Center for Translational Neuromedicine

  1. Published

    Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells

    Major, T., Powers, A. & Tabar, V., Nov 2016, In: Current Protocols in Stem Cell Biology. 39, 1, p. 1H.10.1-1H.10.23 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity

    Madsen, M. K., Petersen, A. S., Stenbæk, Dea Siggaard, Sorensen, I. M., Schionning, H., Fjeld, T., Nykjaer, C., Larsen, S. M. U., Grzywacz, M., Mathiesen, T., Klausen, I., Hansen, O. O., Brendstrup-Brix, K., Linnet, Kristian, Johansen, Sys Stybe, Fisher, P. M., Jensen, Rasmus Herlo Beenfeldt, Knudsen, Gitte Moos & Madsen, M. K., 2022, medRxiv, 17 p.

    Research output: Working paperPreprintResearch

  3. Published

    Glymphatic clearance controls state-dependent changes in brain lactate concentration

    Lundgaard, I., Lu, M. L., Yang, E., Peng, W., Mestre, H., Hitomi, E., Deane, R. & Nedergaard, Maiken, Jun 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 6, p. 2112-2124 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Direct neuronal glucose uptake Heralds activity-dependent increases in cerebral metabolism

    Lundgaard, I., Li, B., Xie, L., Kang, H., Sanggaard, S., Haswell, J. D. R., Sun, W., Goldman, S., Blekot, S., Nielsen, Michael Lund, Takano, T., Deane, R. & Nedergaard, Maiken, 2015, In: Nature Communications. 6, 12 p., 6807.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

    Lundgaard, I., Wang, W., Eberhardt, A., Vinitsky, H. S., Reeves, B. C., Peng, S., Lou, N., Hussain, R. & Nedergaard, Maiken, 2018, In: Scientific Reports. 8, 1, 16 p., 2246.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update

    Lovell-Badge, R., Anthony, E., Barker, R. A., Bubela, T., Brivanlou, A. H., Carpenter, M., Charo, R. A., Clark, A., Clayton, E., Cong, Y., Daley, G. Q., Fu, J., Fujita, M., Greenfield, A., Goldman, S. A., Hill, L., Hyun, I., Isasi, R., Kahn, J., Kato, K. & 27 others, Kim, J. S., Kimmelman, J., Knoblich, J. A., Mathews, D., Montserrat, N., Mosher, J., Munsie, M., Nakauchi, H., Naldini, L., Naughton, G., Niakan, K., Ogbogu, U., Pedersen, R., Rivron, N., Rooke, H., Rossant, J., Round, J., Saitou, M., Sipp, D., Steffann, J., Sugarman, J., Surani, A., Takahashi, J., Tang, F., Turner, L., Zettler, P. J. & Zhai, X., 2021, In: Stem Cell Reports. 16, 6, p. 1398-1408 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  7. Published

    Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

    Louveau, A., Plog, B. A., Antila, S., Alitalo, K., Nedergaard, Maiken & Kipnis, J., 1 Sep 2017, In: The Journal of Clinical Investigation. 127, 9, p. 3210-3219 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  8. Published

    Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier

    Lou, N., Takano, T., Pei, Y., L R Xavier, Anna , Goldman, Steven Alan & Nedergaard, Maiken, 26 Jan 2016, In: National Academy of Sciences. Proceedings. 113, 4, p. 1074-1079 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

    Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Pretargeted Imaging beyond the Blood–Brain Barrier: Utopia or Feasible?

    Lopes van den Broek, S., Shalgunov, Vladimir, García Vázquez, R., Beschorner, Natalie, Bidesi, N. S. R., Nedergaard, Maiken, Knudsen, Gitte Moos, Sehlin, D., Syvänen, S. & Herth, Matthias Manfred, 2022, In: Pharmaceuticals. 15, 10, 13 p., 1191.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters

    Lolansen, Sara Diana, Rostgaard, Nina, Barbuskaite, Dagne, Capion, T., Olsen, M. H., Norager, N. H., Vilhardt, Frederik, Andreassen, Søren Norge, Toft-Bertelsen, Trine Lisberg, Ye, F., Juhler, Marianne, Keep, R. F. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 19 p., 62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The glymphatic system: implications for drugs for central nervous system diseases

    Lohela, T. J., Lilius, T. O. & Nedergaard, Maiken, 2022, In: Nature Reviews Drug Discovery. 21, 10, p. 763-779 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling

    Liu, Z., Osipovitch, M., Benraiss, A., Huynh, N. P. T., Foti, R., Bates, J., Chandler-Militello, D., Findling, R. L., Tesar, P. J., Nedergaard, Maiken, Windrem, M. S. & Goldman, Steven Alan, 2019, In: Cell Reports. 27, 13, p. 3832-3843, e1-e6

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Uncovering the anatomical and molecular landscape of the developing entorhinal cortex.

