Center for Translational Neuromedicine

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  1. 2024
  2. Published

    Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ISMRM Imaging Neurofluids Study group” Workshop in Rome

    Agarwal, N., Lewis, L. D., Hirschler, L., Rivera, L. R., Naganawa, S., Levendovszky, S. R., Ringstad, G., Klarica, M., Wardlaw, J., Iadecola, C., Hawkes, C., Carare, R. O., Wells, J., Bakker, E. N. T. P., Kurtcuoglu, V., Bilston, L., Nedergaard, M., Mori, Y., Stoodley, M., Alperin, N. & 2 others, de Leon, M. & van Osch, M. J. P., 2024, In: Journal of Magnetic Resonance Imaging. 59, 2, 19 p.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Oxygen imaging of hypoxic pockets in the mouse cerebral cortex

    Beinlich, Felix Ralf Michael, Asiminas, Antonios, Untiet, Verena, Bojarowska, Zuzanna, Pla Requena, Virginia Teresa, Sigurdsson, B., Timmel, V., Gehrig, L., Graber, M. H., Hirase, Hajime & Nedergaard, Maiken, 2024, In: Science (New York, N.Y.). 383, 6690, p. 1471-1478 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Glymphatic system dysfunction in neurodegenerative diseases

    Beschorner, Natalie & Nedergaard, Maiken, 2024, In: Current Opinion in Neurology. 37, 2, p. 182-188 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  5. Published

    Transient but not chronic hyperglycemia accelerates ocular glymphatic transport

    Delle, Christine, Wang, X., Giannetto, M., Newbold, E., Peng, W., Gomolka, Ryszard Stefan, Ladrón-de-Guevara, A., Cankar, Neza, Nielsen, Elise Schiøler, Kjærby, Celia, Weikop, Pia, Mori, Yuki & Nedergaard, Maiken, 2024, In: Fluids and Barriers of the CNS. 21, 1, 13 p., 26.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The glymphatic system and Amyotrophic lateral sclerosis

    Eisen, A., Nedergaard, Maiken, Gray, E. & Kiernan, M. C., 2024, In: Progress in Neurobiology. 234, 10 p., 102571.

    Research output: Contribution to journal › Review › Research › peer-review

  7. Published

    Remyelination in the Central Nervous System

    Franklin, R. J. M., Bodini, B. & Goldman, Steven Alan, 2024, In: Cold Spring Harbor perspectives in biology. 16, 3, 39 p., a041371.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271

    Giannetto, M. J., Gomolka, Ryszard Stefan, Gahn-Martinez, D., Newbold, E. J., Bork, Peter Aleksander Rousing, Chang, E., Gresser, M., Thompson, T., Mori, Yuki & Nedergaard, Maiken, 2024, In: Glia. 72, 5, p. 982-998 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The role of glial pathology in Huntington's disease

    Goldman, Steven Alan, 2024, Huntington's Disease: Pathogenic Mechanisms and Implications for Therapeutics. Elsevier, p. 337-351 15 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  10. Published

    Single-nucleus expression characterization of non-enhancing region of recurrent high-grade glioma

    Patel, K. S., Tessema, K. K., Kawaguchi, R., Dudley, L., Alvarado, A. G., Muthukrishnan, S. D., Perryman, T., Hagiwara, A., Swarup, V., Liau, L. M., Wang, A. C., Yong, W., Geschwind, D. H., Nakano, I., Goldman, Steven Alan, Everson, R. G., Ellingson, B. M. & Kornblum, H. I., 2024, In: Neuro-Oncology Advances. 6, 1, 14 p., vdae005.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. E-pub ahead of print

    Anxiety control by astrocytes in the lateral habenula

    Tan, W., Ikoma, Y., Takahashi, Y., Konno, A., Hirai, H., Hirase, Hajime & Matsui, K., 2024, (E-pub ahead of print) In: Neuroscience Research.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Nutritional ketosis as treatment for alcohol withdrawal symptoms in female C57BL/6J mice

    Tonetto, S., Weikop, Pia & Thomsen, Morgane, 2024, In: Scientific Reports. 14, 1, 16 p., 5092.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Astrocytic chloride regulates brain function in health and disease

    Untiet, Verena, 2024, In: Cell Calcium. 118, 12 p., 102855.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. E-pub ahead of print

    Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain

    Vieira, R., Mariani, J. N., Huynh, N. P. T., Stephensen, Hans Jacob Teglbjærg, Solly, R., Tate, A., Schanz, S., Cotrupi, N., Mousaei, M., Sporring, Jon, Benraiss, A. & Goldman, Steven Alan, 2024, (E-pub ahead of print) In: Nature Biotechnology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats

    Wu, K. L. H., Liu, W. C., Wu, C. W., Fu, M. H., Huang, H. M., Tain, Y. L., Liang, C. K., Hung, C. Y., Chen, I. C., Hung, P. L., Lin, Y. J. & Hirase, Hajime, 2024, In: Journal of Nutritional Biochemistry. 126, 14 p., 109571.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2023
  17. Published

    Ketamine reduces electrophysiological network activity in cortical neuron cultures already at sub-micromolar concentrations – Impact on TrkB-ERK1/2 signaling

    Ahtiainen, A., Annala, I., Rosenholm, Marko, Kohtala, S., Hyttinen, J., Tanskanen, J. M. A. & Rantamäki, T., 2023, In: Neuropharmacology. 229, 11 p., 109481.

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    Prolactin in headache and migraine: A systematic review of clinical studies

    Al-Karagholi, M. A. M., Kalatharan, V., Ghanizada, Hashmat, Gram, C., Dussor, G. & dlt446, dlt446, 2023, In: Cephalalgia. 43, 2, 19 p.

    Research output: Contribution to journal › Review › Research › peer-review

  19. Published

    Prolactin in headache and migraine: A systematic review of preclinical studies

    Al-Karagholi, M. A. M., Kalatharan, V., Ghanizada, Hashmat, Dussor, G. & dlt446, dlt446, 2023, In: Headache. 63, 5, p. 577-584 8 p.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Published

    Using Fiber Photometry in Mice to Estimate Fluorescent Biosensor Levels During Sleep

    Andersen, Mie, Tsopanidou, Anastasia, Radovanovic, Tessa, Compere, V. N., Hauglund, Natalie Linea, Nedergaard, Maiken & Kjærby, Celia, 2023, In: Bio-protocol. 13, 15, 17 p., e4734.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension

    Beaman, Emily Eufaula, Bonde, A. N., Larsen, S. M. U., Ozenne, Brice Maxime Hugues, Lohela, T. J., Nedergaard, Maiken, Gislason, Gunnar Hilmar, Knudsen, Gitte Moos & Holst, S. C., 2023, In: Brain. 146, 3, p. 1141–1151 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow

    Bork, Peter Aleksander Rousing, Ladrón-De-Guevara, A., Christensen, A. H., Jensen, K. H., Nedergaard, Maiken & Bohr, T., 2023, In: Journal of the Royal Society Interface. 20, 204, 5 p., 20230050.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    SDREAMER: Self-distilled Mixture-of-Modality-Experts Transformer for Automatic Sleep Staging

    Chen, J., Yao, Y., Anderson, M., Hauglund, Natalie Linea, Kjærby, Celia, Untiet, Verena, Nedergaard, Maiken & Luo, J., 2023, p. 131-142. 12 p.

    Research output: Contribution to conference › Paper › Research › peer-review

  24. Published

    Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs

    Christiansen, Line Iadsatian, Ventura, G. C., Holmqvist, B., Aasmul-Olsen, Karoline, Lindholm, S. E. H., Lycas, M. D., Mori, Yuki, Secher, Jan Bojsen-Møller, Burrin, D. G., Thymann, Thomas, Sangild, Per Torp & Pankratova, Stanislava, 2023, In: Frontiers in Neuroscience. 17, 15 p., 1205819.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice

    Delle, Christine, Cankar, Neza, Digebjerg Holgersson, C., Hvorup Knudsen, H., Nielsen, Elise Schiøler, Kjærby, Celia, Mori, Yuki, Nedergaard, Maiken & Weikop, Pia, 2023, In: Scientific Reports. 13, 1, 11 p., 4137.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output

    Dietz, Andrea Grostøl, Weikop, Pia, Hauglund, Natalie Linea, Andersen, Mie, Petersen, Nicolas Caesar, Rose, Laura, Hirase, Hajime & Nedergaard, Maiken, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 40, 9 p., e2305071120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Protocol to study molecule exchange between venous blood and CSF in live mice using transcranial bioluminescence imaging

    Esmail, Tina, Nedergaard, Maiken & Beinlich, Felix Ralf Michael, 2023, In: STAR Protocols. 4, 4, 18 p., 102652.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism

