All publications for Steven A. Goldman, M.D., Ph.D. and The Goldman Lab
(Updated October 2024)
2024 |
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Goldman, S.A., Franklin, R.J.M., Osorio, M.J. Stem and progenitor cell-based therapy of myelin disorders. Handbook of Clinical Neurology. Federoff, H., Barker, R., eds. 205:283, 295, 2024. |
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Li, C., Huynh, N.P., Schanz, S., Windrem, M.S., Goldman, S.A. JC virus propagation is potentiated by glial replication and accelerated by demyelination-associated glial proliferation. Brain, 2024 Aug 12:awae252. |
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Huynh, N.P.T., Mikhail Osipovitch, M., Foti, R., Vieira, R., Bates, J., Goldman, S.A. Shared dysregulation of glial differentiation underlies disruption of glutamate signaling common to Huntington’s disease and schizophrenia. Brain, 2024 Sep 3;147(9):3099-3112. |
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Rasmussen, M.K., Møllgaard, K., Bork, P., Weikop, P., Esmail, T., Drici, L., Albrechtsen, N.J.W., Carlsen, J.F., Huynh, N., Ghitani, N. ,Mann, M., Goldman, S.A., Mori, Y., Chesler, A., Nedergaard, M. Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model. Science, 385, 80–86, 2024. |
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Mariani, J.N., Mansky, B., Huynh, N., Madsen, P.M., Kesel, E.R., Kuypers, N., Chandler-Militello, D., Benraiss, A., Goldman, S.A. Repression of developmental transcription factor networks triggers age-associated gene expression in human glial progenitor cells. Nature Communications 15:3873-82, 2024. |
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Patel K.S., Tessema K.K., Kawaguchi R., Dudley L., Alvarado A.G., Muthukrishnan S.D., Perryman T., Hagiwara A., Swarup V., Liau L.M., Wang A.C., Yong W., Geschwind D.H., Nakano I., Goldman S.A., Everson R.G., Ellingson B.M., Kornblum H.I. Single-nucleus expression characterization of non-enhancing region of recurrent high-grade glioma. Neuro-oncology Advances 6(1):vdae005, 2024. |
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Franklin, R.J.M., Bodini, B., Goldman, S.A. Remyelination in the Central Nervous System. Cold Spring Harb. Perspect. Biol., 2024 Mar 1;16(3):a041371. |
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Ding F., Sun Q., Long C., Rasmussen R.N., Peng S., Xu Q., Kang N., Song W., Weikop P., Goldman S.A., Nedergaard M. Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration. Brain, 2024, 3;147(5):1726-1739. |
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Zhao, L., Qiu, Z., Yang, Z., Xu, L., Pearce, T.M., Wu, Q., Yang, K., Li, F.,….Goldman, S.A., Taylor, M.D., Zhou, S., Rich, J.N. Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism. Nature Cancer, 2024, Jan;5(1):147-166. |
2023 |
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Hussain R, Tithof J, Wang W, Cheetham-West A, Song W, Peng W, Sigurdsson B, Kim D, Sun Q, Peng S, Plá V, Kelley DH, Hirase H, Castorena-Gonzalez JA, Weikop P, Goldman SA, Davis MJ, Nedergaard M. Potentiating glymphatic drainage abrogates post-traumatic cerebral edema. Nature, 2023, Nov;623(7989):992-1000. |
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Takasugi, M., Ohtani, N.,…. Goldman, S. A., Satoh, J., Ito, S., Seluanov, A., Gorbunova, V. CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance. Cell Reports 2023, 42, 113130. |
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Vieira, R., Mariani, J., Stephensen, H.J.T., Solly, R., Mousaei. M., Sporring, J., Benraiss, A., Goldman, S.A. Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain. Nature Biotechnology, 2023 May;42(5):719-730. |
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Stogsdill J.A., Harwell, C.C., Goldman, S.A. Astrocytes as master modulators of neural networks: Synaptic functions and disease-associated dysfunction of astrocytes. Ann. NY Acad. Sci. 2023, Jul;1525(1):41-60. |
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Villanueva, C.B., Stephensen, H.J.T., Benraiss, A., Mokso, R., Sporring, J., Goldman, S.A. Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington’s disease. Proc. Natl. Acad. Sci. 3;120(24):e2210719120. |
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Khakh, B., Goldman, S.A. Astrocyte contributions to Huntington’s disease pathophysiology. Ann. NY Acad. Sci. 1522:42-59, 2023. |
2022 |
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Osorio, J., Mariani, J., Cornwell, A. Goldman, S.A. Glial progenitor cells of the adult human white and grey matter are contextually distinct. Glia 71:524-540, 2022. |
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Ghochani, Y., Muthukrishnan, S.D.,…Goldman, S.A., Carmichael, S.T., Nakano, I., Coppola, G., Seidlits, S.K., Kornblum, H.I. A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration. Cell Reports 41(3):111511, 2022. |
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Muthukrishnan, S., Kawaguchi, R.,….Goldman, S.A., Geschwind, D.H., Kornblum, H.I. P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells. Nature Communications, 13 (1): 6202, 2022. |
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Wang, X., Delle, C., Asiminas, A.,….Goldman, S.A., Nedergaard, M., Hirase, H. Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation. Cell Reports Methods. 2:100302, 2022. |
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Alvarado AG, Tessema K, Muthukrishnan SD, Sober M, Kawaguchi R, Laks DR, Bhaduri A, Swarup V, Nathanson DA, Geschwind DH, Goldman SA, Kornblum HI. Pathway-based approach reveals differential sensitivity to E2F1 inhibition in glioblastoma.; Cancer research communications; Vol 2(9), pp. 1049-1060. 2022 Sep 22. |
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Benraiss A, Mariani JN, Tate A, Madsen PM, Clark KM, Welle KA, Solly R, Capellano L, Bentley K, Chandler-Militello D, Goldman SA. A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice.; Cell reports; Vol 40(9), pp. 111291. 2022 Aug 30. |
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Rosser AE, Busse ME, Gray WP, Badin RA, Perrier AL, Wheelock V, Cozzi E, Martin UP, Salado-Manzano C, Mills LJ, Drew C, Goldman SA, Canals JM, Thompson LM. Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder.; Brain : a journal of neurology; Vol 145(5). 2022 Jun 03. |