    Liu, Y., Bergmann, T. B., Peralvo Vidal, Juan Miguel, Lee, J., Mori, Yuki, Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Gorodkin, Jan, Hyttel, P., Pers, Tune H, witter, M. & Hall, Vanessa Jane, 2018.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  15. Published

    Development of the entorhinal cortex occurs via parallel lamination during neurogenesis

    Liu, Y., Bergmann, T., Mori, Yuki, Peralvo Vidal, Juan Miguel, Pihl, M., Vasistha, Navneet A, Thomsen, Preben Dybdahl, Seemann, Ernst Stefan, Gorodkin, Jan, Hyttel, P., Khodosevich, Konstantin, Witter, M. P. & Hall, Vanessa Jane, 2021, In: Frontiers in Neuroanatomy. 15, 19 p., 663667.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Sandwich cortial lamination and single-cell analysis decodes the developing spatial processing system

    Liu, Y., Bergmann, T. B., Lee, J., Pfisterer, U. G., Handfield, L-F., Mori, Y., Asenjo Martinez, A., Lisa Vargas, I., Seemann, E. S., Lee, J. T. H., Patikis, N., Peralvo Vidal, J. M., Pihl, M., Kornum, B. R., Thomsen, P. D., Hyttel, P., Witter, M., Khodosevich, K., Gorodkin, J., Hemberg, M. & 2 others, Pers, Tune H & Hall, Vanessa Jane, 2019. 45 p.

    Research output: Contribution to conferencePaperCommunication

  17. Published

    Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies

    Liu, G., Ladrón-de-Guevara, A., Izhiman, Y., Nedergaard, Maiken & Du, Ting, 2022, In: Fluids and Barriers of the CNS. 19, 1, 24 p., 101.

    Research output: Contribution to journalReviewResearchpeer-review

  18. Published

    Direct Measurement of Cerebrospinal Fluid Production in Mice

    Liu, G., Mestre, H., Sweeney, A. M., Sun, Q., Weikop, Pia, Du, T. & Nedergaard, Maiken, 2020, In: Cell Reports. 33, 12, 13 p., 108524.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

    Lilius, T. O., Blomqvist, K., Hauglund, Natalie Linea, Liu, G., Stæger, Frederik Filip Vinggaard, Baerentzen, S., Du, T., Ahlstrom, F., Backman, J. T., Kalso, E. A., Rauhala, P. V. & Nedergaard, Maiken, 2019, In: Journal of Controlled Release. 304, p. 29-38 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles

    Lilius, T. O., Mortensen, K. N., Deville, C., Lohela, T. J., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Fiordaliso, E. M., Rosenholm, Marko, Kamphuis, C., Beekman, F. J., Jensen, A. I. & Nedergaard, Maiken, 2023, In: Journal of Controlled Release. 355, p. 135-148 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

    Lilius, T. O., Rosenholm, Marko, Klinger, L., Mortensen, K. N., Sigurdsson, B., Mogensen, F. L., Hauglund, Natalie Linea, Nielsen, Malthe Skytte Nordentoft, Rantamaki, T. & Nedergaard, Maiken, 2022, In: iScience. 25, 10, 17 p., 105250.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

    Liang, Q., Luo, Z., Zeng, J., Chen, W., Foo, S., Lee, S., Ge, J., Wang, S., Goldman, Steven Alan, Zlokovic, B. V., Zhao, Z. & Jung, J. U., 3 Nov 2016, In: Cell Stem Cell. 19, 5, p. 663-671 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Aquaporin 1 and the Na+/K+/2Cl- cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system

    Li, Q., Aalling, Nadia, Förstera, B., Ertürk, A., Nedergaard, Maiken, Møllgård, Kjeld & L R Xavier, Anna , 2020, In: Fluids and Barriers of the CNS. 17, 15 p., 15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

    Li, J., Pan, L., Godoy, M., Pembroke, W. G., Rexach, J. E., Condro, M. C., Alvarado, A. G., Harteni, M., Chen, Y., Stiles, L., Chen, A. Y., Wanner, I. B., Yang, X., Goldman, Steven Alan, Geschwind, D. H., Kornblum, H. & Zhang, Y., 2021, In: Nature Communications. 12, 1, 20 p., 3958.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