    Gan, Y., Holstein-Rønsbo, Stephanie, Nedergaard, Maiken, Boster, K. A. S., Thomas, J. H. & Kelley, D. H., 2023, In: Journal of the Royal Society, Interface. 20, 206, 17 p., 20230288.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices

    Giacomoni, J., Habekost, Mette, Cepeda-Prado, E., Mattsson, B., Ottosson, D. R., Parmar, M. & Kajtez, Janko, 2023, In: STAR Protocols. 4, 1, 18 p., 102041.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

    Gomolka, Ryszard Stefan, Hablitz, L. M., Mestre, H., Giannetto, M., Du, Ting, Hauglund, Natalie Linea, Xie, L., Peng, W., Martinez, P. M., Nedergaard, Maiken & Mori, Yuki, 2023, In: eLife. 12, 36 p., e82232.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Ultrastructure of precapillary sphincters and the neurovascular unit

    Grubb, Søren, 2023, In: Vascular Biology. 5, 1, 15 p., e230011.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Locomotion Induces Fundamentally Different Patterns of Ca2+Signaling in Astrocytes and Neurons

    Hirase, Hajime & Nedergaard, Maiken, 2023, In: Function. 4, 4, 2 p., zqad028.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  33. Published

    Glymphatic influx and clearance are accelerated by neurovascular coupling: [Inkl. Correction]

    Holstein-Rønsbo, Stephanie, Gan, Y., Giannetto, M. J., Rasmussen, Martin Kaag, Sigurdsson, B., Beinlich, Felix Ralf Michael, Rose, Laura, Untiet, Verena, Hablitz, L. M., Kelley, D. H. & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, p. 1042–1053

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Air pollution, glymphatic impairment, and Alzheimer's disease

    Hussain, R., Graham, U., Elder, A. & Nedergaard, Maiken, 2023, In: Trends in Neurosciences. 46, 11, p. 901-911 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  35. Published

    Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema

    Hussain, R., Tithof, J., Wang, W., Cheetham-West, A., Song, W., Peng, W., Sigurdsson, B., Kim, D., Sun, Q., Peng, S., Pla Requena, Virginia Teresa, Kelley, D. H., Hirase, Hajime, Castorena-Gonzalez, J. A., Weikop, Pia, Goldman, Steven Alan, Davis, M. J. & Nedergaard, Maiken, 2023, In: Nature. 623, p. 992–1000 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Astrocytic contributions to Huntington's disease pathophysiology

    Khakh, B. S. & Goldman, Steven Alan, 2023, In: Annals of the New York Academy of Sciences. 1522, 1, p. 42-59 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  37. Published

    Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats

    Kiilerich, K. F., Lorenz, J., Scharff, M. B., Speth, N., Brandt, T. G., Czurylo, J., Xiong, M., Jessen, N. S., Casado-Sainz, A., Shalgunov, Vladimir, Kjærby, Celia, Satała, G., Bojarski, A. J., Jensen, Anders A., Herth, Matthias Manfred, Cumming, P., Overgaard, A. & Palner, M., 2023, In: Molecular Psychiatry. 28, 9, p. 3829-3841

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Reply to: 'Do all norepinephrine surges disrupt sleep?'

    Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Ding, F., Hirase, Hajime & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  39. Published

    Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles

    Lilius, T. O., Mortensen, K. N., Deville, C., Lohela, T. J., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Fiordaliso, E. M., Rosenholm, Marko, Kamphuis, C., Beekman, F. J., Jensen, A. I. & Nedergaard, Maiken, 2023, In: Journal of Controlled Release. 355, p. 135-148 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

    Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice

    Mathiesen, B. K., Miyakoshi, L. M., Cederroth, C. R., Tserga, E., Versteegh, C., Bork, Peter Aleksander Rousing, Hauglund, Natalie Linea, Gomolka, Ryszard Stefan, Mori, Yuki, Edvall, N. K., Rouse, S., Møllgård, Kjeld, Holt, J. R., Nedergaard, Maiken & Canlon, B., 2023, In: Science Translational Medicine. 15, 702, 13 p., eabq3916.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    The state of brain activity modulates cerebrospinal fluid transport