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Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Wang Q, VanderVeer-Harris N, Pham A, Alvarado AG, Condro MC, Gao F, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns TC, Goldman SA, Geschwind DH, Kornblum HI. P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.; Nature communications; Vol 13(1), pp. 6202. 2022 Jan 19. |
2021 |
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Benraiss A, Mariani JN, Osipovitch M, Cornwell A, Windrem MS, Villanueva CB, Chandler-Militello D, Goldman SA, Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease.; Cell reports; Vol 36(1). 2021 Jul 06. |
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Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y, Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes.; Nature communications; Vol 12(1). 2021 Jun 25. |
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Park HJ, Jeon J, Choi J, Kim JY, Kim HS, Huh JY, Goldman SA, Song J, Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model.; Cell proliferation. 2021 Jun 21. |
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Hyun I, Clayton EW, Cong Y, Fujita M, Goldman SA, Hill LR, Monserrat N, Nakauchi H, Pedersen RA, Rooke HM, Takahashi J, Knoblich JA, ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts.; Stem cell reports; Vol 16(6). 2021 Jun 08. |
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Lovell-Badge R, Anthony E, Barker RA, Bubela T, Brivanlou AH, Carpenter M, Charo RA, Clark A, Clayton E, Cong Y, Daley GQ, Fu J, Fujita M, Greenfield A, Goldman SA, Hill L, Hyun I, Isasi R, Kahn J, Kato K, Kim JS, Kimmelman J, Knoblich JA, Mathews D, Montserrat N, Mosher J, Munsie M, Nakauchi H, Naldini L, Naughton G, Niakan K, Ogbogu U, Pedersen R, Rivron N, Rooke H, Rossant J, Round J, Saitou M, Sipp D, Steffann J, Sugarman J, Surani A, Takahashi J, Tang F, Turner L, Zettler PJ, Zhai X ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.; Stem cell reports. 2021 May 25. |
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Kim KP, Li C, Bunina D, Jeong HW, Ghelman J, Yoon J, Shin B, Park H, Han DW, Zaugg JB, Kim J, Kuhlmann T, Adams RH, Noh KM, Goldman SA, Schöler HR, Donor cell memory confers a metastable state of directly converted cells.; Cell stem cell. 2021 Apr 07. |
| Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A- Reactive astrocyte nomenclature, definitions, and future directions.; Nature neuroscience. 2021 Feb 15. |
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Goldman SA,Mariani JN, Madsen PM Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic.; Seminars in cell & developmental biology. 2021 Jan 04. |
2020 |
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Nedergaard M, Goldman SA Glymphatic failure as a final common pathway to dementia.; Science (New York, N.Y.); Vol 370(6512). 2020 Oct 02. |
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Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen JF, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q, The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis.; Cell stem cell. 2020 Aug 04 |
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Goldman SAGlial evolution as a determinant of human behavior and its disorders.; Annals of the New York Academy of Sciences; Vol 1471(1). 2020 Jul. |
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Windrem MS, Schanz SJ, Zou L, Chandler-Militello D, Kuypers NJ, Nedergaard M, Lu Y, Mariani JN, Goldman SAHuman Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.; Cell reports; Vol 31(7). 2020 May 19 |
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Nolbrant S, Giacomoni J, Hoban DB, Bruzelius A, Birtele M, Chandler-Militello D, Pereira M, Ottosson DR, Goldman SA,Parmar M Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons.; Stem cell reports; Vol 15(4). 2020 Jan 13. |
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Dietz AG, Goldman SA, Nedergaard M. (2020) Glial cells in schizophrenia: a unified hypothesis. Lancet Psychiatry. 7, 3, p. 272-281. |
2019 |
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Osipovitch, M., Asenjo-Martinez, A., Mariani, J., Cornwell, A., Dhaliwal, S., Zou, L., Chandler-Militello, D., Wang, S., Li, X., Benraiss, S., Agate, R., Lampp, A., Benraiss, A, Windrem, M, Goldman, S.A. (2019) Human ESC-derived chimeric mouse models of Huntington’s Disease reveal cell-intrinsic defects in glial progenitor cell differentiation. Cell Stem Cell 24:107-122, 2019. PMID: 30554964. |
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Mariani, J., Zou, L., Goldman, S.A. Human glial chimeric mice define the role of glial pathology in human disease. In: D. Lyons, ed. Oligodendrocytes. Meth. Molec. Biol. 1936:311-331, 2019. PMID: 30820907. |
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Liu, Z., Osipovitch, M., Benraiss, A., Huynh, N.P.T., Foti, R., Bates, J., Chandler-Militello, D., Findling, R.L., Tesar, P., Nedergaard, M., Windrem, M., Goldman, S.A. Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling. Cell Reports 27:3832-3843, 2019. PMID: 31242417. |
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Wang, M., Qin, C., Luo, X.,…Goldman, S.A., Nedergaard, M., Wang, W. Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease. Theranostics 9:4474-4493, 2019. PMID: 31285774. |
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Nobuta, H., Yang, N.,…Goldman, S.A., Kriegstein, A.R., Franklin, R.J.M., Rowitch, D.H., Wernig, M. Oligodendrocyte death in Pelizaeus-Merzbacher disease is rescued by iron chelation. Cell Stem Cell 25:531-541, 2019. PMID: 31585094. |
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Osorio, M. J., Lassen, Mette, Kristine, M. & Goldman, Steven Alan. The intrinsic effects of EIF2B mutations in human Vanishing White Matter-derived glial progenitor cells. Glia. 67, S1, p. E312-E313 2 p., T08-031A, 2019. |
2018 |
| Barker, R.A., Carpenter, M.K., Forbes, S., Goldman, S.A., Jamieson, C., Murry, C.E., Takahashi, J., Weir, G. The challenges of first-in-human stem cell clinical trials: What does his mean for ethics and institutional review boards? Stem Cell Reports. 10:1429-1431, 2018. |
| Goldman, S. Transplanted neural progenitors bridge gaps to benefit cord-injured monkeys. Nature medicine 24:388-390, 2018. PMID: 29634690 |
