All publications for Steven A. Goldman, M.D., Ph.D. and The Goldman Lab

(Updated October 29 2018)


Osipovitch, M., Asenjo-Martinez, A., Mariani, J., Cornwell, A., Dhaliwal, S., Zou, L., Chandler-Militello, D., Wang, S., Li, X., Benraiss, S., Agate, R., Lampp, A., Benraiss, A, Windrem, M, Goldman, S.A. (2019) Human ESC-derived chimeric mouse models of Huntington’s Disease reveal cell-intrinsic defects in glial progenitor cell differentiation. Cell Stem Cell 24:107-122, 2019. PMID:30554964.

Liu, Z., Osipovitch, M., Bates, J., Chandler-Militello, D., Benraiss, A., Nedergaard, M., Tesar, P., Windrem, M., Goldman, S.A. Astroglial differentiation block in childhood-onset schizophrenia may be relieved by suppression of REST and TGFB/SMAD4-dependent signaling. Cell Reports 27:3832-3843, 2019. PMID: 31242417

Mariani JN, Zou L, Goldman SA. "Human Glial Chimeric Mice to Define the Role of Glial Pathology in Human Disease." Meth. Molec. Biol.2019 1936:311-331.


Cornwell, A., Osipovitch, M., Sim, F.J., Chandler-Militello, D., Pena, I., Benraiss, S., Goldman, S.A., Auvergne, R. Evolution of microRNA/mRNA networks in human glial progenitor cells during gliomagenesis. 2018, under review.
Windrem, M., Schanz, S., Zou, L., Chandler-Militello, D., Cornwell, A., Mariani, J., Goldman, S.A. Human glial progenitor cells effectively remyelinate the demyelinated adult brain. 2018, under review.
Liu, Z., Osipovitch, M., Bates, J., Chandler-Militello, D., Benraiss, A., Nedergaard, M., Tesar, P., Windrem, M., Goldman, S.A. Astroglial differentiation block in childhood-onset schizophrenia may be relieved by suppression of REST and TGFB/SMAD4-dependent signaling. 2018, under review.
*Osipovitch, M., Asenjo-Martinez, A., Cornwell, A., Dhaliwal, S., Zou, L., Chandler-Militello, D., Wang, S., Li, X., Benraiss, S., Agate, R., Lampp, A., Benraiss, A., Windrem, M., Goldman, S.A. hESC-based human glial chimeras reveal glial differentiation defects in Huntington Disease. Cell Stem Cell, 2018, in press.
Barker, R.A., Carpenter, M.K., Forbes, S., Goldman, S.A., Jamieson, C., Murry, C.E., Takahashi, J., Weir, G. The challenges of first-in-human stem cell clinical trials: What does his mean for ethics and institutional review boards? Stem Cell Reports. 10:1429-1431, 2018.
Goldman, S. Transplanted neural progenitors bridge gaps to benefit cord-injured monkeys. Nature medicine 24:388-390, 2018. PMID: 29634690

Osorio, J., Goldman, S.A. Neurogenetics of Pelizaeus-Merzbacher disease. Handbook of clinical neurology: 148:701-722, 2018. PMID: 29478609


Goldman, S.A. Patience pays in spinal repair. J. Clinical Invest. 127:3284-6. doi: 10.1172/JCI96650, 2017. PMID: 28825601
*Windrem, M., Osipovitch., Wang, S., Bates, J., Zou, L., Liu, Z., Schanz, S., Munir, J., Chandler-Militello, D., Miller, R., Nedergaard, M., Findling, R., Tesar, P.J., Goldman, S.A. Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia. Cell stem cell, 21:195-208. doi: 10.1016/j.stem.2017.06.012, 2017. PMID: 28736215
Sun, W., Cornwell A., Li, J., Peng, S., Osorio, M.J., Aalling, N., Wang, S., Benraiss, A., Lou, N., Goldman, S.A., Nedergaard, M. SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions. J. Neuroscience 37:4493-4507, 2017. doi: 10.1523/jneurosci. 3199-16. PMID: 28336567.
Khakh, B., Beaumont, V., Munoz-Sanjuan, I., Goldman, S.A., Grantyn, R. Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease. Trends in Neuroscience 40:422-437, 2017. doi: 10.1016/j.tins. 2017.05.002. PMID: 28578789.
Nevin, Z.S., Factor, D.C., Karl R.T., Douvaras, P., Laukka, J., Windrem, M.S., Goldman, S.A., Fossati, V., Hobson, G.M., Tesar, P.J. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes. Am. J. Hum. Genet. 100:617-634. doi: 10.1016/j.ajhg. 2017.03.005, 2017. PMID: 28366443.

Goldman, S.A. Progenitor cell-based treatment of glial disease.. Prog. Brain. Res. 231:165-189, doi: 10.1016/bs.pbr. 2017.02.010. 2017. PMID: 28554396.


