Hajime Hirase

Hajime Hirase

Professor


  1. 2024
  2. E-pub ahead of print

    Anxiety control by astrocytes in the lateral habenula

    Tan, W., Ikoma, Y., Takahashi, Y., Konno, A., Hirai, H., Hirase, Hajime & Matsui, K., 2024, (E-pub ahead of print) In: Neuroscience Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats

    Wu, K. L. H., Liu, W. C., Wu, C. W., Fu, M. H., Huang, H. M., Tain, Y. L., Liang, C. K., Hung, C. Y., Chen, I. C., Hung, P. L., Lin, Y. J. & Hirase, Hajime, 2024, In: Journal of Nutritional Biochemistry. 126, 14 p., 109571.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Oxygen imaging of hypoxic pockets in the mouse cerebral cortex

    Beinlich, Felix Ralf Michael, Asiminas, Antonios, Untiet, Verena, Bojarowska, Zuzanna, Pla Requena, Virginia Teresa, Sigurdsson, B., Timmel, V., Gehrig, L., Graber, M. H., Hirase, Hajime & Nedergaard, Maiken, 2024, In: Science (New York, N.Y.). 383, 6690, p. 1471-1478 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2023
  6. Published

    A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life

    Wu, S-Y., Wen, Y., Serre, N. B. C., Laursen, C. C. H., Dietz, A. G., Taylor, B. R., Drobizhev, M., Molina, R. S., Aggarwal, A., Rancic, V., Becker, M., Ballanyi, K., Podgorski, K., Hirase, H., Nedergaard, M., Fendrych, M., Lemieux, M. J., Eberl, D. F., Kay, A. R., Campbell, R. E. & 1 others, Shen, Y., 2023, In: PLOS Biology. 20, 9, 23 p., e3001772.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes

    Ozawa, K., Nagao, Masaki, Konno, A., Iwai, Y., Vittani, Marta, Kusk, P., Mishima, Tsuneko, Hirai, H., Nedergaard, Maiken & Hirase, Hajime, 2023, In: International Journal of Molecular Sciences. 24, 17, 12 p., 13590.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice

    Untiet, Verena, Beinlich, Felix Ralf Michael, Kusk, P., Kang, N., Ladrón-de-Guevara, A., Song, W., Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Bojarowska, Zuzanna, Sigurdsson, B., Deng, S., Hirase, Hajime, Petersen, Nicolas Caesar, Verkhratsky, A. & Nedergaard, Maiken, 2023, In: Nature Communications. 14, 1, 14 p., 1871.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype

    Takahashi, K., Kanekiyo, K., Sakuda, K., Muto, Y., Iguchi, M., Matsuda, N., Hashimoto, Y., Kanai, K., Ogawa, H., Hirase, Hajime, Kakita, A., Bizen, N., Takebayashi, H., Kawaguchi, Y., Uzuki, M. & Kitazume, S., 2023, In: Journal of Neurochemistry. 166, 3, 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging

    Nasu, Y., Aggarwal, A., Le, G. N. T., Vo, C. T., Kambe, Y., Wang, X., Beinlich, F. R. M., Lee, A. B., Ram, T. R., Wang, F., Gorzo, K. A., Kamijo, Y., Boisvert, M., Nishinami, S., Kawamura, G., Ozawa, T., Toda, H., Gordon, G. R., Ge, S., Hirase, H. & 5 others, Nedergaard, Maiken, Paquet, M. E., Drobizhev, M., Podgorski, K. & Campbell, R. E., 2023, In: Nature Communications. 14, 1, 17 p., 6598.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output

    Dietz, Andrea Grostøl, Weikop, Pia, Hauglund, Natalie Linea, Andersen, Mie, Petersen, Nicolas Caesar, Rose, Laura, Hirase, Hajime & Nedergaard, Maiken, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 40, 9 p., e2305071120.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Locomotion Induces Fundamentally Different Patterns of Ca2+Signaling in Astrocytes and Neurons

    Hirase, Hajime & Nedergaard, Maiken, 2023, In: Function. 4, 4, 2 p., zqad028.

    Research output: Contribution to journalComment/debateResearchpeer-review

  13. Published

    Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema

    Hussain, R., Tithof, J., Wang, W., Cheetham-West, A., Song, W., Peng, W., Sigurdsson, B., Kim, D., Sun, Q., Peng, S., Pla Requena, Virginia Teresa, Kelley, D. H., Hirase, Hajime, Castorena-Gonzalez, J. A., Weikop, Pia, Goldman, Steven Alan, Davis, M. J. & Nedergaard, Maiken, 2023, In: Nature. 623, p. 992–1000 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Reply to: 'Do all norepinephrine surges disrupt sleep?'

    Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Ding, F., Hirase, Hajime & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  15. 2022
  16. Published

    Assessment of astrocytes as a mediator of memory and learning in rodents

    Akther, S. & Hirase, Hajime, 2022, In: Glia. 70, 8, p. 1484-1505 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

    Du, T., Mestre, H., Kress, B. T., Liu, G., Sweeney, A. M., Samson, A. J., Rasmussen, M. K., Mortensen, K. N., Bork, P. A. R., Peng, W., Olveda, G. E., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Hirase, H. & 2 others, Mori, Yuki & Nedergaard, Maiken, 2022, In: Brain. 145, 2, p. 787–797 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Depth-targeted intracortical microstroke by two-photon photothrombosis in rodent brain

    Fukuda, M., Matsumura, T., Suda, T. & Hirase, Hajime, 2022, In: Neurophotonics. 9, 2, 9 p., 021910.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation

    Wang, Xiaowen, Delle, Christine, Asiminas, Antonios, Akther, S., Vittani, Marta, Brøgger, Peter, Kusk, P., Vo, C. T., Radovanovic, Tessa, Konno, A., Hirai, H., Fukuda, M., Weikop, Pia, Goldman, Steven Alan, Nedergaard, Maiken & Hirase, Hajime, 2022, In: Cell Reports Methods. 2, 10, 16 p., 100302.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

    Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2022, In: Nature Neuroscience. 25, p. 1059–1070 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2021
  22. A Rationally and Computationally Designed Fluorescent Biosensor for d -Serine

    Vongsouthi, V., Whitfield, J. H., Unichenko, P., Mitchell, J. A., Breithausen, B., Khersonsky, O., Kremers, L., Janovjak, H., Monai, H., Hirase, Hajime, Fleishman, S. J., Henneberger, C. & Jackson, C. J., 2021, In: ACS Sensors. 6, 11, p. 4193-4205 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization

    Monai, H., Koketsu, S., Shinohara, Y., Ueki, T., Kusk, P., Hauglund, Natalie Linea, Samson, A. J., Nedergaard, Maiken & Hirase, Hajime, 2021, In: Scientific Reports. 11, 1, 8150.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo

    Dubanet, O., Da Silva, A. F. G., Frick, A., Hirase, Hajime, Beyeler, A. & Leinekugel, X., 2021, In: Cell Reports. 36, 2, 19 p., 109381.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice

    Sugimoto, H., Horii, T., Hirota, J. N., Sano, Y., Shinoda, Y., Konno, A., Hirai, H., Ishizaki, Y., Hirase, Hajime, Hatada, I., Furuichi, T. & Sadakata, T., 2021, In: Molecular Brain. 14, 1, 9 p., 52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement

    Iwai, Y., Ozawa, K., Yahagi, K., Mishima, Tsuneko, Akther, S., Vo, C. T., Lee, Ashley Bomin, Tanaka, M., Itohara, S. & Hirase, Hajime, 2021, In: Frontiers in Neural Circuits. 15, 16 p., 658343.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2020
  28. Published

    Dynamic fluctuations of the locus coeruleus-norepinephrine system underlie sleep state transitions

    Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Ding, F., Wang, W., Xu, Q., Deng, S., Kang, N., Peng, S., Sun, Q., Dall, C., Jørgensen, P. K., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2 Sep 2020, 1 p.

    Research output: Other contributionResearch

  29. Published

    A community-based transcriptomics classification and nomenclature of neocortical cell types