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Osorio, J., Goldman, S.A. Neurogenetics of Pelizaeus-Merzbacher disease. Handbook of clinical neurology: 148:701-722, 2018. PMID: 29478609 2017 |
| Goldman, S.A. Patience pays in spinal repair. J. Clinical Invest. 127:3284-6. doi: 10.1172/JCI96650, 2017. PMID: 28825601 |
| Windrem, M., Osipovitch., Wang, S., Bates, J., Zou, L., Liu, Z., Schanz, S., Munir, J., Chandler-Militello, D., Miller, R., Nedergaard, M., Findling, R., Tesar, P.J., Goldman, S.A. Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia. Cell stem cell, 21:195-208. doi: 10.1016/j.stem.2017.06.012, 2017. PMID: 28736215 |
| Sun, W., Cornwell A., Li, J., Peng, S., Osorio, M.J., Aalling, N., Wang, S., Benraiss, A., Lou, N., Goldman, S.A., Nedergaard, M. SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions. J. Neuroscience 37:4493-4507, 2017. doi: 10.1523/jneurosci. 3199-16. PMID: 28336567. |
| Khakh, B., Beaumont, V., Munoz-Sanjuan, I., Goldman, S.A., Grantyn, R. Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease. Trends in Neuroscience 40:422-437, 2017. doi: 10.1016/j.tins. 2017.05.002. PMID: 28578789. |
| Nevin, Z.S., Factor, D.C., Karl R.T., Douvaras, P., Laukka, J., Windrem, M.S., Goldman, S.A., Fossati, V., Hobson, G.M., Tesar, P.J. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes. Am. J. Hum. Genet. 100:617-634. doi: 10.1016/j.ajhg. 2017.03.005, 2017. PMID: 28366443. |
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Osorio MJ, Rowitch DH, Tesar P, Wernig M, Windrem MS, Goldman SA Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease.; Stem cells (Dayton, Ohio); Vol 35(2). 2017 Feb. |
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Goldman, S.A. Progenitor cell-based treatment of glial disease.. Prog. Brain. Res. 231:165-189, doi: 10.1016/bs.pbr. 2017.02.010. 2017. PMID: 28554396. 2016 |
| Osorio, J., Goldman, S.A. Glial progenitor cell-based treatment of the childhood leukodystrophies.Exp. Neurol. 283:476-488. 10.1016/j.expneurol.2016.05.010, 2016. PMID: 27170209 |
| Wang, Y., Zhao, Z., Rege, S.V., Wang, M., Si, G, Zhou, Y., Wang, S., Griffin, J.H., Goldman, S.A., Zlokovic, B.V. 3K3A-activated protein C stimulates post-ischemic neuronal repair by human neural stem cells in mice. Nature medicine 2016 Sep;22(9):1050-5. doi: 10.1038/nm.4154, 2016. PMID: 27548576. |
| Osorio MJ, Rowitch DH, Tesar P, Wernig M, Windrem MS, Goldman SA. Stem cell-based treatment of Pelizaeus-Merzbacher Disease. Stem Cells 35:311-315, 2016. doi: 10.1002/stem.2530, 2016. PMID: 27882623. |
| Liang, Q., Luo, Z., Zeng, J., Chen, W., Foo, S.-S., Lee, S.-A., Ge, J., Wang, S., Goldman, S.A., Zlokovic, B., Zhao, Z., Jung, J.U. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell stem cell. 19:663-71, 2016. PMID: 27524440 |
| *Benraiss, A., Wang, S., Herrlinger, S., Li, X., Chandler-Militello, D., Mauceri, J., Toner, M., Lundgaard, I., Xu, Q., Ding, F., Wang, F., Kang, N., Kang, J., Curtin, P., Brunner, D., Windrem, M., Munoz-Sanjuan, I., Nedergaard, M., Goldman, S.A. Human glia can both induce and rescue aspects of phenotype in Huntington Disease. Nature Commun., 7:11758, doi: 10.1038/ncomms11758, 2016. PMID: 27273432 |
| Nedergaard, M., Goldman, S.A. The glymphatic system of the brain. Scientific American 314:44-49, March, 2016. PMID: 27066643 |
| Zhao, C., Deng, Y.,… van Es, J., Xin, M., Parry, L., Goldman, S.A., Clevers, H., Lu, Q.-R., Yu, K., Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature Commun. 7:10883, doi: 10.1038, 2016. PMID: 26955760 |
| Zhang, L., He, X., Liu, L., Jiang, M., Zhao, C.,…Lazar, M., Goldman, S.A., Olson, E.N., Lu, Q. R. Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Developmental cell 36:316-330, 2016. PMID: 26859354 |
| Goldman, S.A. Stem cell therapeutics for neurological disease: Facts, fantasies, and wishful thinking. Cell stem cell, 18:174-188, 2016. PMID: 26849304 |
| Osorio, J. Goldman, S.A. Cell therapeutics for disorders of glia. In: Translational Neuroscience. M. Tuszynski, ed. Chapter 15: p. 275-96. Springer, 2016. |
| Lou, N., Takano, T., Pei, Y., Xavier, A., Goldman, S.A., Nedergaard, M. P2RY12-dependent microglial closure of the injured blood-brain barrier. Proc. Natl. Acad. Sci. 113:1074-9, 2016. PMID: 26755608 |
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Auvergne, R., Wu, C., Benraiss, A., Connell, A., Au, S., Cornwell, A., Osipovitch, M., Hugo Guerrero-Cazares, Quinones-Hinojosa, A., Goldman, S.A. PAR1 inhibition suppresses A2B5-defined glioma-initiating cells and their derived gliomas. Oncogene 35: 3817-28, 2016. PMID: 26616854 2015 |
| Goldman, S.A., Kuypers, N.J. How to make an oligodendrocyte. Development 142:3983-95, 2015. PMID: 26628089 |
| Illiff, J., Goldman, S.A., Nedergaard, M. Implications of the discovery of brain lymphatics. Lancet Neurology 14:997-9, 2015. PMID: 26376966 |
| Xavier, A.L.R., Kress, B., Goldman, S.A., de Menezes, J. R., Nedergaard, M. A distinct population of microglia supports adult neurogenesis in the subventricular zone. J. Neuroscience 35:11848-61, 2015. |
| Goldman, S.A., Nedergaard, M., Windrem, M. Human glial chimeric mouse models of neurological disease. Glia, 63(8):1483-93, 2015. |
| Helman, G., Van der Knaap, M.S., Back, S.A., Damiani, S., Goldman, S.A., Petryniak, M., Rowitch, D., Messing, A., Wrabetz, L., Schiffmann, R., Eichler, F., Escolar, M.L., Vanderver, A. Disease-specific therapies in leukodystrophies and leukoencephalopathies. Molec. Genetics Metab. 114:527-536, 2015. |
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Franklin, R.J.M., Goldman, S.A. Glial Disease and Repair: Remyelination. Cold Spring Harbor Perspect. Biol. 7:a020594. In: Glia. B. Barres, M. Freedman, Stevens, B., eds. Cold Spring Harbor Press, 2015. 2014 |
| Windrem, M., Schanz, S., Morrow, C., Munir, J., Chandler-Militello, D., Wang, S., Goldman, S.A. A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia. Journal of Neuroscience. 34:16153-61, 2014. |
| Kondo, Y., Windrem, M., Zou, L., Chandler-Militello, D., Schanz, S., Auvergne, R., Betstadt, S., Harrington, A., Johnson, M., Kazarov, A., Gorelik, L., Goldman, S.A. JC virus-infected human glial chimeric mice reveal progressive multifocal leukoencephalopathy to be an astrocytic disease. J. Clin. Invest., 124:5323-36, 2014 (cover; featured story, JCI Impact). |