Osorio, J., Goldman, S.A. Glial progenitor cell-based treatment of the childhood leukodystrophies.Exp. Neurol. 283:476-488. 10.1016/j.expneurol.2016.05.010, 2016. PMID: 27170209
Wang, Y., Zhao, Z., Rege, S.V., Wang, M., Si, G, Zhou, Y., Wang, S., Griffin, J.H., Goldman, S.A., Zlokovic, B.V. 3K3A-activated protein C stimulates post-ischemic neuronal repair by human neural stem cells in mice. Nature medicine 2016 Sep;22(9):1050-5. doi: 10.1038/nm.4154, 2016. PMID: 27548576.
Osorio MJ, Rowitch DH, Tesar P, Wernig M, Windrem MS, Goldman SA. Stem cell-based treatment of Pelizaeus-Merzbacher Disease. Stem Cells 35:311-315, 2016. doi: 10.1002/stem.2530, 2016. PMID: 27882623.
Liang, Q., Luo, Z., Zeng, J., Chen, W., Foo, S.-S., Lee, S.-A., Ge, J., Wang, S., Goldman, S.A., Zlokovic, B., Zhao, Z., Jung, J.U. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell stem cell. 19:663-71, 2016. PMID: 27524440
*Benraiss, A., Wang, S., Herrlinger, S., Li, X., Chandler-Militello, D., Mauceri, J., Toner, M., Lundgaard, I., Xu, Q., Ding, F., Wang, F., Kang, N., Kang, J., Curtin, P., Brunner, D., Windrem, M., Munoz-Sanjuan, I., Nedergaard, M., Goldman, S.A. Human glia can both induce and rescue aspects of phenotype in Huntington Disease. Nature Commun., 7:11758, doi: 10.1038/ncomms11758, 2016. PMID: 27273432
Nedergaard, M., Goldman, S.A. The glymphatic system of the brain. Scientific American 314:44-49, March, 2016. PMID: 27066643
Zhao, C., Deng, Y.,… van Es, J., Xin, M., Parry, L., Goldman, S.A., Clevers, H., Lu, Q.-R., Yu, K., Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature Commun. 7:10883, doi: 10.1038, 2016. PMID: 26955760
Zhang, L., He, X., Liu, L., Jiang, M., Zhao, C.,…Lazar, M., Goldman, S.A., Olson, E.N., Lu, Q. R. Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Developmental cell 36:316-330, 2016. PMID: 26859354
Goldman, S.A. Stem cell therapeutics for neurological disease: Facts, fantasies, and wishful thinking. Cell stem cell, 18:174-188, 2016. PMID: 26849304
Osorio, J. Goldman, S.A. Cell therapeutics for disorders of glia. In: Translational Neuroscience. M. Tuszynski, ed. Chapter 15: p. 275-96. Springer, 2016.
Lou, N., Takano, T., Pei, Y., Xavier, A., Goldman, S.A., Nedergaard, M. P2RY12-dependent microglial closure of the injured blood-brain barrier. Proc. Natl. Acad. Sci. 113:1074-9, 2016. PMID: 26755608

Auvergne, R., Wu, C., Benraiss, A., Connell, A., Au, S., Cornwell, A., Osipovitch, M., Hugo Guerrero-Cazares, Quinones-Hinojosa, A., Goldman, S.A. PAR1 inhibition suppresses A2B5-defined glioma-initiating cells and their derived gliomas. Oncogene 35: 3817-28, 2016. PMID: 26616854


Goldman, S.A., Kuypers, N.J. How to make an oligodendrocyte. Development 142:3983-95, 2015. PMID: 26628089
Illiff, J., Goldman, S.A., Nedergaard, M. Implications of the discovery of brain lymphatics. Lancet Neurology 14:997-9, 2015. PMID: 26376966
Xavier, A.L.R., Kress, B., Goldman, S.A., de Menezes, J. R., Nedergaard, M. A distinct population of microglia supports adult neurogenesis in the subventricular zone. J. Neuroscience 35:11848-61, 2015.
Goldman, S.A., Nedergaard, M., Windrem, M. Human glial chimeric mouse models of neurological disease. Glia, 63(8):1483-93, 2015.
Helman, G., …van der Knaap, M.S., Back, S.A., Damiani, S., Goldman, S.A., Petryniak, M., Rowitch, D., Messing, A., Wrabetz, L., Schiffmann, R., Eichler, F., Escolar, M.L., Vanderver, A. Disease-specific therapies in leukodystrophies and leukoencephalopathies. Molec. Genetics Metab. 114:527-536, 2015.

Franklin, R.J.M., Goldman, S.A. Glial Disease and Repair: Remyelination. Cold Spring Harbor Perspect. Biol. 7:a020594. In: Glia. B. Barres, M. Freedman, Stevens, B., eds. Cold Spring Harbor Press, 2015.


*Windrem, M., Schanz, S., Morrow, C., Munir, J., Chandler-Militello, D., Wang, S., Goldman, S.A. A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia. Journal of Neuroscience. 34:16153-61, 2014.
Kondo, Y., Windrem, M., Zou, L., Chandler-Militello, D., Schanz, S., Auvergne, R., Betstadt, S., Harrington, A., Johnson, M., Kazarov, A., Gorelik, L., Goldman, S.A. JC virus-infected human glial chimeric mice reveal progressive multifocal leukoencephalopathy to be an astrocytic disease. J. Clin. Invest., 124:5323-36, 2014 (cover; featured story, JCI Impact).
Autelitano, F., Loyaux, D.,…Wang, S., Auvergne, R., Badarinarayana, V., Smith, M., Guillemot, J., Goldman, S.A., Natesan, S., Ferrara, P., August, P. Identification of novel tumor-associated cell surface sialoglycoproteins in human glioblastoma tumors using quantitative proteomics. PloS one 9:e110316, 2014. PMID: 25360666
Xavier,A.L., Menezes, J.R., Goldman, S.A., Nedergaard M. Fine-tuning the central nervous system: microglial modeling of cells and synapses. Phil. Trans. Royal Soc. B 369 (1654), 2014.
Fox, I., Daley, G., Goldman, S.A., Huard, J., Kamp, T., Trucco, M. Pluripotential stem cells as therapy. Science 345:889-898, 2014.