    Yuste, R., Hawrylycz, M., Aalling, N., Aguilar-valles, A., Arendt, D., Arnedillo, R. A., Ascoli, G. A., Bielza, C., Bokharaie, V., Bergmann, T. B., Bystron, I., Capogna, M., Chang, Y., Clemens, A., De Kock, C. P. J., Defelipe, J., Dos Santos, S. E., Dunville, K., Feldmeyer, D., Fiáth, R. & 53 others, Fishell, G. J., Foggetti, A., Gao, X., Ghaderi, P., Goriounova, N. A., Güntürkün, O., Hagihara, K., Hall, Vanessa Jane, Helmstaedter, M., Herculano, S., Hilscher, M. M., Hirase, Hajime, Hjerling-leffler, J., Hodge, R., Huang, J., Huda, R., Khodosevich, Konstantin, Kiehn, Ole, Koch, H., Kuebler, E. S., Kühnemund, M., Larrañaga, P., Lelieveldt, B., Louth, E. L., Lui, J. H., Mansvelder, H. D., Marin, O., Martinez-trujillo, J., Moradi Chameh, H., Nath, A., Nedergaard, M., Němec, P., Ofer, N., Pfisterer, U. G., Pontes, S., Redmond, W., Rossier, J., Sanes, J. R., Scheuermann, R., Serrano-saiz, E., Steiger, J. F., Somogyi, P., Tamás, G., Tolias, A. S., Tosches, M. A., García, M. T., Vieira, H. M., Wozny, C., Wuttke, T. V., Yong, L., Yuan, J., Zeng, H. & Lein, E., 2020, In: Nature Neuroscience. 23, p. 1456-1468 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices

    Stæger, Frederik Filip Vinggaard, Mortensen, K. N., Nielsen, M. S. N., Sigurdsson, B., Kaufmann, L. K., Hirase, Hajime & Nedergaard, Maiken, 2020, In: Scientific Data. 7, 1, 7 p., 235.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Cerebrospinal fluid influx drives acute ischemic tissue swelling

    Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P., Kleinfeld, D. & 3 others, Hirase, Hajime, Mori, Yuki & Nedergaard, Maiken, 2020, In: Science. 367, 6483, 8 p., eaaw7462.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

    Oe, Y., Wang, Xiaowen, Patriarchi, T., Konno, A., Ozawa, K., Yahagi, K., Hirai, H., Tian, L., McHugh, T. J. & Hirase, Hajime, 2020, In: Nature Communications. 11, 1, 15 p., 471.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Editorial: Role of Astrocytes in Seizures Induced by Traumatic Brain Injury

    Wang, F., Pan, F., Hirase, Hajime & Huang, J. H., 2020, In: Frontiers in Neurology. 11, 604788.

    Research output: Contribution to journalEditorialResearchpeer-review

  34. 2019
  35. Published

    Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke

    Monai, H., Wang, X., Yahagi, K., Lou, N., Mestre, H., Xu, Q., Abe, Y., Yasui, M., Iwai, Y., Nedergaard, Maiken & Hirase, Hajime, 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 22, p. 11010-11019 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Glycogen distribution in mouse hippocampus

    Hirase, Hajime, Akther, S., Wang, X. & Oe, Y., 2019, In: Journal of Neuroscience Research. 97, 8, p. 923-932 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Pioglitazone reversed the fructose-programmed astrocytic glycolysis and oxidative phosphorylation of female rat offspring

    Wu, C., Hung, C., Hirase, Hajime, Tain, Y., Lee, W., Chan, J. Y. H., Fu, M., Chen, L., Liu, W., Liang, C., Ho, Y., Kung, Y. C., Leu, S. & Wu, K. L. H., 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 4, p. E622-E634

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Regional Distribution of Glycogen in the Mouse Brain Visualized by Immunohistochemistry

    Oe, Y., Akther, S. & Hirase, Hajime, 2019, Brain Glycogen Metabolism. DiNuzzo, M. & Schousboe, A. (eds.). 1 ed. Cham: Springer, Vol. 23. p. 147-168 22 p. (Advances in Neurobiology, Vol. 23).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  39. Published

    Transcranial Direct Current Stimulation (tDCS Induces Adrenergic Receptor-Dependent Microglial Morphological Changes in Mice

    Mishima, T., Nagai, T., Yahagi, K., Akther, S., Oe, Y., Monai, H., Kohsaka, S. & Hirase, Hajime, 2019, In: eNeuro. 6, 5, 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2018
  41. Published

    Aquaporin-4-dependent glymphatic solute transport in the rodent brain

    Mestre, H., Hablitz, L. M., Xavier, A. L. R., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Rivera, R. M. C., Simon, M. J., Pike, M. M., Pla, V., Du, T., Kress, B. T., Wang, X., Plog, B. A., Thrane, A. S., Lundgaard, I., Abe, Y., Yasui, M. & 6 others, Thomas, J. H., Xiao, M., Hirase, Hajime, Asokan, A., Iliff, J. J. & Nedergaard, Maiken, 2018, In: eLife. 7, 31 p., :e40070.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 215672745