    Li, J., Pan, L., Pembroke, W. G., Rexach, J. E., Godoy, M. I., Condro, M. C., Alvarado, A. G., Harteni, M., Chen, Y., Stiles, L., Chen, A. Y., Wanner, I. B., Yang, X., Goldman, Steven Alan, Geschwind, D. H., Kornblum, H. I. & Zhang, Y., 2021, p. E172-E173. 2 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  26. Published

    Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T

    Lee, H., Mortensen, K., Sanggaard, S., Koch, P., Brunner, H., Quistorff, B., Nedergaard, Maiken & Benveniste, H., 2018, In: Magnetic Resonance in Medicine. 79, 3, p. 1568-1578 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Astrocyte Specific Remodeling of Plasmalemmal Cholesterol Composition by Ketamine Indicates a New Mechanism of Antidepressant Action

    Lasic, E., Lisjak, M., Horvat, A., Bozic, M., Sakanovic, A., Anderluh, G., Verkhratsky, A., Vardjan, N., Jorgacevski, J., Stenovec, M. & Zorec, R., 2019, In: Scientific Reports. 9, 12 p., 10957.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep

    Larsen, S. M. U., Landolt, H. P., Berger, W., Nedergaard, Maiken, Knudsen, Gitte Moos & Holst, S. C., May 2020, In: PLOS Biology. 18, 5, 14 p., e3000623.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    NREM sleep upregulates human brain pulsation detected by Ultrafast Magnetic Resonance Encephalography

    Larsen, S. M. U., Holst, S. C., Olsen, A. S., Zilstorff, D. B., Pleinert, S., Kiviniemi, V., Jennum, Poul, Nedergaard, Maiken & Knudsen, Gitte Moos, 2021, In: European Neuropsychopharmacology. 53, p. S361-S362 3 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  30. Published

    Genetic haplotype of the glymphatic-associated water channel aquaporin 4 modulates slow waves in human non-rapid eye movement sleep

    Larsen, S. M. U., Landolt, H. P., Berger, W., Nedergaard, Maiken, Knudsen, Gitte Moos & Holst, S. C., 2019, In: European Neuropsychopharmacology. 29, Supplement 6, p. S563-S564 2 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  31. Published

    Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses

    Larsen, B. R., Assentoft, M., Cotrina, M. L., Hua, S. Z., Nedergaard, Maiken, Kaila, K., Voipio, J. & MacAulay, Nanna, Apr 2014, In: Glia. 62, 4, p. 608-22 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment

    Ladrón-de-Guevara, A., Shang, J. K., Nedergaard, Maiken & Kelley, D. H., 2022, In: Journal of Theoretical Biology. 542, 111103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Effect of Home-Based High-Intensity Interval Training in Patients With Lacunar Stroke: A Randomized Controlled Trial

    Krawcyk, R. S., Vinther, A., Petersen, Nicolas Caesar, Faber, Jens, Iversen, Helle Klingenberg, Christensen, T., Lambertsen, K. L., Rehman, S., Klausen, T. W., Rostrup, E. & Kruuse, Christina Rostrup, 2019, In: Frontiers in Neurology. 10, 15 p., 664.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Home-based aerobic exercise in patients with lacunar stroke: Design of the HITPALS randomized controlled trial

    Krawcyk, R. S., Vinther, A., Petersen, Nicolas Caesar, Faber, Jens, Hansen, R. H., Rostrup, E. & Kruuse, Christina Rostrup, 2019, In: Contemporary Clinical Trials Communications. 14, 9 p., 100332.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Self-Reported Physical Activity and Cardiovascular Disease Risk Factors in Patients with Lacunar Stroke

    Krawcyk, R. S., Vinther, A., Petersen, Nicolas Caesar, Faber, Jens, Rehman, S., Iversen, Helle Klingenberg, Christensen, T. & Kruuse, Christina Rostrup, 2019, In: Journal of Stroke & Cerebrovascular Diseases. 28, 8, p. 2168-2176 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    EARLY INTRODUCTION TO HIGH-INTENSITY INTERVAL TRAINING IN STROKE ASSOCIATES WITH SUSTAINED VIGOROUS-INTENSITY ACTIVITY AT LONG-TERM FOLLOW-UP - RESULTS FROM THE HITPALS STUDY