Goldman, S.A., Osorio, J. So many progenitors, so little myelin. Nature neuroscience, 17(4):483-5, 2014. PMID: 24671061


Auvergne, R., Sim, F., Wang, S., Chandler-Militello, D., Burch, J., Al-Fanek, Y., Davis, D., Benraiss, A., Walter, K., Achanta, P., Johnson, M., Quinones-Hinojosa, A., Natesan, S., Ford, H., Goldman, S.A. Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes.Cell reports 3(6):2127-41, 2013. PMID: 23727239
*Benraiss, A., Toner, M., Xu, Q., Bruel-Jungerman, E., Rogers, E.H., Wang, F., Economides, A.N., Davidson, B.L., Kageyama, R., Nedergaard, M., Goldman, S.A. Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington’s disease, Cell stem cell 12(6):787-99, 2013. PMCID: PMC4051319
Goldman, S.A. White matter from fibroblasts. Nature biotechnology 31(5):412-3, 2013. PMID: 23657393
Guo, H, Zhao, Z, Yang, Q, Wang, M, Bell, R.D., Wang, S, Chow, N, Davis, T.P., Griffin, J.H., Goldman, S.A., Zlokovic, B.V. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J. Neuroscience 33(14):6181-90, 2013. PMCID: PMC3707621
*Han, X., Chen, M., Wang, F., Windrem, M., Wang, S., Shanz, S., Xu, Q., Oberheim, N., Bekar, L., Betstadt, S., Silva, A., Takano, T., Goldman, S.A., Nedergaard, M. Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell stem cell 12(3):342-53, 2013. PMCID: PMC3700554
Goldman, S.A., Chen, Z., Ye, R., Testosterone modulated angiogenesis and neurogenesis in the adult songbird brain. Neuroscience 239:139-48, 2013. PMID: 23291451

*Wang, S., Bates, J., Li, X., Schanz, S., Chandler-Militello, D., Levine, C., Maherali, N., Studer, L., Hochedlinger, K., Windrem, M.S., Goldman, S.A. Human iPS cell-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination, Cell stem cell 12(2):252-64, 2013. PMCID: PMC3700553


Sim, F., Goldman, S.A. Gene expression patterns of oligodendrocyte progenitor cells and oligodendroglia. In: Neuroglia, 3d ed., H. Kettenmann and B. Ransom, Eds. Chapter 29, pp. 358-373. Oxford Univ. Press, 2012.
Goldman, S.A., Nedergaard, M., Windrem, M. Glial progenitor cell-based treatment and modeling of neurological disease. Science 338(6106):491-5, 2012. PMCID: PMC3548656
McClain, C., Sim, F., Goldman, S.A. Pleiotrophin suppression of receptor tyrosine phosphatas maintains the self-renewal competence of fetal human oligodendrocyte progenitors. J. Neuroscience 32(43):15066-75, 2012. PMCID: PMC3700539
Iliff, J., Wang, M., Liao, Y., Plogg, B., Peng, W., Benveniste, H., Vates, G. E., Deane, R., Goldman, S.A., Nagelhus, E., Nedergaard, M. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Science Transl. Med. 4(147):147ra111, 2012. PMCID: PMC3551275. PMID: 22896675.
Benraiss, A., Bruel-Jungerman, E., Lu, G., Economides, A.N., Davidson, B., Goldman, S.A. Sustained induction of neuronal recruitment to the adult rat striatum by AAV4-delivered noggin and BDNF. Gene therapy 19(5):483-93, 2012. PMCID: PMC3655807

Oberheim, N., Goldman, S.A., Nedergaard, M. Heterogeneity of Astrocytic Form and Function. Methods Mol. Biol. 814:23-45, 2012. PMCID: PMC3506190


Goldman, S.A., Chen, Z. Perivascular instruction of cell genesis and fate in the adult brain. Nature neuroscience 14(11):1382-9, 2011. PMCID: PMC3655803
*Sim, F., McClain, C., Schanz, S.J., Protack, T.L., Windrem, M., Goldman, S.A. CD140a identifies a population of highly myelinogenic, migration-competent, and efficiently engrafting human oligodendrocyte progenitor cells. Nature biotechnology, 29 (10):934-41, 2011. PMCID: PMC3365580
Benraiss, A., Goldman, S.A. Cell therapy and induced neuronal replacement for Huntington’s Disease. Neurotherapeutics 8(4):577-90, 2011. PMCID: PMC3250300
Eyler, C.E., Wu Q., Yan K., MacSwords J.M., Chandler-Militello D., Misuraca K.L., Lathia J.D., Forrester M.T, Lee J., Stamler J.S., Goldman S.A., Bredel M., McLendon R.E., Sloan A.E., Hjelmeland A.B., Rich J.N. Glioma Stem Cell Proliferation and Tumor Growth are Promoted by Nitric Oxide Synthase-2. Cell 146(1):53-66, 2011. PMCID: PMC3144745
Bugiani, M., Boor, I., van Kollenburg, B., Postma, N., Polder, E., van Berkel, C., van Kesteren, R., Windrem, M., Hol, E., Scheper, G., Goldman, S.A., van der Knaap, M.S. Defective glial maturation in vanishing white matter disease. J. Neuropath. Exp. Neurol. 70(1):69-82, 2011. PMID: 21157376

Goldman, S.A. Progenitor cell-based treatment of the pediatric myelin disorders. Arch. Neurology, 68(7):848-56, 2011. PMCID: PMC3358919


Persson, A., Petritsch, C., Swartling, F., Itsara, M., Sim, F., Auvergne, R., Goldenbergm D.D., Vandenberg, S.R., Nguyen, K.N., Yakovenko, S., Ayers-Ringler, J., Nshiyama, A., Stallcup, W.B., Berger, M.S., Bergers, G., McKnight, T., Goldman, S.A., Weiss, W. Non-stem cell origin for oligodendroglioma. Cancer cell 18(6):669-82, 2010. PMCID: PMC3031116
Wang, S., Chandler, D., Lu, G., Roy, N.S., Zielke, A., Auvergne, R., Stanwood, N., Geschwind, D., Coppola, G., Nicolis, S., Sim, F., Goldman, S.A. Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting. J. Neuroscience 30(44):14635-48, 2010. PMCID: PMC3358973
Zhang, S., Li, B., Lovatt, D., Xu, J., Song, D., Goldman, S.A., Nedergaard, M., Hertz, L., Peng, L. 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'. Neuron Glia Biol. 6(2):113-25, 2010. PMID: 20846463

