The Ocular Glymphatic System—Current Understanding and Future Perspectives
Research output: Contribution to journal › Review › Research › peer-review
Standard
The Ocular Glymphatic System—Current Understanding and Future Perspectives. / Delle, Christine; Wang, Xiaowei; Nedergaard, Maiken.
In: International Journal of Molecular Sciences, Vol. 25, No. 11, 5734, 2024.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The Ocular Glymphatic System—Current Understanding and Future Perspectives
AU - Delle, Christine
AU - Wang, Xiaowei
AU - Nedergaard, Maiken
N1 - Publisher Copyright: © 2024 by the authors.
PY - 2024
Y1 - 2024
N2 - The ocular glymphatic system subserves the bidirectional polarized fluid transport in the optic nerve, whereby cerebrospinal fluid from the brain is directed along periarterial spaces towards the eye, and fluid from the retina is directed along perivenous spaces following upon its axonal transport across the glial lamina. Fluid homeostasis and waste removal are vital for retinal function, making the ocular glymphatic fluid pathway a potential route for targeted manipulation to combat blinding ocular diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Several lines of work investigating the bidirectional ocular glymphatic transport with varying methodologies have developed diverging mechanistic models, which has created some confusion about how ocular glymphatic transport should be defined. In this review, we provide a comprehensive summary of the current understanding of the ocular glymphatic system, aiming to address misconceptions and foster a cohesive understanding of the topic.
AB - The ocular glymphatic system subserves the bidirectional polarized fluid transport in the optic nerve, whereby cerebrospinal fluid from the brain is directed along periarterial spaces towards the eye, and fluid from the retina is directed along perivenous spaces following upon its axonal transport across the glial lamina. Fluid homeostasis and waste removal are vital for retinal function, making the ocular glymphatic fluid pathway a potential route for targeted manipulation to combat blinding ocular diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Several lines of work investigating the bidirectional ocular glymphatic transport with varying methodologies have developed diverging mechanistic models, which has created some confusion about how ocular glymphatic transport should be defined. In this review, we provide a comprehensive summary of the current understanding of the ocular glymphatic system, aiming to address misconceptions and foster a cohesive understanding of the topic.
KW - amyloid-beta
KW - aquaporin-4
KW - blood–retinal barrier
KW - cerebrospinal fluid
KW - diabetes
KW - glaucoma
KW - glymphatic–lymphatic fluid transport
KW - intracranial pressure
KW - intraocular pressure
KW - meningeal lymphatics
KW - perivascular spaces
U2 - 10.3390/ijms25115734
DO - 10.3390/ijms25115734
M3 - Review
C2 - 38891923
AN - SCOPUS:85195845412
VL - 25
JO - International Journal of Molecular Sciences (Online)
JF - International Journal of Molecular Sciences (Online)
SN - 1661-6596
IS - 11
M1 - 5734
ER -
ID: 395392073