H (2015) Adaptive changes of extracellular amino acid concentrations in mouse dorsal striatum by 4-AP-induced cortical seizures. Neuroscience 205: 229-236.
Aida T, Yoshida J, Nomura M, Tanimura A, Iino Y, Soma M, Bai N, Ito Y, Cui W, Aizawa H, Yanagisawa M, Nagai T, Takata N, Tanaka K, Takayanagi R, Kano M, Gotz M, Hirase H, Tanaka K (2015) Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice. Neuropsychopharmacology 40:1569-1579.


Hashimoto M, Hata A, Miyata T, Hirase H (2014), Programmable and wireless LED-stimulator for chronic stimulation of optogenetic molecules in freely moving mice. Neurophotonics 1:011002.


Takata N, Nagai T, Ozawa K, Oe Y, Mikoshiba K, Hirase H (2013) Cerebral blood flow modulation by basal forebrain or whisker stimulation can occur independently of large cytosolic Ca2+ signaling in astrocytes. PLoS One 8:e66525.
Shinohara Y, Hosoya A, Hirase H (2013) Experience enhances gamma oscillations and interhemispheric asymmetry in the hippocampus. Nature Commun 4:1652.


Molter C, O’Neill J, Yamaguchi Y, Hirase H, Leinekugel X (2012) Rhythmic modulation of theta oscillations supports encoding of spatial and behavioral information in the rat hippocampus. Neuron 75:889-903.
Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takahashi T (2012) Disruption of cortical function underlies behavior dysfunction due to social isolation. J Clin Invest 122:2690-2701.
Hirase H, Nikolenko V, Yuste R (2012) Multiphoton stimulation of neurons and spines. Cold Spring Harb Protoc. 2012(4):472-5.
Shinohara Y, Hosoya A, Yahagi K, Ferecsko AS, Yaguchi K, Sik A, Itakura M, Takahashi M, Hirase H (2012) Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents. Eur J Neurosci 35: 702-710.


Takata N, Mishima T, Hisatsune C, Nagai T, Eibusi E, Mikoshiba K, Hirase H (2011) Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo. J Neurosci 31:18155-18165.
Kaneko M, Yamaguchi K, Eiraku M, Takata N, Kiyohara Y, Mishina M, Hirase H, Hashikawa T, Kengaku M (2011) Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation. PLoS One 6:e20108.
Shinohara Y, Yahagi K, Kawano M, Nishiyori H, Kawazu C, Suzuki N, Manabe R, Hirase H (2011) miRNA profiling of bilateral rat hippocampal CA3 by deep sequencing. Biochem Biophys Res Commun 409:293-298.
Iwai Y, Honda S, Ozeki H, Hashimoto M, Hirase H (2011) A simple head-mountable LED device for chronic stimulation of optogenetic molecules in freely moving mice. Neurosci Res 70:124-127.


Mishima T, Hirase H (2010) In vivo intracellular recording suggests that gray matter astrocytes in mature cerebral cortex and hippocampus are electrophysiologically homogeneous. J Neurosci 30:3093-3100.


Sakatani S, Yamada K, Homma C, Munesue S, Yamamoto Y, Yamamoto H, Hirase H (2009) Deletion of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice. PLoS One 4:e8309.


Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R (2008) Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors. Proc Natl Acad Sci U S A 105:19498-19503.
Sakatani S, Seto-Ohshima A, Shinohara Y, Yamamoto Y, Yamamoto H, Itohara S, Hirase H (2008) Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo. J Neurosci 28:10928-10936.
Takata N, Hirase H (2008) Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo. PLoS One 3:e2525.


Mishima T, Sakatani S, Hirase H (2007) Intracellular labeling of single cortical astrocytes in vivo. J Neurosci Methods 166:32-40.
Sakatani S, Seto-Ohshima A, Itohara S, Hirase H (2007) Impact of S100B on local field potential patterns in anesthetized and kainic acid-induced seizure conditions in vivo. Eur J Neurosci 25:1144-1154.