Hertz, L., Lovatt, D., Goldman, S.A. Nedergaard, M. Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i. Neurochem. Int. 57(4):411-20, 2010. PMCID: PMC2934885


Hartog, T.E., Dittrich, F., Pieneman, A., Jansen, R., Frankl-Vilches, C., Lessmann, V., Lilliehook, C., Goldman, S.A., Gahr, M. Brain-Derived Neurotrophic Factor Signaling in the HVC Is Required for Testosterone-Induced Song of Female Canaries. J. Neuroscience, 29(49):15511-9, 2009. PMCID: PMC3377376
Sim, F., Windrem, M., Goldman, S. Fate determination of adult human glial progenitor cells. Neuron glia biology 5(3-4):45-55, 2009. PMID:19807941
Peng, W., Cotrina, M., Han, X., Yu, H., Bekar, L., Blum, L., Takano, T., Tian, G., Goldman, S., Nedergaard, M. Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc. Natl. Acad. Sci. 106(30): 12489-93, 2009. PMCID: PMC2718350
Karumbayaram, S., Novitch, B., Patterson, M., Umbach, J., Richter, L., Lindgren, A., Conway, A., Clark, A., Goldman, S., Plath, K., Wiedau-Pazos, M., Kornblum, H., Lowry, W. Directed differentiation of human induced pluripotent stem cells (iPS) generates active motor neurons. Stem Cells 27(4):806-11, 2009. PMCID: PMC2895909
Oberheim, N., Takano, T., Han, X., He, W., Lin, J., Wang, F., Xu, Q., Wyatt, J., Pilcher. W., Ojemann, J., Ransom, B., Goldman, S., Nedergaard, M. Uniquely hominid features of adult human astrocytes. J. Neuroscience 29(10):3276-87, 2009. PMCID: PMC2819812

Karumbayaram, S., Kelly, T., Paucar, A.,…Charles, A., Goldman, S., Kornblum, H., Wiedau-Pazos, M. Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS. Dis. Model Mech. 2(3-4):189-95, 2009. PMCID: PMC2650191


Ben-Hur, T., Goldman, S. Prospects of cell therapy for disorders of myelin.tion. Ann. NY Acad. Sci. 1142:218-49, 2008. PMID: 18990129
Goldman, S., Natesan, S. A niche-defying feat: induced oligoneogenesis in the adult dentate gyrus. Cell stem cell 3:125-6, 2008. PMID: 18682232.
Goldman, S. From canaries to the clinic. Regenerative medicine 3:655-659, 2008. PMID: 18729789.
Goldman, S., Schanz, S., Windrem, M. Stem cell-based strategies for treating pediatric disorders of myelin.Human molecular genetics 17:R76-83, 2008. PMID: 18632701.
* Windrem, M., Schanz, S., Guo, M., Tian, G.-F., Washco, V., Moyle, C., Stanwood, N., Rasband, M., Roy, N.S., Nedergaard, M., Havton, L., Wang, S., Goldman, S. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell 2: 553–65, 2008. PMCID:PMC3358921
Sim, F., Lang, J., Compton, T., Guo, M., Wang, S., Roy, N., Schwartz, T., Pilcher, W., Goldman, S. Statin treatment of adult human Glial progenitors induces PPAR-mediated oligodendrocytic differentiation. Glia 56:954-962, 2008. PMID: 18383345.
Duncan, I., Goldman, S., Macklin, W., Rao, M., Weiner, L., Reingold, S. Stem cell therapy in multiple sclerosis: promise and controversy. Multiple Sclerosis 14:541-6, 2008. PMID: 18562508.
Kim, D.-H., Lilliehook, C., Roides, B., Chang, M., Mobashery, S., Goldman, S. Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain. J. Neuroscience 28:208-216, 2008. PMID: 18171938.

Goldman, S. Neurogenesis in the adult songbird: A model for inducible striatal neuronal addition. In: Adult neurogenesis. F. Gage, G. Kempermann, eds. Cold Spring Harbor Press, 2008, pp. 593-618.


Roy, N. S., Chandler-Militello, D., Lu, G., Wang, S., Goldman, S. Retrovirally-mediated telomerase immortalization of human neural progenitor cells. Nature protocols, 2:2815-2825, 2007. PMID: 18007617.
Lovatt, D., Sonnewald, U., Schousboe, A., He, W., Lin, J., Han, X., Takano, T., Sim, F., Wang, S., Goldman, S., Nedergaard, M. The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J. Neuroscience 27:12255-66, 2007. PMID: 17989291.
Shin, S., Sun, Y., Liu, Y., .....Stice, S., Smith, A., Goldman, S., Reubinoff, B., Zhan, M., Rao, M., Chestnut, J. Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue. Stem Cells 25:1298-1306, 2007. PMID: 17272497.
Cho, S. R., Benraiss, A., Chmielniecki, E., Samdani, A., Economides, A, Goldman, S. Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington's Disease. J. Clin. Invest., 117: 2889-2902, 2007. PMCID: PMC1978427.
Goldman, S. Disease targets and strategies for the therapeutic modulation of endogenous neural stem and progenitor cells. Clinical Pharm. Ther. (Nature Pub.), 82: 453-460, 2007. PMID: 17713467.
Ballabh, P., Xu, H., Hu, F., Braun, A., Smith, K., Ungvari, Z., Goldman, S., Csiszar, A. Nedergaard, M. Angiogenic inhibition reduces germinal matrix hemorrhage. Nature medicine, 13:477-485, 2007 (cover photo). PMID: 17401377.
Lin, J., Takano, T., Goldman, S., Nedergaard, M. Purinergic signaling regulates neural progenitor cell expansion and neurogenesis. Dev. Biol. 302:356-366, 2007. PMCID: PMC1924912.
Keyoung, H., Goldman, S. Glial progenitor-based repair of demyelinating neurological diseases. Neurosurg. Clin. N.A., 18:93-104, 2007. PMID: 17244557.
Goldman, S., Roy, N. S. Beal, M. F., Cleren, C. Large stem cell grafts could lead to erroneous interpretations of behavioral results?? Nature medicine 13:118-119, 2007 (correspondence). PMID: 17290261

