The Ocular Glymphatic System—Current Understanding and Future Perspectives
Research output: Contribution to journal › Review › Research › peer-review
Documents
- Fulltext
Final published version, 1.91 MB, PDF document
The ocular glymphatic system subserves the bidirectional polarized fluid transport in the optic nerve, whereby cerebrospinal fluid from the brain is directed along periarterial spaces towards the eye, and fluid from the retina is directed along perivenous spaces following upon its axonal transport across the glial lamina. Fluid homeostasis and waste removal are vital for retinal function, making the ocular glymphatic fluid pathway a potential route for targeted manipulation to combat blinding ocular diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Several lines of work investigating the bidirectional ocular glymphatic transport with varying methodologies have developed diverging mechanistic models, which has created some confusion about how ocular glymphatic transport should be defined. In this review, we provide a comprehensive summary of the current understanding of the ocular glymphatic system, aiming to address misconceptions and foster a cohesive understanding of the topic.
Original language | English |
---|---|
Article number | 5734 |
Journal | International Journal of Molecular Sciences |
Volume | 25 |
Issue number | 11 |
Number of pages | 12 |
ISSN | 1661-6596 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
Publisher Copyright:
© 2024 by the authors.
- amyloid-beta, aquaporin-4, blood–retinal barrier, cerebrospinal fluid, diabetes, glaucoma, glymphatic–lymphatic fluid transport, intracranial pressure, intraocular pressure, meningeal lymphatics, perivascular spaces
Research areas
ID: 395392073