| Autelitano, F., Loyaux, D.,…Wang, S., Auvergne, R., Badarinarayana, V., Smith, M., Guillemot, J., Goldman, S.A., Natesan, S., Ferrara, P., August, P. Identification of novel tumor-associated cell surface sialoglycoproteins in human glioblastoma tumors using quantitative proteomics. PloS one 9:e110316, 2014. PMID: 25360666 |
| Xavier,A.L., Menezes, J.R., Goldman, S.A., Nedergaard M. Fine-tuning the central nervous system: microglial modeling of cells and synapses. Phil. Trans. Royal Soc. B 369 (1654), 2014. |
| Fox, I., Daley, G., Goldman, S.A., Huard, J., Kamp, T., Trucco, M. Pluripotential stem cells as therapy. Science 345:889-898, 2014. |
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Goldman, S.A., Osorio, J. So many progenitors, so little myelin. Nature neuroscience, 17(4):483-5, 2014. PMID: 24671061 2013 |
| Auvergne, R., Sim, F., Wang, S., Chandler-Militello, D., Burch, J., Al-Fanek, Y., Davis, D., Benraiss, A., Walter, K., Achanta, P., Johnson, M., Quinones-Hinojosa, A., Natesan, S., Ford, H., Goldman, S.A. Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes.Cell reports 3(6):2127-41, 2013. PMID: 23727239 |
| Benraiss, A., Toner, M., Xu, Q., Bruel-Jungerman, E., Rogers, E.H., Wang, F., Economides, A.N., Davidson, B.L., Kageyama, R., Nedergaard, M., Goldman, S.A. Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington’s disease, Cell stem cell 12(6):787-99, 2013. PMCID: PMC4051319 |
| Goldman, S.A. White matter from fibroblasts. Nature biotechnology 31(5):412-3, 2013. PMID: 23657393 |
| Guo, H, Zhao, Z, Yang, Q, Wang, M, Bell, R.D., Wang, S, Chow, N, Davis, T.P., Griffin, J.H., Goldman, S.A., Zlokovic, B.V. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J. Neuroscience 33(14):6181-90, 2013. PMCID: PMC3707621 |
| *Han, X., Chen, M., Wang, F., Windrem, M., Wang, S., Shanz, S., Xu, Q., Oberheim, N., Bekar, L., Betstadt, S., Silva, A., Takano, T., Goldman, S.A., Nedergaard, M. Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell stem cell 12(3):342-53, 2013. PMCID: PMC3700554 |
| Goldman, S.A., Chen, Z., Ye, R., Testosterone modulated angiogenesis and neurogenesis in the adult songbird brain. Neuroscience 239:139-48, 2013. PMID: 23291451 |
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*Wang, S., Bates, J., Li, X., Schanz, S., Chandler-Militello, D., Levine, C., Maherali, N., Studer, L., Hochedlinger, K., Windrem, M.S., Goldman, S.A. Human iPS cell-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination, Cell stem cell 12(2):252-64, 2013. PMCID: PMC3700553 2012 |
| Sim, F., Goldman, S.A. Gene expression patterns of oligodendrocyte progenitor cells and oligodendroglia. In: Neuroglia, 3d ed., H. Kettenmann and B. Ransom, Eds. Chapter 29, pp. 358-373. Oxford Univ. Press, 2012. |
| Goldman, S.A., Nedergaard, M., Windrem, M. Glial progenitor cell-based treatment and modeling of neurological disease. Science 338(6106):491-5, 2012. PMCID: PMC3548656 |
| McClain, C., Sim, F., Goldman, S.A. Pleiotrophin suppression of receptor tyrosine phosphatas maintains the self-renewal competence of fetal human oligodendrocyte progenitors. J. Neuroscience 32(43):15066-75, 2012. PMCID: PMC3700539 |
| Iliff, J., Wang, M., Liao, Y., Plogg, B., Peng, W., Benveniste, H., Vates, G. E., Deane, R., Goldman, S.A., Nagelhus, E., Nedergaard, M. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Science Transl. Med. 4(147):147ra111, 2012. PMCID: PMC3551275. PMID: 22896675. |
| Benraiss, A., Bruel-Jungerman, E., Lu, G., Economides, A.N., Davidson, B., Goldman, S.A. Sustained induction of neuronal recruitment to the adult rat striatum by AAV4-delivered noggin and BDNF. Gene therapy 19(5):483-93, 2012. PMCID: PMC3655807 |
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Oberheim, N., Goldman, S.A., Nedergaard, M. Heterogeneity of Astrocytic Form and Function. Methods Mol. Biol. 814:23-45, 2012. PMCID: PMC3506190 2011 |
| Goldman, S.A., Chen, Z. Perivascular instruction of cell genesis and fate in the adult brain. Nature neuroscience 14(11):1382-9, 2011. PMCID: PMC3655803 |
| *Sim, F., McClain, C., Schanz, S.J., Protack, T.L., Windrem, M., Goldman, S.A. CD140a identifies a population of highly myelinogenic, migration-competent, and efficiently engrafting human oligodendrocyte progenitor cells. Nature biotechnology, 29 (10):934-41, 2011. PMCID: PMC3365580 |
| Benraiss, A., Goldman, S.A. Cell therapy and induced neuronal replacement for Huntington’s Disease. Neurotherapeutics 8(4):577-90, 2011. PMCID: PMC3250300 |
| Eyler, C.E., Wu Q., Yan K., MacSwords J.M., Chandler-Militello D., Misuraca K.L., Lathia J.D., Forrester M.T, Lee J., Stamler J.S., Goldman S.A., Bredel M., McLendon R.E., Sloan A.E., Hjelmeland A.B., Rich J.N. Glioma Stem Cell Proliferation and Tumor Growth are Promoted by Nitric Oxide Synthase-2. Cell 146(1):53-66, 2011. PMCID: PMC3144745 |
| Bugiani, M., Boor, I., van Kollenburg, B., Postma, N., Polder, E., van Berkel, C., van Kesteren, R., Windrem, M., Hol, E., Scheper, G., Goldman, S.A., van der Knaap, M.S. Defective glial maturation in vanishing white matter disease. J. Neuropath. Exp. Neurol. 70(1):69-82, 2011. PMID: 21157376 |
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Goldman, S.A. Progenitor cell-based treatment of the pediatric myelin disorders. Arch. Neurology, 68(7):848-56, 2011. PMCID: PMC3358919 2010 |
| Persson, A., Petritsch, C., Swartling, F., Itsara, M., Sim, F., Auvergne, R., Goldenbergm D.D., Vandenberg, S.R., Nguyen, K.N., Yakovenko, S., Ayers-Ringler, J., Nshiyama, A., Stallcup, W.B., Berger, M.S., Bergers, G., McKnight, T., Goldman, S.A., Weiss, W. Non-stem cell origin for oligodendroglioma. Cancer cell 18(6):669-82, 2010. PMCID: PMC3031116 |
| Wang, S., Chandler, D., Lu, G., Roy, N.S., Zielke, A., Auvergne, R., Stanwood, N., Geschwind, D., Coppola, G., Nicolis, S., Sim, F., Goldman, S.A. Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting. J. Neuroscience 30(44):14635-48, 2010. PMCID: PMC3358973 |
| Zhang, S., Li, B., Lovatt, D., Xu, J., Song, D., Goldman, S.A., Nedergaard, M., Hertz, L., Peng, L. 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'. Neuron Glia Biol. 6(2):113-25, 2010. PMID: 20846463 |
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Hertz, L., Lovatt, D., Goldman, S.A. Nedergaard, M. Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i. Neurochem. Int. 57(4):411-20, 2010. PMCID: PMC2934885 2009 |