Kanai, R., Tomita, H., Hirose, Y., Ohba, S., Goldman, S., Okano, H., Kawase, T., Yazaki, T. Augmented therapeutic efficacy of an oncolytic HSV1 mutant expressing ICP34.5 under the transcriptional control of musashi1 promoter in the treatment of malignant glioma. Human gene therapy 18:63-73, 2007. PMID: 17238803.


Lilliehook, C., Goldman, S. Microvascular influences on progenitor cell mobilization and fate in the adult brain. In: Blood-Brain Barriers, vol. 1. Dermietzel, R., Spray, D., Nedergaard, M., eds. Wiley-VCH. Weinheim, 2006, pp. 61-74.
Sim, F., Keyoung, H., Goldman, J.E., Roy, N., Goldman, S. Neurocytoma is a tumor of adult neuronal progenitor cells. J. Neuroscience 26:12544-12555, 2006. PMID: 17135416.
Roy, N.S., Cleren, C., Singh, S., Beal, F., Goldman, S. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nature medicine 12:1259-1268, 2006 (cover photo). PMID: 17057709.
Oberheim, N., Wang, X., Goldman, S., Nedergaard, M. Astrocytic complexity distinguishes the human brain. Trends in Neuroscience. 29:1-7, 2006. PMID: 16938356.
Goldman, S., Windrem, M. Cell replacement therapy in neurological disease. Phil. Trans. Royal. Soc. B. 361:1463-75, 2006. PMCID: PMC1664668.
Goldman, S.A., Lang, J., Roy, N.S., Schanz, S.J., Sim, F.J., Wang, S., Washco, V., Windrem, M.S. Progenitor cell-based myelination as a model for cell-based therapy of the central nervous system. In: Stem Cells in Reproduction and the Brain. Ernst Schering Res Found Workshop. 60:195-213, 2006. PMID: 16903424.
Sim, F., Lang, J., Waldau, B., Roy, N., Schwartz, T., Pilcher, W., Chandross, K., Natesan, S., Merrill, J., Goldman, S. Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Ann. Neurology 59:763-79, 2006. PMID: 16634042.
Goldman, S., Sim, F. Targeted induction of endogenous neural stem and progenitor cells: A new strategy for gene therapy of neurological disease. In: Gene Therapy of the Nervous System: From Bench to Bedside. Kaplitt, M., During, M., eds. Elsevier: San Diego, 2006, pp. 53-65.
Kanai, R., Eguchi, K., Takahashi, M., Goldman, S., Okano, H., Kawase, T., Yazaki, T. J. Enhanced therapeutic efficacy of oncolytic herpes vector G207 against human small cell lung cancer: Expression of an RNA-binding protein, Musashi1, as a marker for tailored gene therapy. Gene Medicine 8:1329-1340, 2006.

Kanai, R., Tomita, H., Shinoda, A., Takahashi, M., Goldman, S., Okano, H., Kawase, T., Yazaki, T. Enhanced therapeutic efficacy of G207 for the treatment of glioma through Musashi1 promoter retargeting of gamma34.5-mediated virulence. Gene therapy 13:106-16, 2006. PMID: 16163378.


Roy, N.S., Nakano, T., Kang, J., Nedergaard, M., Goldman, S. Enhancer-specific GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp. Neurol. 196:224-234, 2005. PMID: 16198339.
Chmielnicki, E., Goldman, S. Stem cells and cell-based therapy in neurodegenerative disease. In: Neuro-degenerative Diseases. F. Beal, A. Lang, A. Ludolph, eds. Cambridge Press. 2005, p. 347-362.
Nakano, T., Windrem, M., Zappavigna, V., Goldman, S. Identification of a conserved 125 base-pair Hb9 enhancer that specifies gene expression to spinal motor neurons. Dev. Biology 283: 474-485, 2005. PMID: 15913596.
Sim, F., Goldman, S. White matter progenitor cells reside in an oligodendrogenic niche. In: Opportunities and Challenges of Therapies Targeting CNS Regeneration. D. Perez, B. Mitrovic, A. Baron van Evercooren, eds. Ernst Schering Research Foundation/Springer: Berlin, 2005, pp. 61-82. PMID: 16315609.
Greene, M., Schill, K. ...Goldman, S., Greely, H, Martin, L, Miller, E, Siegel, A., Solter, D., Gearhart, J., McKhann, G., Faden, R. Moral issues of human to non-human primate neural grafting. Science, 309: 385-386, 2005. PMID: 16020716.
Goldman, S. Stem and progenitor cell-based therapy of the human CNS. Nature Biotechnol., 23:862-871, 2005. PMID: 16003375
Goldman, S., Sim, F. Neural progenitor cells of the adult brain. In: Stem Cells: Nuclear programming and therapeutic applications. Novartis Foundation Symposia, vol. 265. John Wiley, London, 2005, 66-92. PMID: 16050251.
Goldman, S. Position on stem cell research (reply to editorial comments) Neurology 65:1512-3, 2005.
Goldman, S. Neurology and the stem cell debate.(editorial) Neurology 64:1675-76, 2005. PMID: 15911788.