    Miyakoshi, L. M., Stæger, Frederik Filip Vinggaard, Li, Q., Pan, C., Xie, L., Kang, H., Pavan, C., Dang, J., Sun, Q., Ertürk, A. & Nedergaard, Maiken, 2023, In: Progress in Neurobiology. 229, 11 p., 102512.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    A mesothelium divides the subarachnoid space into functional compartments

    Møllgård, Kjeld, Beinlich, Felix Ralf Michael, Kusk, P., Miyakoshi, L. M., Delle, Christine, Pla Requena, Virginia Teresa, Hauglund, Natalie Linea, Esmail, Tina, Rasmussen, Martin Kaag, Gomolka, Ryszard Stefan, Mori, Yuki & Nedergaard, Maiken, 2023, In: Science. 379, 6627, p. 84-885

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging

    Nasu, Y., Aggarwal, A., Le, G. N. T., Vo, C. T., Kambe, Y., Wang, X., Beinlich, F. R. M., Lee, A. B., Ram, T. R., Wang, F., Gorzo, K. A., Kamijo, Y., Boisvert, M., Nishinami, S., Kawamura, G., Ozawa, T., Toda, H., Gordon, G. R., Ge, S., Hirase, H. & 5 others, Nedergaard, Maiken, Paquet, M. E., Drobizhev, M., Podgorski, K. & Campbell, R. E., 2023, In: Nature Communications. 14, 1, 17 p., 6598.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Glial progenitor cells of the adult human white and grey matter are contextually distinct

    Osorio, M. J., Mariani, J. N., Zou, L., Schanz, S. J., Heffernan, K., Cornwell, A. & Goldman, Steven Alan, 2023, In: Glia. 71, 3, p. 524-540 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes

    Ozawa, K., Nagao, Masaki, Konno, A., Iwai, Y., Vittani, Marta, Kusk, P., Mishima, Tsuneko, Hirai, H., Nedergaard, Maiken & Hirase, Hajime, 2023, In: International Journal of Molecular Sciences. 24, 17, 12 p., 13590.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model

    Parka, A., Degel, C., Dreyer, J., Richter, U., Hall, B., Bastlund, J. F., Laursen, B., Nedergaard, Maiken, Sotty, F. & Botta, P., 2023, In: Neurobiology of Disease. 178, 13 p., 106012.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model

    Parka, A., Volbracht, C., Hall, B., Bastlund, J. F., Nedergaard, Maiken, Laursen, B., Botta, P. & Sotty, F., 2023, In: Journal of Alzheimer's Disease. 93, 1, p. 247-262 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Structural characterization of SLYM—a 4th meningeal membrane

    Pla Requena, Virginia Teresa, Bitsika, S., Giannetto, M. J., Ladron-de-Guevara, A., Gahn-Martinez, D., Mori, Yuki, Nedergaard, Maiken & Møllgård, Kjeld, 2023, In: Fluids and Barriers of the CNS. 20, 1, 18 p., 93.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Astrocytes: integrators of arousal state and sensory context

    Rasmussen, R. N., Asiminas, Antonios, Carlsen, Eva Maria Meier, Kjærby, Celia & Smith, N. A., 2023, In: Trends in Neurosciences. 46, 6, 8 p.

    Research output: Contribution to journal › Review › Research › peer-review

  51. Published

    A SPECT-based method for dynamic imaging of the glymphatic system in rats

    Sigurdsson, B., Hauglund, Natalie Linea, Lilius, T. O., Mogensen, F. L. H., Mortensen, K. N., Beschorner, Natalie, Klinger, L., Bærentzen, S. L., Rosenholm, Marko, Shalgunov, Vladimir, Herth, Matthias Manfred, Mori, Yuki & Nedergaard, Maiken, 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 7, 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Development of 11C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species

    Staudt, Markus, Shalgunov, Vladimir, Nedergaard, Maiken & Herth, Matthias Manfred, 2023, In: Journal of Labelled Compounds and Radiopharmaceuticals. 66, 12, p. 393-399

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Astrocytes as master modulators of neural networks: Synaptic functions and disease-associated dysfunction of astrocytes

    Stogsdill, J. A., Harwell, C. C. & Goldman, Steven Alan, 2023, In: Annals of the New York Academy of Sciences. 1525, 1, p. 41-60 20 p.