| Hartog, T.E., Dittrich, F., Pieneman, A., Jansen, R., Frankl-Vilches, C., Lessmann, V., Lilliehook, C., Goldman, S.A., Gahr, M. Brain-Derived Neurotrophic Factor Signaling in the HVC Is Required for Testosterone-Induced Song of Female Canaries. J. Neuroscience, 29(49):15511-9, 2009. PMCID: PMC3377376 |
| Sim, F., Windrem, M., Goldman, S. Fate determination of adult human glial progenitor cells. Neuron glia biology 5(3-4):45-55, 2009. PMID:19807941 |
| Peng, W., Cotrina, M., Han, X., Yu, H., Bekar, L., Blum, L., Takano, T., Tian, G., Goldman, S., Nedergaard, M. Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc. Natl. Acad. Sci. 106(30): 12489-93, 2009. PMCID: PMC2718350 |
| Karumbayaram, S., Novitch, B., Patterson, M., Umbach, J., Richter, L., Lindgren, A., Conway, A., Clark, A., Goldman, S., Plath, K., Wiedau-Pazos, M., Kornblum, H., Lowry, W. Directed differentiation of human induced pluripotent stem cells (iPS) generates active motor neurons. Stem Cells 27(4):806-11, 2009. PMCID: PMC2895909 |
| Oberheim, N., Takano, T., Han, X., He, W., Lin, J., Wang, F., Xu, Q., Wyatt, J., Pilcher. W., Ojemann, J., Ransom, B., Goldman, S., Nedergaard, M. Uniquely hominid features of adult human astrocytes. J. Neuroscience 29(10):3276-87, 2009. PMCID: PMC2819812 |
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Karumbayaram, S., Kelly, T., Paucar, A.,…Charles, A., Goldman, S., Kornblum, H., Wiedau-Pazos, M. Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS. Dis. Model Mech. 2(3-4):189-95, 2009. PMCID: PMC2650191 2008 |
| Ben-Hur, T., Goldman, S. Prospects of cell therapy for disorders of myelin.tion. Ann. NY Acad. Sci. 1142:218-49, 2008. PMID: 18990129 |
| Goldman, S., Natesan, S. A niche-defying feat: induced oligoneogenesis in the adult dentate gyrus. Cell stem cell 3:125-6, 2008. PMID: 18682232. |
| Goldman, S. From canaries to the clinic. Regenerative medicine 3:655-659, 2008. PMID: 18729789. |
| Goldman, S., Schanz, S., Windrem, M. Stem cell-based strategies for treating pediatric disorders of myelin.Human molecular genetics 17:R76-83, 2008. PMID: 18632701. |
| * Windrem, M., Schanz, S., Guo, M., Tian, G.-F., Washco, V., Moyle, C., Stanwood, N., Rasband, M., Roy, N.S., Nedergaard, M., Havton, L., Wang, S., Goldman, S. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell 2: 553–65, 2008. PMCID:PMC3358921 |
| Sim, F., Lang, J., Compton, T., Guo, M., Wang, S., Roy, N., Schwartz, T., Pilcher, W., Goldman, S. Statin treatment of adult human Glial progenitors induces PPAR-mediated oligodendrocytic differentiation. Glia 56:954-962, 2008. PMID: 18383345. |
| Duncan, I., Goldman, S., Macklin, W., Rao, M., Weiner, L., Reingold, S. Stem cell therapy in multiple sclerosis: promise and controversy. Multiple Sclerosis 14:541-6, 2008. PMID: 18562508. |
| Kim, D.-H., Lilliehook, C., Roides, B., Chang, M., Mobashery, S., Goldman, S. Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain. J. Neuroscience 28:208-216, 2008. PMID: 18171938. |
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Goldman, S. Neurogenesis in the adult songbird: A model for inducible striatal neuronal addition. In: Adult neurogenesis. F. Gage, G. Kempermann, eds. Cold Spring Harbor Press, 2008, pp. 593-618. 2007 |
| Roy, N. S., Chandler-Militello, D., Lu, G., Wang, S., Goldman, S. Retrovirally-mediated telomerase immortalization of human neural progenitor cells. Nature protocols, 2:2815-2825, 2007. PMID: 18007617. |
| Lovatt, D., Sonnewald, U., Schousboe, A., He, W., Lin, J., Han, X., Takano, T., Sim, F., Wang, S., Goldman, S., Nedergaard, M. The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J. Neuroscience 27:12255-66, 2007. PMID: 17989291. |
| Shin, S., Sun, Y., Liu, Y., .....Stice, S., Smith, A., Goldman, S., Reubinoff, B., Zhan, M., Rao, M., Chestnut, J. Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue. Stem Cells 25:1298-1306, 2007. PMID: 17272497. |
| Cho, S. R., Benraiss, A., Chmielniecki, E., Samdani, A., Economides, A, Goldman, S. Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington's Disease. J. Clin. Invest., 117: 2889-2902, 2007. PMCID: PMC1978427. |
| Goldman, S. Disease targets and strategies for the therapeutic modulation of endogenous neural stem and progenitor cells. Clinical Pharm. Ther. (Nature Pub.), 82: 453-460, 2007. PMID: 17713467. |
| Ballabh, P., Xu, H., Hu, F., Braun, A., Smith, K., Ungvari, Z., Goldman, S., Csiszar, A. Nedergaard, M. Angiogenic inhibition reduces germinal matrix hemorrhage. Nature medicine, 13:477-485, 2007 (cover photo). PMID: 17401377. |
| Lin, J., Takano, T., Goldman, S., Nedergaard, M. Purinergic signaling regulates neural progenitor cell expansion and neurogenesis. Dev. Biol. 302:356-366, 2007. PMCID: PMC1924912. |
| Keyoung, H., Goldman, S. Glial progenitor-based repair of demyelinating neurological diseases. Neurosurg. Clin. N.A., 18:93-104, 2007. PMID: 17244557. |
| Goldman, S., Roy, N. S. Beal, M. F., Cleren, C. Large stem cell grafts could lead to erroneous interpretations of behavioral results?? Nature medicine 13:118-119, 2007 (correspondence). PMID: 17290261 |
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Kanai, R., Tomita, H., Hirose, Y., Ohba, S., Goldman, S., Okano, H., Kawase, T., Yazaki, T. Augmented therapeutic efficacy of an oncolytic HSV1 mutant expressing ICP34.5 under the transcriptional control of musashi1 promoter in the treatment of malignant glioma. Human gene therapy 18:63-73, 2007. PMID: 17238803. 2006 |
| Lilliehook, C., Goldman, S. Microvascular influences on progenitor cell mobilization and fate in the adult brain. In: Blood-Brain Barriers, vol. 1. Dermietzel, R., Spray, D., Nedergaard, M., eds. Wiley-VCH. Weinheim, 2006, pp. 61-74. |
| Sim, F., Keyoung, H., Goldman, J.E., Roy, N., Goldman, S. Neurocytoma is a tumor of adult neuronal progenitor cells. J. Neuroscience 26:12544-12555, 2006. PMID: 17135416. |
| Roy, N.S., Cleren, C., Singh, S., Beal, F., Goldman, S. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nature medicine 12:1259-1268, 2006 (cover photo). PMID: 17057709. |
| Oberheim, N., Wang, X., Goldman, S., Nedergaard, M. Astrocytic complexity distinguishes the human brain. Trends in Neuroscience. 29:1-7, 2006. PMID: 16938356. |
| Goldman, S., Windrem, M. Cell replacement therapy in neurological disease. Phil. Trans. Royal. Soc. B. 361:1463-75, 2006. PMCID: PMC1664668. |
