Physiology of Astroglia
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Astrocytes are principal cells responsible for maintaining the brain homeostasis. Additionally, these glial cells are also involved in homocellular (astrocyte-astrocyte) and heterocellular (astrocyte-other cell types) signalling and metabolism. These astroglial functions require an expression of the assortment of molecules, be that transporters or pumps, to maintain ion concentration gradients across the plasmalemma and the membrane of the endoplasmic reticulum. Astrocytes sense and balance their neurochemical environment via variety of transmitter receptors and transporters. As they are electrically non-excitable, astrocytes display intracellular calcium and sodium fluctuations, which are not only used for operative signalling but can also affect metabolism. In this chapter we discuss the molecules that achieve ionic gradients and underlie astrocyte signalling.
Original language | English |
---|---|
Title of host publication | Neuroglia in Neurodegenerative Diseases |
Editors | Alexei Verkhratsky, Margaret S. Ho, Robert Zorec, Vladimir Parpura |
Number of pages | 47 |
Publisher | Springer |
Publication date | 2019 |
Pages | 45-91 |
Chapter | 3 |
ISBN (Print) | 978-981-13-9912-1 |
ISBN (Electronic) | 978-981-13-9913-8 |
DOIs | |
Publication status | Published - 2019 |
Series | Advances in Experimental Medicine and Biology |
---|---|
Volume | 1175 |
ISSN | 0065-2598 |
- Astrocytes, Brain homoeostasis, Ca signalling, Ion channels, Na signalling, Neurotransmitter receptors, SLC transporters
Research areas
Links
- http://europepmc.org/articles/pmc7265998?pdf=render
Accepted author manuscript
ID: 231243566