Steven A. Goldman, M.D., Ph.D.

Contact Information

goldman@sund.ku.dk

Research Focus:

Identify the expression patterns of the major categories of stem and progenitor cells of the adult human brain and to use that information to define the signaling pathways that distinguish one progenitor from another, as well as those that distinguish brain tumor stem and progenitor cells from their normal counterparts.

Patents

Issued US Patents (31 issued in US; 19 pending published PCTs listed in prosecution; list does not include >100 corresponding international patents)

Method for Separating Cells
US Patent No. 6,245,564; filed 1/23/97; issued 6/12/01

Inventors: Steven Goldman and Hong Wu; Owner: Cornell Research Foundation, Inc.

Method for Separating Cells
US Patent No. 6,692,957; filed 4/17/01; issued 2/17/04

Inventors: Steven Goldman and Hong Wu; Owner: Cornell Research Foundation, Inc.

Discovery, Localization, Harvest and Propagation of an FGF2 and BDNF-Responsive Population of Neural and Neuronal Progenitor Cells in the Adult Human Forebrain
US Patent No. 6,812,027; filed 3/18/99; issued 11/2/04

Inventors: Steven Goldman and Maiken Nedergaard; Owner: Cornell Research Foundation, Inc.

Method of Inducing Neuronal production in the Brain and Spinal Cord
US Patent No. 7,037,493; filed 5/1/01; issued 5/2/06

Inventors: Steven Goldman and Abdellatif Benraiss; Owner: Cornell Research Foundation, Inc.

Telomerase-Immortalized Neural Progenitor Cells
US Patent No. 7,150,989; filed 8/9/02; issued 12/19/06

Inventors: Steven Goldman and Neeta Roy; Owner: Cornell Research Foundation, Inc.

Enriched Preparation of Human Fetal Multipotential Neural Stem Cells
US Patent No. 7,468,277; filed 12/22/2000; issued 12/23/08

Inventors: Steven A. Goldman and Hideyuki Okano; Owner: Cornell Research Foundation, Inc.

Non-Human Animals with Human-Glial Chimeric Brains
US Patent No. 7,524,491; filed 1/16/08, issued 4/28/09

Inventors: Steven Goldman and Martha S. Windrem; Owner: University of Rochester

Enhancing Neurotrophin-Induced Neurogenesis by Endogenous Neural Progenitor Cells by Concurrent Overexpression of BDNF and an Inhibitor of a Pro-Gliogenic Bone Morphogenetic Protein
US Patent No. 7,576,065; filed 2/14/03; issued 8/18/09

Inventors: Steven Goldman, Eva Chmielnicki and Aris Economides; Owner: Cornell Research Foundation, Inc.

Neuronal Progenitor Cells from Hippocampal Tissue and a Method for Isolating and Purifying Them
US Patent No. 7,785,882; filed 1/18/01, issued 8/31/10.

Inventor: Steven Goldman; Owner: Cornell Research Foundation, Inc.

Method of Inducing Neuronal Production in the Caudate Nucleus and Putamen
US Patent No. 7,803,752; filed 4/3/06; issued 9/28/10

Inventors: Steven Goldman and Abdellatif Benraiss; Owner: Cornell Research Foundation, Inc.

Method of Inducing Neuronal Production in the Caudate Nucleus and Putamen
US Patent No. 7,803,752; filed 4/3/06; issued 9/28/10

Inventors: Steven Goldman and Abdellatif Benraiss; Owner: Cornell Research Foundation, Inc.

Method of Inducing Neuronal Production in the Brain and Spinal Cord
US Patent No. 7,807,145; filed 4/3/06; issued 10/5/10

Inventors: Steven Goldman and Abdellatif Benraiss; Owner: Cornell Research Foundation, Inc.

Purines are Self-Renewing signals for Neural Stem cells, and Purine Receptor Antagonists Promote Neuronal and Glial Differentiation Therefrom
US Patent No. 7,829,332; filed 2/10/05; issued 11/9/2010

Inventors: Steven A. Goldman, Maiken Nedergaard, Jane Lin; Owner: Cornell Research Foundation, Inc.

Purine Receptor Inhibition as a Therapeutic Strategy in Spinal Cord and Brain
US Patent No. 7,923,448; filed 11/2/04; issued 4/12/11

Inventors: Steven Goldman and Maiken Nedergaard; Owner: Cornell Research Foundation, Inc.

Myelination of Congenitally Dysmyelinated Forebrains using Oligodendrocyte Progenitor Cells
US Patent No. 8,206,699; filed 4/29/08; issued 6/26/12

Inventors: Steven Goldman, Neeta Roy and Martha Windrem; Owner: Cornell Research Foundation, Inc.

Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
A divisional of U.S. Patent 8,206,699, issued 6/26/12
U.S. Patent 9,371,513, issued June 21, 2016

Inventors: Steven Goldman, Neeta Roy and Martha Windrem; Owner: University of Rochester

Method for Isolating and Purifying Oligodendrocytes and Oligodendrocyte Progenitor Cells
U.S. Patent No. 8,263,402; filed 3/31/99; issued 9/11/12

Inventors: Steven Goldman and Su Wang; Owner: Cornell Research Foundation, Inc.

Enriched or Purified Population of Motor Neurons and its Preparation from a Population of Embryonic Stem Cells
U.S. Patent No. 8,263,406; filed 6/10/04; issued date 9/11/2012

Inventors: Steven Goldman, Takahiro Nakano, Neeta Roy; Owner: Cornell Research Foundation, Inc.

Regulatory Sequences that Direct Gene Expression to Spinal Motor Neurons and Uses Thereof
U.S. Patent No. 8,524,499; filed 11/9/04; issued 9/3/13.

Inventors: Steven Goldman and Takahiro Nakano; Owner: Cornell Research Foundation, Inc.

Identification and Isolation of Multipotential Neural Progenitor Cells from the Subcortical White Matter of the Adult Human Brain
Patent No. 8,642,332; filed 3/4/04; issued 2/4/14

Inventors: Steven Goldman and Neeta Roy; Owner: Cornell Research Foundation, Inc.

Modulating the Production of Neurons and/or Oligodendrocytes from White Matter Progenitor Cells
U.S. Patent No. 8,945,921; filed 2/10/09; issued 2/3/2015

Inventors: Steven Goldman and Fraser Sim; Owner: Cornell Research Foundation, Inc.

Treating Myelin Diseases With Optimized Cell Preparations
U.S. Patent No. 9,709,553; filed 5/7/09; issued 7/18/2017

Inventors: Steven Goldman and Fraser Sim; Owner: University of Rochester

Non-Human Mammalian Model of a Human Degenerative Disorder, Uses Thereof, and Method for Treating Human Degenerative Disorders
U.S. Patent No. 9,724,432, issued 8/8/2017

Inventor: Steven Goldman; Owner: University of Rochester

Myelination of Congenitally Dysmyelinated Forebrains Using Oligodendrocyte Progenitor Cells
A divisional of U.S. Patent 9,371,513, issued June 21, 2016
U.S. Patent no. 10,190,095, issued 1/29/19.

Inventors: Steven Goldman, Neeta Roy and Martha Windrem; Owner: University of Rochester

Non-Human Mammalian Model of a Human Degenerative Disorder, Uses Thereof, and Method for Treating Human Degenerative Disorders
U.S. Patent No. 10,279,051 B2 (a divisional of 9,724,432, focusing on frontotemporal dementia); issued 5/7/2019

Inventor: Steven Goldman; Owner: University of Rochester

Modulating the Production of Neurons and/or Oligodendrocytes from White Matter Progenitor Cells
U.S. Patent No. 10,485,807; a divisional of 8,945,921; issued 11/26/2019

Inventors: Steven Goldman and Fraser Sim

Induced Pluripotent Cell-Derived Oligodendrocyte Progenitor Cells for the Treatment of Myelin Disorders
U.S. Patent No.: 10,450,546, issued 10/22/19

Inventors: Steven Goldman and Su Wang

Induced Pluripotent Cell-Derived Oligodendrocyte Progenitor Cells for Treatment of Myelin Disorders
U.S. Patent No. 10,626,369, issued 4/21/20 (a divisional of U.S. Patent No.: 10,450,546)

Inventors: Steven Goldman and Su Wang

A Human Glial Chimeric Model for Drug Candidate Assessment in Human Gliotrophic Viral Infections and Progressive Multifocal Encephalopathy (divisional filing)
US Patent No. 10,779,519, filed 5/12/15; issued 9/22/20

Inventors: Steven Goldman, Leonid Gorelick, Yoichi Kondo, and Martha Windrem; Owner: University of Rochester

Treating Myelin Diseases With Optimized Cell Preparations
U.S. Patent No. 11,344,582; a divisional of 9,709,553; filed 2/10/17; issued 5/31/2022

Inventors: Steven Goldman and Fraser Sim; Owner: University of Rochester

Non-Human Mammalian Model of a Human Degenerative Disorder, Uses Thereof, and Method for Treating Human Degenerative Disorder
U.S. Patent No. 11,596,700 (a divisional of 9,724,432, focusing on broader indications); issued 3/7/2023

Inventor: Steven Goldman; Owner: University of Rochester

Methods of Treating Neuropsychiatric Disorders
U.S. Patent 11,690,876, filed 5/10/17; issued 7/4/23
Patent Cooperation Treaty PCT serial no.: US2018/031961, filed 5/10/2018