    Krawcyk, R. S., Vinther, A., Petersen, Nicolas Caesar, Faber, Jens, Iversen, Helle Klingenberg, Christensen, T., Lambertsen, K., Klausen, T., Rostrup, E. & Kruuse, Christina Rostrup, 2020, In: International Journal of Stroke. 15, Supplement 1, p. 132 00477 / #2449.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  37. Published

    Increased activity of glial glutamate transporter-associated anion channels results in episodic ataxia 6

    Kovermann, P., Untiet, Verena, Kolobkova, Y. & Fahlke, C., 2019, In: Glia. 67, S1, p. E216 1 p., T05-034A.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  38. Published

    Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI

    Koundal, S., Liu, X., Sanggaard, S., Mortensen, K., Wardlaw, J., Nedergaard, Maiken, Benveniste, H. & Lee, H., 2019, In: Neuroscience. 404, p. 14-26

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Human glial chimeric mice reveal astrocytic dependence of JC virus infection

    Kondo, Y., Windrem, M. S., Zou, L., Chandler-Militello, D., Schanz, S. J., Auvergne, R. M., Betstadt, S. J., Harrington, A. R., Johnson, M., Kazarov, A., Gorelik, L. & Goldman, Steven Alan, 1 Dec 2014, In: The Journal of Clinical Investigation. 124, 12, p. 5323-36 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Introducing the special issue on “Proteins and Circuits in Memory”

    Kjærgaard, M., Petersen, Nicolas Caesar, Sørensen, Jakob Balslev & Takeuchi, T., 2021, In: European Journal of Neuroscience. 54, 8, p. 6691-6695 5 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  41. Published

    Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

    Kjærby, Celia, Rasmussen, R., Andersen, Mie & Nedergaard, Maiken, Jun 2017, In: Neurochemical Research. 42, 6, p. 1810-1822 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

    Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2022, In: Nature Neuroscience. 25, p. 1059–1070 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Impaired GABAergic Inhibition in the Prefrontal Cortex of Early Postnatal Phencyclidine (PCP)-Treated Rats

    Kjærby, Celia, Broberg, B. V., Kristiansen, Uffe & Dalby, N. O., 2014, In: Cerebral Cortex. 24, 9, p. 2522-32 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Dynamic fluctuations of the locus coeruleus-norepinephrine system underlie sleep state transitions

    Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Ding, F., Wang, W., Xu, Q., Deng, S., Kang, N., Peng, S., Sun, Q., Dall, C., Jørgensen, P. K., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2 Sep 2020, 1 p.

    Research output: Other contributionResearch

  45. Published

    Reply to: 'Do all norepinephrine surges disrupt sleep?'

    Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Ding, F., Hirase, Hajime & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  46. Published

    Donor cell memory confers a metastable state of directly converted cells

    Kim, K. P., Li, C., Bunina, D., Jeong, H. W., Ghelman, J., Yoon, J., Shin, B., Park, H., Han, D. W., Zaugg, J. B., Kim, J., Kuhlmann, T., Adams, R. H., Noh, K. M., Goldman, Steven Alan & Schöler, H. R., 2021, In: Cell Stem Cell. 28, 7, p. 1291-1306.e10 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats

    Kiilerich, K. F., Lorenz, J., Scharff, M. B., Speth, N., Brandt, T. G., Czurylo, J., Xiong, M., Jessen, N. S., Casado-Sainz, A., Shalgunov, Vladimir, Kjærby, Celia, Satała, G., Bojarski, A. J., Jensen, Anders A., Herth, Matthias Manfred, Cumming, P., Overgaard, A. & Palner, M., 2023, In: Molecular Psychiatry. 28, 9, p. 3829-3841

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Astrocytic contributions to Huntington's disease pathophysiology

    Khakh, B. S. & Goldman, Steven Alan, 2023, In: Annals of the New York Academy of Sciences. 1522, 1, p. 42-59 18 p.

    Research output: Contribution to journalReviewResearchpeer-review

  49. Published

    Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease

    Khakh, B. S., Beaumont, V., Cachope, R., Munoz-Sanjuan, I., Goldman, Steven Alan & Grantyn, R., Jul 2017, In: Trends in Neurosciences. 40, 7, p. 422-437 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  50. Published

    An immortalized human adipose-derived stem cell line with highly enhanced chondrogenic properties

    Katz, D. B., Huynh, N. P. T., Savadipour, A., Palte, I. & Guilak, F., 2020, In: Biochemical and Biophysical Research Communications. 530, 1, p. 252-258 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review