Goldman, S. A strong root for stem cells. Nature Cell Biol. 7:341, 2005


Goldman, S. Directed mobilization of endogenous neural progenitor cells: the intersection of stem cell biology and gene therapy. Curr. Opin. Molecular Ther. 6:466-472, 2004. PMID: 15537047.

Wang, X., Arcuino, G., Takano, T., Lin, J., Peng, W…, Wan, P., Li, P., Xu, Q., Liu, Q.S., Goldman, S., Nedergaard, M. P2X7 receptor inhibition improves recovery after spinal cord injury. Nature medicine, 10:821-7, 2004 (cover photo). PMID: 15258577.
Goldman, S. Neural progenitor cells of the adult human forebrain. In: Stem Cells and CNS Development. 2d ed. M. Rao, ed. Humana, Press: New York, 2005.
Goldman, S. Cellular plasticity of the adult human brain. In: From Neuroscience to Neurology: neuroscience, molecular medicine, and the therapeutic transformation of neurology, S. Waxman, ed. Amsterdam: Elsevier, 2005, pages 371-382.
Chmielnicki, E., Benraiss, A., Economides, A., Goldman, S. Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce the new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone. J. Neuroscience 24:2133-2142, 2004. PMID: 14999064.
Goldman, S. A brand-new bird (book review). J. Clin. Invest. 113:495, 2004. PMCID: PMC338274.
Roy, N.S., Nakano, T., Keyoung, H., Rashbaum, W., Carpenter, M., Kang, J., Nedergaard, M., Goldman, S. Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nature Biotechnol. 22:297-305, 2004. PMID: 14990951.
Windrem, M., Nunes, M., Rashbaum, W., Schwartz, T., Goodman, R., McKhann, G., Roy, N., Goldman, S. Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain. Nature medicine 10:93-97, 2004. PMID: 14702638.

Roy, N., Windrem, M., Goldman, S. A. Progenitor cells of the adult human subcortical white matter In: Myelin Biology and Disorders, vol. 1. R. Lazzarini, ed. Elsevier: Amsterdam, 2004, pp. 259-287.


Goldman, S. Glia as neural progenitor cells. Trends in neurosciences. 26: 590-96, 2003. PMID: 14585598.
Packer, M., Benraiss, A., Chmielnicki, E., Grinberg, A., Westphal, H., Goldman, S., Enikolopov, G. Nitric oxide negatively regulates mammalian adult neurogenesis. Proc. Natl. Acad. Sci. 100: 9566-71, 2003. PMCID: PMC170958.
Nedergaard, M., Ransom, B., Goldman, S. New roles for astrocytes: redefining the functional architecture of the brain. Trends in neurosciences 26: 523-529, 2003. PMID: 14522144.
Nunes, M., Roy, N., Keyoung, H., Goodman, R., McKhann, G., Li, J., Nedergaard, M., Goldman, S. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nature medicine 9:239-247, 2003 (cover photo). PMID: 12627226.
Windrem, M., Roy, N., Wang, J., Goodman, R., McKhann, G., Goldman, S. Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the adult rat brain. J. Neurosci. Res. 69: 966-975, 2002 (cover photo). PMID: 12205690.

* Windrem, M., Roy, N., Nunes, M., Goldman, S. Identification, selection and use of adult human oligodendrocyte progenitor cells. In: Neural Stem Cells for Brain Repair. T. Zigova, E. Snyder, P. Sanberg, eds. Humana: NY, 2003, p. 69-88.


Chmielnicki, E., Goldman, S. Induced neurogenesis by endogenous progenitor cells in the adult mammalian brain. Prog. Brain. Res. 18: 2002. PMID: 12432784.
Goldman, S., Chmielnicki, E., Keyoung, H., Nunes, M., Roy, N., Windrem, M. Isolation and induction of adult neural progenitor cells. Clin. Neurosci. 2:70-79, 2002.
Goldman, S., Nedergaard, M. Erythropoietin strikes a new cord. Nature medicine 8:11-13, 2002. PMID: 12152030.
Louissaint, A., Rao, S., Leventhal, C., Goldman, S. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron 34:945-960, 2002 (featured article; see editorial: Neuron 34:856-58). PMID: 12086642.

Lin, J., Takano, T., Cotrina, M., Arcuino, G., Fried, V., Liu, S., Jiang, L., Lichtenberg, H, Haubrich, S., Willecke, K., Goldman, S., Nedergaard, M. Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells. J. Neuroscience 22:4302-4311, 2002. PMID: 12040035.


Keyoung, H., Roy, N., Louissant, A., Benraiss, A., Rashbaum, W., Okano, H., Goldman, S. High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain. Nature Biotechnol. 19:843-50, 2001. PMID: 11533643.
Benraiss, A., Chmielnicki, E., Lerner, K., Roh, D., Goldman, S. Adenoviral BDNF induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain. J. Neuroscience, 21: 6718-31, 2001. PMID: 11517261.
Sawamoto, K., Atsuyo Yamamoto, A., Kawaguchi, A., Yamaguchi, M., Mori, K., Goldman, S., Okano, H. Direct isolation of neuronal progenitor cells from transgenic mice co-expressing spectrally-distinct fluorescent proteins regulated by stage-specific neural promoters. J. Neurosci. Res. 65:220-227, 2001. PMID: 11494356.
Piper, D., Mujtaba, T., Keyoung, H., Roy, N., Goldman, S., Rao, M., Lucero, M. Identification and characterization of neuronal precursors and their progeny from human fetal tissue. J. Neurosci. Res. 66: 356-368, 2001. PMID: 11746353.
Sawamoto, K., Nakao, N., Kakishita, K., Ogawa, Y., Toyama, Y., Yamamoto, A., Yamaguchi, M., Mori, K., Itakura, T., Goldman, S., Okano, H. Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene. J. Neuroscience 21:3895-3903, 2001. PMID: 11356877.
Kawaguchi, A., Miyata, T., Sawamoto, K., Takashita, N., Akamatsu, W., Okabe, M., Tano, Y., Goldman, S., Okano, H. Nestin-EGFP transgenic mice: visualization of the self-renewal and multipotency of CNS stem cells. Molec. Cell. Neurosci. 17: 259-273, 2001. PMID: 11178865.