    Research output: Contribution to journal › Review › Research › peer-review

  54. Published

    Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype

    Takahashi, K., Kanekiyo, K., Sakuda, K., Muto, Y., Iguchi, M., Matsuda, N., Hashimoto, Y., Kanai, K., Ogawa, H., Hirase, Hajime, Kakita, A., Bizen, N., Takebayashi, H., Kawaguchi, Y., Uzuki, M. & Kitazume, S., 2023, In: Journal of Neurochemistry. 166, 3, 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Behavioral and biochemical effects of alcohol withdrawal in female C3H/HeNRj and C57BL/6JRj mice

    Tonetto, S., Weikop, Pia, Brudek, T. & Thomsen, M., 2023, In: Frontiers in Behavioral Neuroscience. 17, 18 p., 1143720.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice

    Untiet, Verena, Beinlich, Felix Ralf Michael, Kusk, P., Kang, N., Ladrón-de-Guevara, A., Song, W., Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Bojarowska, Zuzanna, Sigurdsson, B., Deng, S., Hirase, Hajime, Petersen, Nicolas Caesar, Verkhratsky, A. & Nedergaard, Maiken, 2023, In: Nature Communications. 14, 1, 14 p., 1871.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington’s disease

    Villanueva, C. B., Stephensen, Hans Jacob Teglbjærg, Mokso, R., Benraiss, A., Sporring, Jon & Goldman, Steven Alan, 2023, In: Proceedings of the National Academy of Sciences USA (PNAS). 120, 24, 11 p., e2210719120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Age- and glaucoma-induced changes to the ocular glymphatic system

    Wang, X., Delle, Christine, Peng, W., Pla Requena, Virginia Teresa, Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, Ting, Libby, R. T. & Nedergaard, Maiken, 2023, In: Neurobiology of Disease. 188, 9 p., 106322.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life

    Wu, S-Y., Wen, Y., Serre, N. B. C., Laursen, C. C. H., Dietz, A. G., Taylor, B. R., Drobizhev, M., Molina, R. S., Aggarwal, A., Rancic, V., Becker, M., Ballanyi, K., Podgorski, K., Hirase, H., Nedergaard, M., Fendrych, M., Lemieux, M. J., Eberl, D. F., Kay, A. R., Campbell, R. E. & 1 others, Shen, Y., 2023, In: PLOS Biology. 20, 9, 23 p., e3001772.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. 2022
  61. Published

    Assessment of astrocytes as a mediator of memory and learning in rodents

    Akther, S. & Hirase, Hajime, 2022, In: Glia. 70, 8, p. 1484-1505 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Human integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype

    Andersen, Camilla, Uvebrant, K., Mori, Yuki, Aarsvold, S., Jacobsen, Stine, Berg, Lise Charlotte, Lundgren-åkerlund, E. & Lindegaard, Casper, 2022, In: Stem Cell Research & Therapy. 13, 15 p., 206.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Validation of ultrasonography for measurement of cartilage thickness in the equine carpus

    Andersen, Camilla, Griffin, J. F., Jacobsen, Stine, Østergaard, Stine, Walters, M., Mori, Yuki & Lindegaard, Casper, 2022, In: Veterinary Radiology & Ultrasound. 63, 4, p. 478-489 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Developmental trajectory of episodic-like memory in rats

    Asiminas, Antonios, Lyon, S. A., Langston, R. F. & Wood, E. R., 2022, In: Frontiers in Behavioral Neuroscience. 16, 20 p., 969871.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

    Asiminas, Antonios, Booker, S. A., Dando, O. R., Kozic, Z., Arkell, D., Inkpen, F. H., Sumera, A., Akyel, I., Kind, P. C. & Wood, E. R., 2022, In: Molecular Autism. 13, 1, 29 p., 49.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native A beta oligomers to rats

    Baerends, E., Soud, K., Folke, J., Pedersen, Anna-Kathrine, Henmar, S., Konrad, Lisa, Lycas, M. D., Mori, Yuki, Pakkenberg, B., Woldbye, David Paul Drucker, Dmytriyeva, O. & Pankratova, Stanislava, 2022, In: Acta Neuropathologica Communications. 10, 1, 21 p., 113.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice

    Benraiss, A., Mariani, J. N., Tate, A., Madsen, P. M., Clark, K. M., Welle, K. A., Solly, R., Capellano, L., Bentley, K., Chandler-Militello, D. & Goldman, Steven Alan, 2022, In: Cell Reports. 40, 9, 22 p., 111291.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Birthweight z-score and fat-free mass at birth predict body composition at 3 years in Danish children born from obese mothers