| Goldman, S.A., Lang, J., Roy, N.S., Schanz, S.J., Sim, F.J., Wang, S., Washco, V., Windrem, M.S. Progenitor cell-based myelination as a model for cell-based therapy of the central nervous system. In: Stem Cells in Reproduction and the Brain. Ernst Schering Res Found Workshop. 60:195-213, 2006. PMID: 16903424. |
| Sim, F., Lang, J., Waldau, B., Roy, N., Schwartz, T., Pilcher, W., Chandross, K., Natesan, S., Merrill, J., Goldman, S. Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Ann. Neurology 59:763-79, 2006. PMID: 16634042. |
| Goldman, S., Sim, F. Targeted induction of endogenous neural stem and progenitor cells: A new strategy for gene therapy of neurological disease. In: Gene Therapy of the Nervous System: From Bench to Bedside. Kaplitt, M., During, M., eds. Elsevier: San Diego, 2006, pp. 53-65. |
| Kanai, R., Eguchi, K., Takahashi, M., Goldman, S., Okano, H., Kawase, T., Yazaki, T. J. Enhanced therapeutic efficacy of oncolytic herpes vector G207 against human small cell lung cancer: Expression of an RNA-binding protein, Musashi1, as a marker for tailored gene therapy. Gene Medicine 8:1329-1340, 2006. |
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Kanai, R., Tomita, H., Shinoda, A., Takahashi, M., Goldman, S., Okano, H., Kawase, T., Yazaki, T. Enhanced therapeutic efficacy of G207 for the treatment of glioma through Musashi1 promoter retargeting of gamma34.5-mediated virulence. Gene therapy 13:106-16, 2006. PMID: 16163378. 2005 |
| Roy, N.S., Nakano, T., Kang, J., Nedergaard, M., Goldman, S. Enhancer-specific GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp. Neurol. 196:224-234, 2005. PMID: 16198339. |
| Chmielnicki, E., Goldman, S. Stem cells and cell-based therapy in neurodegenerative disease. In: Neuro-degenerative Diseases. F. Beal, A. Lang, A. Ludolph, eds. Cambridge Press. 2005, p. 347-362. |
| Nakano, T., Windrem, M., Zappavigna, V., Goldman, S. Identification of a conserved 125 base-pair Hb9 enhancer that specifies gene expression to spinal motor neurons. Dev. Biology 283: 474-485, 2005. PMID: 15913596. |
| Sim, F., Goldman, S. White matter progenitor cells reside in an oligodendrogenic niche. In: Opportunities and Challenges of Therapies Targeting CNS Regeneration. D. Perez, B. Mitrovic, A. Baron van Evercooren, eds. Ernst Schering Research Foundation/Springer: Berlin, 2005, pp. 61-82. PMID: 16315609. |
| Greene, M., Schill, K. ...Goldman, S., Greely, H, Martin, L, Miller, E, Siegel, A., Solter, D., Gearhart, J., McKhann, G., Faden, R. Moral issues of human to non-human primate neural grafting. Science, 309: 385-386, 2005. PMID: 16020716. |
| Goldman, S. Stem and progenitor cell-based therapy of the human CNS. Nature Biotechnol., 23:862-871, 2005. PMID: 16003375 |
| Goldman, S., Sim, F. Neural progenitor cells of the adult brain. In: Stem Cells: Nuclear programming and therapeutic applications. Novartis Foundation Symposia, vol. 265. John Wiley, London, 2005, 66-92. PMID: 16050251. |
| Goldman, S. Position on stem cell research (reply to editorial comments) Neurology 65:1512-3, 2005. |
| Goldman, S. Neurology and the stem cell debate.(editorial) Neurology 64:1675-76, 2005. PMID: 15911788. |
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Goldman, S. A strong root for stem cells. Nature Cell Biol. 7:341, 2005 2004Goldman, S. Directed mobilization of endogenous neural progenitor cells: the intersection of stem cell biology and gene therapy. Curr. Opin. Molecular Ther. 6:466-472, 2004. PMID: 15537047. |
| Wang, X., Arcuino, G., Takano, T., Lin, J., Peng, W…, Wan, P., Li, P., Xu, Q., Liu, Q.S., Goldman, S., Nedergaard, M. P2X7 receptor inhibition improves recovery after spinal cord injury. Nature medicine, 10:821-7, 2004 (cover photo). PMID: 15258577. |
| Goldman, S. Neural progenitor cells of the adult human forebrain. In: Stem Cells and CNS Development. 2d ed. M. Rao, ed. Humana, Press: New York, 2005. |
| Goldman, S. Cellular plasticity of the adult human brain. In: From Neuroscience to Neurology: neuroscience, molecular medicine, and the therapeutic transformation of neurology, S. Waxman, ed. Amsterdam: Elsevier, 2005, pages 371-382. |
| Chmielnicki, E., Benraiss, A., Economides, A., Goldman, S. Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce the new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone. J. Neuroscience 24:2133-2142, 2004. PMID: 14999064. |
| Goldman, S. A brand-new bird (book review). J. Clin. Invest. 113:495, 2004. PMCID: PMC338274. |
| Roy, N.S., Nakano, T., Keyoung, H., Rashbaum, W., Carpenter, M., Kang, J., Nedergaard, M., Goldman, S. Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nature Biotechnol. 22:297-305, 2004. PMID: 14990951. |
| Windrem, M., Nunes, M., Rashbaum, W., Schwartz, T., Goodman, R., McKhann, G., Roy, N., Goldman, S. Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain. Nature medicine 10:93-97, 2004. PMID: 14702638. |
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Roy, N., Windrem, M., Goldman, S. A. Progenitor cells of the adult human subcortical white matter In: Myelin Biology and Disorders, vol. 1. R. Lazzarini, ed. Elsevier: Amsterdam, 2004, pp. 259-287. 2003 |
| Goldman, S. Glia as neural progenitor cells. Trends in neurosciences. 26: 590-96, 2003. PMID: 14585598. |
| Packer, M., Benraiss, A., Chmielnicki, E., Grinberg, A., Westphal, H., Goldman, S., Enikolopov, G. Nitric oxide negatively regulates mammalian adult neurogenesis. Proc. Natl. Acad. Sci. 100: 9566-71, 2003. PMCID: PMC170958. |
| Nedergaard, M., Ransom, B., Goldman, S. New roles for astrocytes: redefining the functional architecture of the brain. Trends in neurosciences 26: 523-529, 2003. PMID: 14522144. |
| Nunes, M., Roy, N., Keyoung, H., Goodman, R., McKhann, G., Li, J., Nedergaard, M., Goldman, S. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nature medicine 9:239-247, 2003 (cover photo). PMID: 12627226. |
| Windrem, M., Roy, N., Wang, J., Goodman, R., McKhann, G., Goldman, S. Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the adult rat brain. J. Neurosci. Res. 69: 966-975, 2002 (cover photo). PMID: 12205690. |
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* Windrem, M., Roy, N., Nunes, M., Goldman, S. Identification, selection and use of adult human oligodendrocyte progenitor cells. In: Neural Stem Cells for Brain Repair. T. Zigova, E. Snyder, P. Sanberg, eds. Humana: NY, 2003, p. 69-88. 2002 |