Goldman, S. Neural progenitor cells of the adult human forebrain. In: Stem Cells and CNS Development. M. Rao, ed. Humana, Press: New York, 2001, pp. 177-206.


Okano, H., Goldman, S. Identification and selection of neural progenitor cells. Neuroscience News 3: 27-31, 2000.
Goldman, S., Roy, N. Reply to "Human neural progenitor cells: better blue than green?" (comment) Nature medicine 6: 483-84, 2000. PMID: 10802678
Roy, N., Wang, S., Jiang, L., Kang, J., Benraiss, A., Restelli, C., Fraser, R., Couldwell, W., Kawaguchi, A., Okano, H., Nedergaard, M., Goldman, S. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nature medicine 6: 271-277, 2000 (cover photo). PMID: 10700228.
Wang, S., Roy, N., Benraiss, A., Goldman, S. Promoter-based isolation and fluorescence-activated sorting of mitotic neuronal progenitor cells from the adult mammalian ependymal/subependymal zone. Dev. Neurosci. 22:167-176, 2000. PMID: 10657708.
Roy, N., Benraiss, A., Wang, S., Fraser, R., Goodman, R., Couldwell, W., Nedergaard, M., Kawaguchi, A., Okano, H., Goldman, S. Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone. J. Neurosci. Res. 59: 321-331, 2000. PMID: 10679767.

Grafstein, B., Liu, S., Cotrina, M., Goldman, S., Nedergaard, M. Meningeal cells can communicate with astrocytes by calcium signaling. Annals Neurol. 47: 18-25, 2000. PMID: 10632097.


Roy, N., Wang, S., Harrison-Restelli, C., Benraiss, A., Fraser, R., Gravel, M., Braun, M., Goldman, S. Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter. J. Neuroscience 19:9986-9995, 1999. PMID: 10559406.
Simard, M., Couldwell, W., Zhang, W., Cotrina, M., Goldman, S., Nedergaard, M. Glucocorticoids-potent modulators of astrocytic calcium signaling. Glia 28:1-2, 1999 (cover photo). PMID: 10498817.
Okano, H., Sakakibara, S., Imai, T., Kaneko, Y. and Goldman, S.A.: Musashi1, a universal marker for CNS stem cells of vertebrate animals. In: Neuronal precursor cell biology and application for treatment of inborn errors of metabolism. Ed: N. Sakuragawa. National Center of Neurology and Psychiatry (Japan), 1999, pp. 159-167.
Leventhal, C., Rafii, S., Shahar, A., Goldman, S. Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma. Molec. Cell. Neurosci. 13: 450-464, 1999 (cover). PMID: 10383830.
Kang, J., Jiang, L., Goldman, S., Nedergaard, M. Astrocyte-mediated potentiation of inhibitory synaptic transmission. Nature Neurosci. 1: 683-692, 1998. PMID: 10196584.

Williams, S., Leventhal, C., Lemmon, V., Nedergaard, M., Goldman, S. Estrogen promotes the initial migration and inception of NgCAM-dependent calcium signaling by new neurons of the adult songbird brain. Molec. Cell Neurosci. 13:41-55, 1999. PMID: 10049530.


Lin, J., Cotrina, M., Bueno, E., Hansen, T., Hansen, A., Goldman, S., Nedergaard, M. Gap junction-mediated propagation and amplification of cell injury. Nature Neurosci. 1: 494-500, 1998. PMID: 1096547.
Goldman, S. Adult neurogenesis: from canaries to the clinic. J. Neurobiol. 36: 267-286, 1998. PMID: 9712309.
Jiang, W., McMurtry, J., Niedzwiecki, D., Goldman, S. IGF-1 is a radial cell-associated neurotrophin that promotes neuronal recruitment from the adult songbird edpendyma/subependyma. J. Neurobiol. 36: 1-15, 1998. PMID: 9658334.
Pincus, D., Keyoung, H., Harrison-Restelli, C., Sakakibara, S., Okano. H., Goodman, R., Fraser, R., Edgar, M., Nedergaard, M., Goldman, S. FGF2/BDNF-associated maturation of new neurons generated from adult human subependymal cells. Annals Neurol. 43: 576-585, 1998. PMID: 9585351.
Wang, S., Wu, H., Jiang, W., Isdell, F., Delohery, F., Goldman, S. Isolation of neuronal precursors by sorting embryonic forebrain transfected with GFP regulated by the T1 tubulin promoter. Nature Biotechnol. 16:196-201, 1998. PMID: 9487530.
Pincus, D., Goodman, R., Fraser, R., Nedergaard, M., Goldman, S. Neural stem and progenitor cells: a strategy for gene therapy and brain repair. Neurosurgery 42: 858-868, 1998. PMID: 9574651.

Goldman, S., Luskin, M. Strategies utilized by migrating neurons of the postnatal vertebrate forebrain. Trends in Neurosci. 21:107-114, 1998 (cover photo). PMID: 9530917.