    Berglund, N. R., Lewis, Jack Ivor, Michaelsen, Kim F., Mølgaard, Christian, Renault, Kristina Martha & Carlsen, Eva Maria Meier, 2022, In: Acta Paediatrica. 111, 7, p. 1427-1434 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Systemic hypertonic saline enhances glymphatic spinal cord delivery of lumbar intrathecal morphine

    Blomqvist, K. J., Skogster, M. O. B., Kurkela, M. J., Rosenholm, Marko, Ahlström, F. H. G., Airavaara, M. T., Backman, J. T., Rauhala, P. V., Kalso, E. A. & Lilius, T. O., 2022, In: Journal of Controlled Release. 344, p. 214-224 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats

    Blomqvist, K. J., Dudek, K. A., Viisanen, H., Matlik, K., Ahlstrom, F. H. G., Laitila, J., Kalso, E. A., Rauhala, P. V. & Lilius, T. O., 2022, In: Journal of Neuroscience Research. 100, 1, p. 329-338 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    The glymphatic system: Current understanding and modeling

    Bohr, T., Hjorth, P. G., Holst, S. C., Hrabětová, S., Kiviniemi, V., Lilius, T., Lundgaard, I., Mardal, K. A., Martens, E. A., Mori, Yuki, Nägerl, U. V., Nicholson, C., Tannenbaum, A., Thomas, J. H., Tithof, J., Benveniste, H., Iliff, J. J., Kelley, D. H. & Nedergaard, Maiken, 2022, In: iScience. 25, 9, 33 p., 104987.

    Research output: Contribution to journal › Review › Research › peer-review

  72. Published

    The role of central serotonergic markers and estradiol changes in perinatal mental health

    Borgsted, C., Høgh, S., Høgsted, E. S., Fonnesbech-Sandberg, L., Ekelund, Kim, Albrechtsen, C. K., Wiis, J. T., Hegaard, Hanne Kristine, Cvetanovska, E., Juul, Anders, Frederiksen, H., Pinborg, Anja, Weikop, Pia & Frøkjær, Vibe Gedsø, 2022, In: Acta Psychiatrica Scandinavica. 146, 4, p. 357-369 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    More than meets the eye: The metabolic state of the body shapes visual sensations

    Carlsen, Eva Maria Meier & Rasmussen, R. N., 2022, In: Cell Metabolism. 34, 1, p. 9-10 2 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  74. Published

    Versatile treadmill system for measuring locomotion and neural activity in head-fixed mice

    Carlsen, Eva Maria Meier, Nedergaard, Maiken & Rasmussen, R. N., 2022, In: STAR Protocols. 3, 4, 14 p., 101701.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    Dorsal striatal dopamine induces fronto-cortical hypoactivity and attenuates anxiety and compulsive behaviors in rats

    Casado-Sainz, A., Gudmundsen, F., Baerentzen, S. L., Lange, D., Ringsted, A., Martinez-Tejada, I., Medina, S., Lee, H., Svarer, C., Keller, S. H., Schain, M., Kjærby, Celia, Fisher, P. M., Cumming, P. & Palner, M., 2022, In: Neuropsychopharmacology. 47, p. 454–464 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression

    Dam, H., Buch, J. O. D., Nielsen, A. B., Weikop, Pia & Jørgensen, Martin Balslev, 2022, In: Translational Neuroscience. 13, 1, p. 320-326 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

    Du, T., Mestre, H., Kress, B. T., Liu, G., Sweeney, A. M., Samson, A. J., Rasmussen, M. K., Mortensen, K. N., Bork, P. A. R., Peng, W., Olveda, G. E., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Hirase, H. & 2 others, Mori, Yuki & Nedergaard, Maiken, 2022, In: Brain. 145, 2, p. 787–797 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Depth-targeted intracortical microstroke by two-photon photothrombosis in rodent brain

    Fukuda, M., Matsumura, T., Suda, T. & Hirase, Hajime, 2022, In: Neurophotonics. 9, 2, 9 p., 021910.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Arterial responses to infusion of glucagon-like peptide-1 in humans: A randomized trial study

    Ghanizada, Hashmat, Christensen, R. H., Al-Karagholi, M. A. M., Elbahi, F. A., Coskun, H. & dlt446, dlt446, 2022, In: Peptides. 150, 8 p., 170736.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration

    Ghochani, Y., Muthukrishnan, S. D., Sohrabi, A., Kawaguchi, R., Condro, M. C., Bastola, S., Gao, F., Qin, Y., Mottahedeh, J., Iruela-Arispe, M. L., Rao, N., Laks, D. R., Liau, L. M., Mathern, G. W., Goldman, Steven Alan, Carmichael, S. T., Nakano, I., Coppola, G., Seidlits, S. K. & Kornblum, H. I., 2022, In: Cell Reports. 41, 3, 25 p., 111511.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations

    Helakari, H., Korhonen, V., Holst, S. C., Piispala, J., Kallio, M., Väyrynen, T., Huotari, N., Raitamaa, L., Tuunanen, J., Kananen, J., Järvelä, M., Tuovinen, T., Raatikainen, V., Borchardt, V., Kinnunen, H., Nedergaard, Maiken & Kiviniemi, V., 2022, In: Journal of Neuroscience. 42, 12, p. 2503-2515 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Biophysical Modeling of Dopaminergic Denervation Landscapes in the Striatum Reveals New Therapeutic Strategy

    Heltberg, Mathias Spliid, Awada, H. N., Lucchetti, Alessandra, Jensen, Mogens Høgh, Dreyer, J. K. & Rasmussen, R. N., 2022, In: eNeuro. 9, 2, 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Brain lipidomics and neurodevelopmental outcomes in intrauterine growth restricted piglets fed dairy or vegetable fat diets

    Henriksen, Nicole Lind, Asmussen, K. S., Pan, X., Jiang, Pingping, Mori, Yuki, Christiansen, Line Iadsatian, Sprenger, R. R., Ejsing, C. S., Pankratova, Stanislava & Thymann, Thomas, 2022, In: Scientific Reports. 12, 1, 3303.

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    An fMRI-compatible system for targeted electrical stimulation

    Jørgensen, Louise Møller, Baandrup, A. O., Mandeville, J., Glud, A. N., Sørensen, J. C. H., Weikop, Pia, Jespersen, B., Hansen, Adam Espe, Thomsen, C. & Knudsen, Gitte Moos, 2022, In: Journal of Neuroscience Methods. 378, 109659.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Increased interictal synchronicity of respiratory related brain pulsations in epilepsy

    Kananen, J., Järvelä, M., Korhonen, V., Tuovinen, T., Huotari, N., Raitamaa, L., Helakari, H., Väyrynen, T., Raatikainen, V., Nedergaard, Maiken, Ansakorpi, H., Jacobs, J., LeVan, P. & Kiviniemi, V., 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 10, p. 1840-1853 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

    Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2022, In: Nature Neuroscience. 25, p. 1059–1070 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment

    Ladrón-de-Guevara, A., Shang, J. K., Nedergaard, Maiken & Kelley, D. H., 2022, In: Journal of Theoretical Biology. 542, 111103.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

    Lilius, T. O., Rosenholm, Marko, Klinger, L., Mortensen, K. N., Sigurdsson, B., Mogensen, F. L., Hauglund, Natalie Linea, Nielsen, Malthe Skytte Nordentoft, Rantamaki, T. & Nedergaard, Maiken, 2022, In: iScience. 25, 10, 17 p., 105250.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies

    Liu, G., Ladrón-de-Guevara, A., Izhiman, Y., Nedergaard, Maiken & Du, Ting, 2022, In: Fluids and Barriers of the CNS. 19, 1, 24 p., 101.

    Research output: Contribution to journal › Review › Research › peer-review

  90. Published

    The glymphatic system: implications for drugs for central nervous system diseases

    Lohela, T. J., Lilius, T. O. & Nedergaard, Maiken, 2022, In: Nature Reviews Drug Discovery. 21, 10, p. 763-779 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters

    Lolansen, Sara Diana, Rostgaard, Nina, Barbuskaite, Dagne, Capion, T., Olsen, M. H., Norager, N. H., Vilhardt, Frederik, Andreassen, Søren Norge, Toft-Bertelsen, Trine Lisberg, Ye, F., Juhler, Marianne, Keep, R. F. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 19 p., 62.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Pretargeted Imaging beyond the Blood–Brain Barrier: Utopia or Feasible?