Inventors: Steven Goldman and Maiken Nedergaard; Owner: University of Rochester

Pending US Patent Applications (all have corresponding PCTs and international filings):

Human iPS Cell-derived Glial Progenitor Cells for the Patient-Specific Treatment of Myelin Disorders
U.S. Application no. 61/761,584; filed 2/6/2013
U.S. Application no. 61/780,265; filed 3/13/2013 (allowed, issuance pending)
Patent Cooperation Treaty PCT serial no. PCT/US2014/015019, filed 2/6/14

Inventors: Steven Goldman; Owner: University of Rochester

Methods of Treating Schizophrenia and Other Neuropsychiatric Disorders
Patent Cooperation Treaty Serial no. PCT/US2019/037754, filed: 6/18/2019

Inventor: Steven Goldman; Owner: University of Rochester

Methods of Treating or Inhibiting Onset of Huntington's Disease
U.S. Application no. 62/688,174, filed 6/21/18
Patent Cooperation Treaty Serial no. PCT/US2019/037987, filed 6/19/2019

Inventor: Steven Goldman; Owner: University of Rochester

Cell type-specific immunoprotected cell lines
U.S. Application no. 62/875,883, filed 7/18/19
Patent Cooperation Treaty Serial no. PCT/US2020/042768, filed: 7/20/20

Inventors: Steven Goldman and Abdellatif Benraiss; Owner: University of Rochester

Identification of transplanted human glial cells (by PET)
U.S. Application no. 63/012,709, filed: 4/20/20
Patent Cooperation Treaty Serial no. PCT/US2021/028206, filed 4/20/21

Inventors: Steven Goldman, Gitte Moos Knudsen and Abdellatif Benraiss; Owners: University of Rochester and University of Copenhagen

GPR17 Promoter-Based Targeting and Transduction of Glial Progenitor Cells
U.S. Application no. 63/305,558, filed 2/1/22
Patent Cooperation Treaty Serial no. PCT/US2023/061751, filed 2/1/23

Inventors: Steven Goldman, John Mariani and Abdellatif Benraiss; Owner: University of Rochester

MicroRNA-Medicated Methods for Rejuvenating CNS Glial Populations
U.S. Application no. 17/968,984, filed 10/19/22 (as a conversion of U.S. Application no. 63/350,039, filed 6/8/22).
Patent Cooperation Treaty Serial no. PCT/US2022/047085, filed 10/19/22

Inventors: Steven Goldman and John Mariani; Owner: University of Rochester

Humanized Chimeras for the Prospective Assessment of Cell Addition and Replacement Therapies
U.S. Application no. 63/380,093, filed 10/20/21
Patent Cooperation Treaty Serial no. PCT/US2022/077825, filed 10/8/22

Inventors: Ricardo Vieira and Steven Goldman; Owner: University of Rochester and the University of Copenhagen

Gene Networks that Mediate Remyelination of the Human Brain
U.S. Application no. 62/805,202, filed 2/13/19
Patent Cooperation Treaty Serial no. PCT/US2020/017737, filed 2/11/20

Inventors: Steven Goldman and John Mariani; Owner: University of Rochester

Methods Of Generating A Population Of Neurons From Human Glial Progenitor Cells And Genetic Constructs For Carrying Out Such Methods
U.S. Application no. 63/305,570, filed 2/1/22
Patent Cooperation Treaty Serial no. PCT/US2023/061756, filed February 1, 2023

Inventors: Steven Goldman and Abdellatif Benraiss; Owner: University of Rochester

Compositions and Methods for Delivery of Agents to Inner Ear
U.S. Application no. 63/293,210, filed 12/23/21
Patent Cooperation Treaty Serial no. PCT/US2022/082226, filed 12/22/22

Inventors: Maiken Nedergaard, Steven Goldman; Owner: University of Rochester

Treatment of Age-Related White Matter Loss
U.S. Application no. 63/257,767, filed 10/20/21
Patent Cooperation Treaty Serial no. PCT/US2022/078344

Inventors: Ricardo Vieira and Steven Goldman; Owner: University of Rochester and University of Copenhagen

TCF7L2 Mediated Remyelination in the Brain
U.S. Application no. 63/378,092, filed 10/3/22 (a conversion of U.S. Application no. 63/274,763, filed 11/2/21)
Patent Cooperation Treaty Serial no. PCT/US2022/079028, filed 11/1/22

Inventors: Steven Goldman, Abdellatif Benraiss, John Mariani; Owner: University of Rochester

Treatment with Genetically Modified Cells, and Genetically Modified Cells Per Se, with Increased Competitive Advantage and/or Decreased Competitive Disadvantage
U.S. Application no. 63/257,853, filed 10/20/21
Patent Cooperation Treaty Serial no. PCT/US2022/078181, filed 10/16/22