Goldman, S., Nedergaard, M., Harrison-Restelli, C., Jiang, W., Keyoung, H. M., Leventhal, C., Pincus, D., Shahar, A., Wang, S. Neural precursors and neuronal production in the adult mammalian forebrain. Ann. N.Y. Acad. Sci. 835: 30-55, 1997. PMID: 9616760.
Goldman, S., Kirschenbaum, B., Harrison, C., Thaler, H. Neuronal precursors of the adult rat ventricular zone persist into senescence, with no decline in spatial extent or response to BDNF. J. Neurobiol. 32: 554-566, 1997 (cover photo). PMID: 9183737.
Goldman, S. Comparative strategies of subependymal neurogenesis in the adult forebrain. In: Isolation, characterization and utilization of CNS stem cells. F. Gage, Y. Christen, Eds. Fondation IPSEN Symposia: Springer-Verlag, 1997, pp. 43-65.
Goldman, S., Plum, F. Compensatory regeneration of the damaged adult human brain: Neuroplasticity in clinical perspective. In: Brain Plasticity, Advances in Neurology, vol. 73. Freund, Sabel, White, Eds. Lippincott-Raven: Philadelphia, 1997, pp. 99-107.

Pincus, D., Harrison-Restelli, C., Barry, J., Goodman, R., Fraser, R. A. R., Nedergaard, M., Goldman, S. In vitro neurogenesis by adult human epileptic temporal neocortex. Clinical neurosurgery. 44: 17-25, 1997. PMID: 10079997.


Goldman, S., Zukhar, A., Barami, K., Mikawa, T., Niedzwiecki, D. Ependymal/subependymal zone cells of the postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo. J. Neurobiol., 30: 505-520, 1996. PMID: 8844514.
Nedergaard, M., Goldman, S. Spreading depression-A gap junction-mediated event? In: Gap junctions in the nervous system. D. Spray, R. Dermietzel, eds. R. G. Landes: Austin, 1996, pp. 301-312.

Goldman, S., Williams, S., Barami, K., Lemmon, V., Nedergaard, M. Transient coupling of NgCAM expression to NgCAM-dependent calcium-signaling during migration of new neurons in the adult songbird brain. Mol. Cell. Neurosci., 7: 29-45, 1996. PMID: 8812057.


Nedergaard, M., Cooper, A., Goldman, S. Gap junctions are required for the propagation of spreading depression. J. Neurobiol. 28: 433-444, 1995. PMID: 8592104.
Goldman, S. Neurogenesis and neuronal precursor cells in adult forebrain. The Neuroscientist 1:338-350, 1995.
Barami, K., Iversen, K., Furneaux, H., Goldman, S. Hu proteins as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain. J. Neurobiol., 28: 82-101, 1995. PMID: 8586967.
Hidalgo, A., Iversen, K., Barami, K., Goldman, S. Estrogens and non-estrogenic ovarian influences combine to promote the recruitment and decrease the turnover of new neurons in the adult female canary brain. J. Neurobiol., 27: 470-487, 1995. PMID: 7561828.

Kirschenbaum, B., Goldman, S. Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone. Proc. Natl. Acad. Sci. 92: 210-214, 1995. PMCID: PMC42847.


Barami, K., Lemmon, V., Goldman, S. N-cadherin and Ng-CAM/8D9 are involved serially in the migration of newly generated Neurons into the adult songbird brain. Neuron 13: 567-582, 1994. PMID: 7522481.

Kirschenbaum, B., Nedergaard, M., Preuss, A., Barami, K., Fraser, R., Goldman, S. In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain. Cerebral Cortex 4: 576-589, 1994. PMID: 7703685.


Nedergaard, M., Goldman, S. Carrier mediated transport of lactic acid in cultured neurons and astrocytes. Am. J. Physiol. 265: R282-289, 1993. PMID: 8368382.

Goldman, S., Lemmon, V, Chin, S. Migration of newly generated neurons upon ependymally derived radial guide cells in explant cultures of the adult songbird forebrain. Glia 8:150-160, 1993 (cover photo). PMID: 8225557.


Goldman, S., Nedergaard, M. Newly generated neurons of the adult songbird brain become functionally active in long-term culture. Dev. Brain Res. 68:217-223, 1992. PMID: 1394968.

Goldman, S., Zaremba, A., Niedzwiecki, D. In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain. J. Neuroscience 12: 2532-2541, 1992. PMID: 1613545.


Nedergaard, M., Goldman, S., Desai, S., Pulsinelli, W. Acid-induced death in neurons and glia. J. Neuroscience 11:2489-2497, 1991. PMID: 1869926.


Goldman, S. Neuronal development and migration in explant cultures of the adult canary forebrain. J. Neuroscience 10: 2931-2939, 1990. PMID: 2204684.


Goldman, S., Pulsinelli, W., Clarke, W., Kraig, R., Plum, F. The effects of extracellular acidosis on neurons and glia in vitro. J. Cereb. Blood Flow Metab. 9: 471-477, 1989. PMID: 2738113.


Goldman, S., Gandy, S. Squamous carcinoma as a late complication of intra-cerebroventricular epidermoid. J. Neurosurg. 66:618-620, 1987.


Goldman, S., Monahan, J., Schneider, B. The regional and subcellular development of cholecystokinin immuno-reactivity in vertebrate brain. Dev. Brain Res. 22:237-246, 1985. PMID: 4052814.


Goldman, S., Nottebohm, F. Neuronal production, migration and differentiation in a vocal control nucleus of the adult female canary brain. Proc. Natl. Acad. Sci. 80:2390-2394, 1983. PMID: 6572982.


Lorenz, D., Goldman, S. Vagal mediation of the cholecystokinin satiety effect in rats. Physiol. Behav. 29:599-604, 1982. PMID: 6294698.