Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
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Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance. / Oe, Yuki; Wang, Xiaowen; Patriarchi, Tommaso; Konno, Ayumu; Ozawa, Katsuya; Yahagi, Kazuko; Hirai, Hirokazu; Tian, Lin; McHugh, Thomas J; Hirase, Hajime.
In: Nature Communications, Vol. 11, No. 1, 471, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
AU - Oe, Yuki
AU - Wang, Xiaowen
AU - Patriarchi, Tommaso
AU - Konno, Ayumu
AU - Ozawa, Katsuya
AU - Yahagi, Kazuko
AU - Hirai, Hirokazu
AU - Tian, Lin
AU - McHugh, Thomas J
AU - Hirase, Hajime
N1 - Correction to: Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance. DOI: 10.1038/s41467-020-17059-x
PY - 2020
Y1 - 2020
N2 - Astrocytes may function as mediators of the impact of noradrenaline on neuronal function. Activation of glial α1-adrenergic receptors triggers rapid astrocytic Ca2+ elevation and facilitates synaptic plasticity, while activation of β-adrenergic receptors elevates cAMP levels and modulates memory consolidation. However, the dynamics of these processes in behaving mice remain unexplored, as do the interactions between the distinct second messenger pathways. Here we simultaneously monitored astrocytic Ca2+ and cAMP and demonstrate that astrocytic second messengers are regulated in a temporally distinct manner. In behaving mice, we found that while an abrupt facial air puff triggered transient increases in noradrenaline release and large cytosolic astrocytic Ca2+ elevations, cAMP changes were not detectable. By contrast, repeated aversive stimuli that lead to prolonged periods of vigilance were accompanied by robust noradrenergic axonal activity and gradual sustained cAMP increases. Our findings suggest distinct astrocytic signaling pathways can integrate noradrenergic activity during vigilance states to mediate distinct functions supporting memory.
AB - Astrocytes may function as mediators of the impact of noradrenaline on neuronal function. Activation of glial α1-adrenergic receptors triggers rapid astrocytic Ca2+ elevation and facilitates synaptic plasticity, while activation of β-adrenergic receptors elevates cAMP levels and modulates memory consolidation. However, the dynamics of these processes in behaving mice remain unexplored, as do the interactions between the distinct second messenger pathways. Here we simultaneously monitored astrocytic Ca2+ and cAMP and demonstrate that astrocytic second messengers are regulated in a temporally distinct manner. In behaving mice, we found that while an abrupt facial air puff triggered transient increases in noradrenaline release and large cytosolic astrocytic Ca2+ elevations, cAMP changes were not detectable. By contrast, repeated aversive stimuli that lead to prolonged periods of vigilance were accompanied by robust noradrenergic axonal activity and gradual sustained cAMP increases. Our findings suggest distinct astrocytic signaling pathways can integrate noradrenergic activity during vigilance states to mediate distinct functions supporting memory.
U2 - 10.1038/s41467-020-14378-x
DO - 10.1038/s41467-020-14378-x
M3 - Journal article
C2 - 31980655
VL - 11
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 471
ER -
ID: 234875959