| Chmielnicki, E., Goldman, S. Induced neurogenesis by endogenous progenitor cells in the adult mammalian brain. Prog. Brain. Res. 18: 2002. PMID: 12432784. |
| Goldman, S., Chmielnicki, E., Keyoung, H., Nunes, M., Roy, N., Windrem, M. Isolation and induction of adult neural progenitor cells. Clin. Neurosci. 2:70-79, 2002. |
| Goldman, S., Nedergaard, M. Erythropoietin strikes a new cord. Nature medicine 8:11-13, 2002. PMID: 12152030. |
| Louissaint, A., Rao, S., Leventhal, C., Goldman, S. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron 34:945-960, 2002 (featured article; see editorial: Neuron 34:856-58). PMID: 12086642. |
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Lin, J., Takano, T., Cotrina, M., Arcuino, G., Fried, V., Liu, S., Jiang, L., Lichtenberg, H, Haubrich, S., Willecke, K., Goldman, S., Nedergaard, M. Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells. J. Neuroscience 22:4302-4311, 2002. PMID: 12040035. 2001 |
| Keyoung, H., Roy, N., Louissant, A., Benraiss, A., Rashbaum, W., Okano, H., Goldman, S. High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain. Nature Biotechnol. 19:843-50, 2001. PMID: 11533643. |
| Benraiss, A., Chmielnicki, E., Lerner, K., Roh, D., Goldman, S. Adenoviral BDNF induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain. J. Neuroscience, 21: 6718-31, 2001. PMID: 11517261. |
| Sawamoto, K., Atsuyo Yamamoto, A., Kawaguchi, A., Yamaguchi, M., Mori, K., Goldman, S., Okano, H. Direct isolation of neuronal progenitor cells from transgenic mice co-expressing spectrally-distinct fluorescent proteins regulated by stage-specific neural promoters. J. Neurosci. Res. 65:220-227, 2001. PMID: 11494356. |
| Piper, D., Mujtaba, T., Keyoung, H., Roy, N., Goldman, S., Rao, M., Lucero, M. Identification and characterization of neuronal precursors and their progeny from human fetal tissue. J. Neurosci. Res. 66: 356-368, 2001. PMID: 11746353. |
| Sawamoto, K., Nakao, N., Kakishita, K., Ogawa, Y., Toyama, Y., Yamamoto, A., Yamaguchi, M., Mori, K., Itakura, T., Goldman, S., Okano, H. Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene. J. Neuroscience 21:3895-3903, 2001. PMID: 11356877. |
| Kawaguchi, A., Miyata, T., Sawamoto, K., Takashita, N., Akamatsu, W., Okabe, M., Tano, Y., Goldman, S., Okano, H. Nestin-EGFP transgenic mice: visualization of the self-renewal and multipotency of CNS stem cells. Molec. Cell. Neurosci. 17: 259-273, 2001. PMID: 11178865. |
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Goldman, S. Neural progenitor cells of the adult human forebrain. In: Stem Cells and CNS Development. M. Rao, ed. Humana, Press: New York, 2001, pp. 177-206. 2000 |
| Okano, H., Goldman, S. Identification and selection of neural progenitor cells. Neuroscience News 3: 27-31, 2000. |
| Goldman, S., Roy, N. Reply to "Human neural progenitor cells: better blue than green?" (comment) Nature medicine 6: 483-84, 2000. PMID: 10802678 |
| Roy, N., Wang, S., Jiang, L., Kang, J., Benraiss, A., Restelli, C., Fraser, R., Couldwell, W., Kawaguchi, A., Okano, H., Nedergaard, M., Goldman, S. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nature medicine 6: 271-277, 2000 (cover photo). PMID: 10700228. |
| Wang, S., Roy, N., Benraiss, A., Goldman, S. Promoter-based isolation and fluorescence-activated sorting of mitotic neuronal progenitor cells from the adult mammalian ependymal/subependymal zone. Dev. Neurosci. 22:167-176, 2000. PMID: 10657708. |
| Roy, N., Benraiss, A., Wang, S., Fraser, R., Goodman, R., Couldwell, W., Nedergaard, M., Kawaguchi, A., Okano, H., Goldman, S. Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone. J. Neurosci. Res. 59: 321-331, 2000. PMID: 10679767. |
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Grafstein, B., Liu, S., Cotrina, M., Goldman, S., Nedergaard, M. Meningeal cells can communicate with astrocytes by calcium signaling. Annals Neurol. 47: 18-25, 2000. PMID: 10632097. 1999 |
| Roy, N., Wang, S., Harrison-Restelli, C., Benraiss, A., Fraser, R., Gravel, M., Braun, M., Goldman, S. Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter. J. Neuroscience 19:9986-9995, 1999. PMID: 10559406. |
| Simard, M., Couldwell, W., Zhang, W., Cotrina, M., Goldman, S., Nedergaard, M. Glucocorticoids-potent modulators of astrocytic calcium signaling. Glia 28:1-2, 1999 (cover photo). PMID: 10498817. |
| Okano, H., Sakakibara, S., Imai, T., Kaneko, Y. and Goldman, S.A.: Musashi1, a universal marker for CNS stem cells of vertebrate animals. In: Neuronal precursor cell biology and application for treatment of inborn errors of metabolism. Ed: N. Sakuragawa. National Center of Neurology and Psychiatry (Japan), 1999, pp. 159-167. |
| Leventhal, C., Rafii, S., Shahar, A., Goldman, S. Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma. Molec. Cell. Neurosci. 13: 450-464, 1999 (cover). PMID: 10383830. |
| Kang, J., Jiang, L., Goldman, S., Nedergaard, M. Astrocyte-mediated potentiation of inhibitory synaptic transmission. Nature Neurosci. 1: 683-692, 1998. PMID: 10196584. |
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Williams, S., Leventhal, C., Lemmon, V., Nedergaard, M., Goldman, S. Estrogen promotes the initial migration and inception of NgCAM-dependent calcium signaling by new neurons of the adult songbird brain. Molec. Cell Neurosci. 13:41-55, 1999. PMID: 10049530. 1998 |
| Lin, J., Cotrina, M., Bueno, E., Hansen, T., Hansen, A., Goldman, S., Nedergaard, M. Gap junction-mediated propagation and amplification of cell injury. Nature Neurosci. 1: 494-500, 1998. PMID: 1096547. |
| Goldman, S. Adult neurogenesis: from canaries to the clinic. J. Neurobiol. 36: 267-286, 1998. PMID: 9712309. |
| Jiang, W., McMurtry, J., Niedzwiecki, D., Goldman, S. IGF-1 is a radial cell-associated neurotrophin that promotes neuronal recruitment from the adult songbird edpendyma/subependyma. J. Neurobiol. 36: 1-15, 1998. PMID: 9658334. |
| Pincus, D., Keyoung, H., Harrison-Restelli, C., Sakakibara, S., Okano. H., Goodman, R., Fraser, R., Edgar, M., Nedergaard, M., Goldman, S. FGF2/BDNF-associated maturation of new neurons generated from adult human subependymal cells. Annals Neurol. 43: 576-585, 1998. PMID: 9585351. |