    Lopes van den Broek, S., Shalgunov, Vladimir, García Vázquez, R., Beschorner, Natalie, Bidesi, N. S. R., Nedergaard, Maiken, Knudsen, Gitte Moos, Sehlin, D., Syvänen, S. & Herth, Matthias Manfred, 2022, In: Pharmaceuticals. 15, 10, 13 p., 1191.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity

    Madsen, M. K., Petersen, A. S., Stenbæk, Dea Siggaard, Sorensen, I. M., Schionning, H., Fjeld, T., Nykjaer, C., Larsen, S. M. U., Grzywacz, M., Mathiesen, T., Klausen, I., Hansen, O. O., Brendstrup-Brix, K., Linnet, Kristian, Johansen, Sys Stybe, Fisher, P. M., Jensen, Rasmus Herlo Beenfeldt, Knudsen, Gitte Moos & Madsen, M. K., 2022, medRxiv, 17 p.

    Research output: Working paper › Preprint › Research

  94. Published

    TUBE project: Transport-derived ultrafines and the brain effects

    Martikainen, M. V., Aakko-Saksa, P., Broek, L. V. D., Cassee, F. R., Carare, R. O., Chew, S., Dinnyes, A., Giugno, R., Kanninen, K. M., Malm, T., Muala, A., Nedergaard, M., Oudin, A., Oyola, P., Pfeiffer, T. V., Rönkkö, T., Saarikoski, S., Sandström, T., Schins, R. P. F., Topinka, J. & 4 others, Yang, M., Zeng, X., Westerink, R. H. S. & Jalava, P. I., 2022, In: International Journal of Environmental Research and Public Health. 19, 1, 14 p., 311.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer’s disease

    Mestre, H., Verma, N., Greene, T. D., Lin, L. J. A., Ladron-de-Guevara, A., Sweeney, A. M., Liu, G., Thomas, V. K., Galloway, C. A., de Mesy Bentley, K. L., Nedergaard, Maiken & Mehta, R. I., 2022, In: Nature Communications. 13, 1, 8 p., 3897.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    Physiological Mechanisms and Significance of Intracranial B Waves

    Newell, D. W., Nedergaard, Maiken & Aaslid, R., 2022, In: Frontiers in Neurology. 13, 13 p., 872701.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    SpAD Biofunctionalized Cellulose Acetate Scaffolds Inhibit Staphylococcus aureus Adherence in a Coordinating Function with the von Willebrand A1 Domain (vWF A1)

    Pendas, S., Asiminas, Antonios, Katranidis, A., Tsioptsias, C., Pitou, M., Papadopoulos, G. & Choli-Papadopoulou, T., 2022, In: Journal of Functional Biomaterials. 13, 17 p., 21.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Could dexmedetomidine be repurposed as a glymphatic enhancer?

    Persson, N. D. Å., Uusalo, P., Nedergaard, Maiken, Lohela, T. J. & Lilius, T. O., 2022, In: Trends in Pharmacological Sciences. 43, 12, p. 1030-1040 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  99. Published

    A real-time in vivo clearance assay for quantification of glymphatic efflux

    Plá, V., Bork, Peter Aleksander Rousing, Harnpramukkul, A., Olveda, G., Ladrón-de-Guevara, A., Giannetto, M. J., Hussain, R., Wang, W., Kelley, D. H., Hablitz, L. M. & Nedergaard, Maiken, 2022, In: Cell Reports. 40, 11, 20 p., 111320.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    An unnoticed player overseeing CSF flux

    Pla Requena, Virginia Teresa & Nedergaard, Maiken, 2022, In: Nature Cardiovascular Research. 1, 2 p.

    Research output: Contribution to journal › Comment/debate › Research

  101. Published

    Single cell mapping the evolution of the spatial processing centre within the brain

    Ralbovszki, Dorottya Maria, Bertelsen, Mads Frost, Buchmann, Kurt, Mori, Yuki, Gorodkin, Jan, Hemberg, M., Seemann, Ernst Stefan, Khodosevich, Konstantin & Hall, Vanessa Jane, 1 May 2022.

    Research output: Contribution to conference › Poster › Communication

  102. Published

    Fluid Transport in the Brain

    Rasmussen, Martin Kaag, Mestre, H. & Nedergaard, Maiken, 2022, In: Physiological Reviews. 102, p. 1025-1151 27 p.

    Research output: Contribution to journal › Review › Research › peer-review

  103. Published

    The elusive varicose astrocytes

    Rasmussen, R. N. & Smith, N. A., 2022, In: Trends in Neurosciences. 45, 2, p. 94-95 2 p.

    Research output: Contribution to journal › Comment/debate › Research

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