Gulyas AI, Buzsaki G, Freund TF, Hirase H (2006) Populations of hippocampal inhibitory neurons express different levels of cytochrome c. Eur J Neurosci 23:2581-2594.


Hirase H, Creso J, Buzsaki G (2004) Capillary level imaging of local cerebral blood flow in bicuculline-induced epileptic foci. Neuroscience 128:209-216.
Bartho P, Hirase H, Monconduit L, Zugaro M, Harris KD, Buzsaki G (2004) Characterization of neocortical principal cells and interneurons by network interactions and extracellular features. J Neurophysiol 92:600-608.
Hirase H, Qian L, Bartho P, Buzsaki G (2004) Calcium dynamics of cortical astrocytic networks in vivo. PLoS Biol 2:E96.
Hirase H, Creso J, Singleton M, Bartho P, Buzsaki G (2004) Two-photon imaging of brain pericytes in vivo using dextran-conjugated dyes. Glia 46:95-100.


Harris KD, Csicsvari J, Hirase H, Dragoi G, Buzsaki G (2003) Organization of cell assemblies in the hippocampus. Nature 424:552-556.


Leinekugel X, Khazipov R, Cannon R, Hirase H, Ben-Ari Y, Buzsaki G (2002) Correlated bursts of activity in the neonatal hippocampus in vivo. Science 296:2049-2052.
Harris KD, Henze DA, Hirase H, Leinekugel X, Dragoi G, Czurko A, Buzsaki G (2002) Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells. Nature 417:738-741.
Marshall L, Henze DA, Hirase H, Leinekugel X, Dragoi G, Buzsaki G (2002) Hippocampal pyramidal cell-interneuron spike transmission is frequency dependent and responsible for place modulation of interneuron discharge. J Neurosci 22:RC197.
Hirase H, Nikolenko V, Goldberg JH, Yuste R (2002) Multiphoton stimulation of neurons. J Neurobiol 51:237-247.


Harris KD, Hirase H, Leinekugel X, Henze DA, Buzsaki G (2001) Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells. Neuron 32:141-149.
Hirase H, Leinekugel X, Czurko A, Csicsvari J, Buzsaki G (2001) Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. Proc Natl Acad Sci U S A 98:9386-9390.
Hirase H, Leinekugel X, Csicsvari J, Czurko A, Buzsaki G (2001) Behavior-dependent states of the hippocampal network affect functional clustering of neurons. J Neurosci 21:RC145.
Szabo I, Czurko A, Csicsvari J, Hirase H, Leinekugel X, Buzsaki G (2001) The application of printed circuit board technology for fabrication of multi-channel micro-drives. J Neurosci Methods 105:105-110.


Csicsvari J, Hirase H, Mamiya A, Buzsaki G (2000) Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events. Neuron 28:585-594.
Harris KD, Henze DA, Csicsvari J, Hirase H, Buzsaki G (2000) Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements. J Neurophysiol 84:401-414.


Hirase H, Czurko A, Csicsvari J, Buzsaki G (1999) Firing rate and theta-phase coding by hippocampal pyramidal neurons during 'space clamping'. Eur J Neurosci 11:4373-4380.
Nadasdy Z, Hirase H, Czurko A, Csicsvari J, Buzsaki G (1999) Replay and time compression of recurring spike sequences in the hippocampus. J Neurosci 19:9497-9507.
Csicsvari J, Hirase H, Czurko A, Mamiya A, Buzsaki G (1999) Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving Rat. J Neurosci 19:274-287.
Csicsvari J, Hirase H, Czurko A, Mamiya A, Buzsaki G (1999) Fast network oscillations in the hippocampal CA1 region of the behaving rat. J Neurosci 19:RC20.
Czurko A, Hirase H, Csicsvari J, Buzsaki G (1999) Sustained activation of hippocampal pyramidal cells by 'space clamping' in a running wheel. Eur J Neurosci 11:344-352.


Csicsvari J, Hirase H, Czurko A, Buzsaki G (1998) Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat. Neuron 21:179-189.


Hirase H, Recce M, (1996) A search for the optimal thresholding sequence in an associative memory. Network: Computation in Neural Systems 7: 741-758