| Wang, S., Wu, H., Jiang, W., Isdell, F., Delohery, F., Goldman, S. Isolation of neuronal precursors by sorting embryonic forebrain transfected with GFP regulated by the T1 tubulin promoter. Nature Biotechnol. 16:196-201, 1998. PMID: 9487530. |
| Pincus, D., Goodman, R., Fraser, R., Nedergaard, M., Goldman, S. Neural stem and progenitor cells: a strategy for gene therapy and brain repair. Neurosurgery 42: 858-868, 1998. PMID: 9574651. |
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Goldman, S., Luskin, M. Strategies utilized by migrating neurons of the postnatal vertebrate forebrain. Trends in Neurosci. 21:107-114, 1998 (cover photo). PMID: 9530917. 1997 |
| Goldman, S., Nedergaard, M., Harrison-Restelli, C., Jiang, W., Keyoung, H. M., Leventhal, C., Pincus, D., Shahar, A., Wang, S. Neural precursors and neuronal production in the adult mammalian forebrain. Ann. N.Y. Acad. Sci. 835: 30-55, 1997. PMID: 9616760. |
| Goldman, S., Kirschenbaum, B., Harrison, C., Thaler, H. Neuronal precursors of the adult rat ventricular zone persist into senescence, with no decline in spatial extent or response to BDNF. J. Neurobiol. 32: 554-566, 1997 (cover photo). PMID: 9183737. |
| Goldman, S. Comparative strategies of subependymal neurogenesis in the adult forebrain. In: Isolation, characterization and utilization of CNS stem cells. F. Gage, Y. Christen, Eds. Fondation IPSEN Symposia: Springer-Verlag, 1997, pp. 43-65. |
| Goldman, S., Plum, F. Compensatory regeneration of the damaged adult human brain: Neuroplasticity in clinical perspective. In: Brain Plasticity, Advances in Neurology, vol. 73. Freund, Sabel, White, Eds. Lippincott-Raven: Philadelphia, 1997, pp. 99-107. |
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Pincus, D., Harrison-Restelli, C., Barry, J., Goodman, R., Fraser, R. A. R., Nedergaard, M., Goldman, S. In vitro neurogenesis by adult human epileptic temporal neocortex. Clinical neurosurgery. 44: 17-25, 1997. PMID: 10079997. 1996 |
| Goldman, S., Zukhar, A., Barami, K., Mikawa, T., Niedzwiecki, D. Ependymal/subependymal zone cells of the postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo. J. Neurobiol., 30: 505-520, 1996. PMID: 8844514. |
| Nedergaard, M., Goldman, S. Spreading depression-A gap junction-mediated event? In: Gap junctions in the nervous system. D. Spray, R. Dermietzel, eds. R. G. Landes: Austin, 1996, pp. 301-312. |
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Goldman, S., Williams, S., Barami, K., Lemmon, V., Nedergaard, M. Transient coupling of NgCAM expression to NgCAM-dependent calcium-signaling during migration of new neurons in the adult songbird brain. Mol. Cell. Neurosci., 7: 29-45, 1996. PMID: 8812057. 1995 |
| Nedergaard, M., Cooper, A., Goldman, S. Gap junctions are required for the propagation of spreading depression. J. Neurobiol. 28: 433-444, 1995. PMID: 8592104. |
| Goldman, S. Neurogenesis and neuronal precursor cells in adult forebrain. The Neuroscientist 1:338-350, 1995. |
| Barami, K., Iversen, K., Furneaux, H., Goldman, S. Hu proteins as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain. J. Neurobiol., 28: 82-101, 1995. PMID: 8586967. |
| Hidalgo, A., Iversen, K., Barami, K., Goldman, S. Estrogens and non-estrogenic ovarian influences combine to promote the recruitment and decrease the turnover of new neurons in the adult female canary brain. J. Neurobiol., 27: 470-487, 1995. PMID: 7561828. |
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Kirschenbaum, B., Goldman, S. Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone. Proc. Natl. Acad. Sci. 92: 210-214, 1995. PMCID: PMC42847. 1994 |
| Barami, K., Lemmon, V., Goldman, S. N-cadherin and Ng-CAM/8D9 are involved serially in the migration of newly generated Neurons into the adult songbird brain. Neuron 13: 567-582, 1994. PMID: 7522481. |
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Kirschenbaum, B., Nedergaard, M., Preuss, A., Barami, K., Fraser, R., Goldman, S. In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain. Cerebral Cortex 4: 576-589, 1994. PMID: 7703685. 1993 |
| Nedergaard, M., Goldman, S. Carrier mediated transport of lactic acid in cultured neurons and astrocytes. Am. J. Physiol. 265: R282-289, 1993. PMID: 8368382. |
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Goldman, S., Lemmon, V, Chin, S. Migration of newly generated neurons upon ependymally derived radial guide cells in explant cultures of the adult songbird forebrain. Glia 8:150-160, 1993 (cover photo). PMID: 8225557. 1992 |
| Goldman, S., Nedergaard, M. Newly generated neurons of the adult songbird brain become functionally active in long-term culture. Dev. Brain Res. 68:217-223, 1992. PMID: 1394968. |
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Goldman, S., Zaremba, A., Niedzwiecki, D. In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain. J. Neuroscience 12: 2532-2541, 1992. PMID: 1613545. 1991 |
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Nedergaard, M., Goldman, S., Desai, S., Pulsinelli, W. Acid-induced death in neurons and glia. J. Neuroscience 11:2489-2497, 1991. PMID: 1869926. 1990 |
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Goldman, S. Neuronal development and migration in explant cultures of the adult canary forebrain. J. Neuroscience 10: 2931-2939, 1990. PMID: 2204684. 1989 |
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Goldman, S., Pulsinelli, W., Clarke, W., Kraig, R., Plum, F. The effects of extracellular acidosis on neurons and glia in vitro. J. Cereb. Blood Flow Metab. 9: 471-477, 1989. PMID: 2738113. 1987 |
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Goldman, S., Gandy, S. Squamous carcinoma as a late complication of intra-cerebroventricular epidermoid. J. Neurosurg. 66:618-620, 1987. 1985 |
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Goldman, S., Monahan, J., Schneider, B. The regional and subcellular development of cholecystokinin immuno-reactivity in vertebrate brain. Dev. Brain Res. 22:237-246, 1985. PMID: 4052814. 1983 |
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Goldman, S., Nottebohm, F. Neuronal production, migration and differentiation in a vocal control nucleus of the adult female canary brain. Proc. Natl. Acad. Sci. 80:2390-2394, 1983. PMID: 6572982. 1982 |
| Lorenz, D., Goldman, S. Vagal mediation of the cholecystokinin satiety effect in rats. Physiol. Behav. 29:599-604, 1982. PMID: 6294698. |